A clash of quorum sensing vs quorum sensing inhibitors: an overview and risk of resistance

Patel, R. B.; Soni, Mansi; Soyantar, Bilv; Shivangi, Suruchi; Sutariya, Swati; Saraf, Meenu; Goswami, Dweipayan

doi:10.1007/s00203-023-03442-x

Cited by 14 publications

(8 citation statements)

References 206 publications

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“…Bacterial biofilm formation increases their tolerance to stress and antibiotics [ 25 ]. The presence of biofilms enhances the virulence, pathogenicity, and even life-threatening nature of infections, especially in patients who are immunocompromised [ 26 ]. Inhibition of quorum sensing (sometimes termed “quorum quenching”) is an actively emerging strategy to prevent biofilm growth in Pseudomonas aeruginosa or Staphylococcus aureus infections [ 23 , 24 , 27 ].…”

Section: Bacterial Quorum Sensingmentioning

confidence: 99%

Interkingdom Detection of Bacterial Quorum-Sensing Molecules by Mammalian Taste Receptors

Kouakou

Lee

2023

Microorganisms

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Bitter and sweet taste G protein-coupled receptors (known as T2Rs and T1Rs, respectively) were originally identified in type II taste cells on the tongue, where they signal perception of bitter and sweet tastes, respectively. Over the past ~15 years, taste receptors have been identified in cells all over the body, demonstrating a more general chemosensory role beyond taste. Bitter and sweet taste receptors regulate gut epithelial function, pancreatic β cell secretion, thyroid hormone secretion, adipocyte function, and many other processes. Emerging data from a variety of tissues suggest that taste receptors are also used by mammalian cells to “eavesdrop” on bacterial communications. These receptors are activated by several quorum-sensing molecules, including acyl-homoserine lactones and quinolones from Gram-negative bacteria such as Pseudomonas aeruginosa, competence stimulating peptides from Streptococcus mutans, and D-amino acids from Staphylococcus aureus. Taste receptors are an arm of immune surveillance similar to Toll-like receptors and other pattern recognition receptors. Because they are activated by quorum-sensing molecules, taste receptors report information about microbial population density based on the chemical composition of the extracellular environment. This review summarizes current knowledge of bacterial activation of taste receptors and identifies important questions remaining in this field.

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Section: Bacterial Quorum Sensingmentioning

confidence: 99%

Interkingdom Detection of Bacterial Quorum-Sensing Molecules by Mammalian Taste Receptors

Kouakou

Lee

2023

Microorganisms

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“…With ethyl acetate and hexane serving as the eluent, the obtained crude material was purified by column chromatography on silica (60-120 mess) to produce (3 a-j). [34] 2-Amino thiazole (3.0 mmol, 1.0 equiv), DMAP (3.3 mmol, 1.1 equiv), corresponding acid (3.0 mmol, 1.0 equiv), and EDC.HCl (3.3 mmol, 1.1 equiv) were added to dichloromethane (20 mL) and stirred at room temperature for an entire night. TLC was used to observe the reaction.…”

Section: General Experimental Procedures For the Synthesis Of N-(benz...mentioning

confidence: 99%

“…Several publications described synthetic quorum sensing inhibitors. [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] Our research group is also involved in developing new quorum sensing inhibitors. [37] Most quorum sensing inhibitors that were developed either lost their effectiveness or become resistant to pathogenicity.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, in Silico Study and Biological Evaluation of N‐(Benzothiazol/Thiazol‐2‐yl)benzamide Derivatives as Quorum Sensing Inhibitors against Pseudomonas aeruginosa

Sharma,

Srivastava,

Kaushal

et al. 2023

Chemistry & Biodiversity

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The development of bacterial resistance to chemical therapy poses a severe danger to efficacy of treating bacterial infections. One of the key factors for resistance to antimicrobial medications is growth of bacteria in biofilm. Quorum sensing (QS) inhibition was created as an alternative treatment by developing novel anti‐biofilm medicines. Cell‐cell communication is impeded by QS inhibition, which targets QS signaling pathway. The goal of this work is to develop newer drugs that are effective against Pseudomonas aeruginosa by decreasing QS and acting as anti‐biofilm agents. In this investigation, N‐(benzo[d]thiazol‐2‐yl)benzamide/N‐(thiazol‐2‐yl)benzamide derivatives 3a‐h were designed and synthesized in good yields. Further, molecular docking analyses revealed that binding affinity values were founded ‐11.2 to ‐7.6 kcal/mol that were moderate to good. The physicochemical properties of these prepared compounds were investigated through in‐silico method. Molecular dynamic simulation was also used to know better understanding of stability of the protein and ligand complex. Comparing N‐(benzo[d]thiazol‐2‐yl)benzamide 3a to salicylic acid (4.40 ± 0.10) that was utilised as standard for quorum sensing inhibitor, the anti‐QS action was found greater for N‐(benzo[d]thiazol‐2‐yl)benzamide 3a (4.67± 0.45) than salicylic acid (4.40 ± 0.10). Overall, research results suggested that N‐(benzo[d]thiazol‐2‐yl)benzamide/N‐(thiazol‐2‐yl)benzamide derivatives 3a‐h may hold to develop new quorum sensing inhibitors.

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“…As a cellular communication mechanism, quorum sensing (QS) is considered an appealing target for combating bacterial infections because it regulates different critical biological processes of microorganisms, including biofilm formation, bioluminescence, antibiotic resistance, sporulation, and virulence factors. − Inhibition of the QS system has been shown to enhance antibiotic susceptibility in Staphylococcus aureus Therefore, although QS inhibitors do not have antibacterial activity, they have the potential to become antibiotic adjuvants, which is a complementary strategy for protecting existing drugs. − …”

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confidence: 99%

Dronedarone Enhances the Antibacterial Activity of Polymyxin B and Inhibits the Quorum Sensing System by Interacting with LuxS

Cui,

Zhang,

Liu

et al. 2024

ACS Infect. Dis.

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Quorum sensing (QS) is considered an appealing target for interference with bacterial infections. β-Adrenergic blockers are promising anti-QS agents but do not have antibacterial activity. We assessed the potential ability of adrenergic receptor inhibitors to enhance the antibacterial activity of polymyxin B (PB) against Klebsiella pneumoniae and determined that dronedarone has the most potent activity both in vitro and in vivo. We found that dronedarone increases the thermal stability of LuxS, decreases the production of AI-2, and affects the biofilm formation of K. pneumoniae. We also identified the direct binding of dronedarone to LuxS. However, the mechanism by which dronedarone enhances the antibacterial activity of PB has not been elucidated and is worthy of further exploration. Our study provides a basis for the future development of drug combination regimens.

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A clash of quorum sensing vs quorum sensing inhibitors: an overview and risk of resistance

Cited by 14 publications

References 206 publications

Interkingdom Detection of Bacterial Quorum-Sensing Molecules by Mammalian Taste Receptors

Interkingdom Detection of Bacterial Quorum-Sensing Molecules by Mammalian Taste Receptors

Synthesis, in Silico Study and Biological Evaluation of N‐(Benzothiazol/Thiazol‐2‐yl)benzamide Derivatives as Quorum Sensing Inhibitors against Pseudomonas aeruginosa

Dronedarone Enhances the Antibacterial Activity of Polymyxin B and Inhibits the Quorum Sensing System by Interacting with LuxS

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