Investment decision is a traditional multi-attribute decision making (MADM) problem since it has many uncertainty factors and incomplete information such as investment value, cost, sales, etc. D numbers theory is a useful tool to deal with uncertainty factors and incomplete information. In this paper, interval number and D numbers theory are revealed in the uncertain factor and incomplete information of investment decision. The weights of uncertain factors are calculated using entropy weight method. Thus, a new MADM model for investment decision based on D numbers theory is proposed. Numerical example is used to illustrate the efficiency of the proposed method.