A chronic wound model to investigate skin cellular senescence

Abstract

Wound healing is an essential physiological process for restoring normal skin structure and function post-injury. The role of cellular senescence, an essentially irreversible cell cycle state in response to damaging stimuli, has emerged as a critical mechanism in wound remodeling. Transiently-induced senescence during tissue remodeling has been shown to be beneficial in the acute wound healing phase. In contrast, persistent senescence, as observed in chronic wounds, contributes to delayed closure. Herein we describe a chronic wound murine model and its cellular senescence profile, including the senescence-associated secretory phenotype.

Senescent Cells: A Therapeutic Target in Cardiovascular Diseases

“…Several dozen new senolytic agents have been discovered and are currently being tested extensively. When targeting senescent cells in vivo, it is important to recognize that cellular senescence is a mechanism that prevents tumorigenesis and is important during embryogenesis, possibly wound healing (although removing senescent cells appears to enhance healing of chronic wounds [302,303], and host immunity. The distinction between physiological, beneficial senescence and pathological senescence is crucial, especially the impact of persistent senescent cells that have evaded removal by the immune system.…”