A Circulating Anticoagulant Against Factor

Acquired FV inhibitors: a needless iatrogenic complication of bovine thrombin exposure

“…Many of the early reported cases of FV inhibitors developed spontaneously in patients without any clearly identifiable cause. Common clinical events that preceded inhibitor development in these patients included surgical procedures, infections, or exposure to antibiotics (in particular, aminoglycosides) or blood transfusions 4‐23 . Other conditions associated with inhibitors included pre‐existing autoimmune diseases, malignancies, and pregnancy 14,18,19,24‐41 .…”