A Classification of Chronic Hepatitis

Groote, J. De; Desmet, V J; Gedigk, P.; Korb, G; Popper, H; Poulsen, Hemming; Scheuer, Peter J.; Schmid, Martin; Thaler, H; Uehlinger, E; Wepler, W

doi:10.1016/s0140-6736(68)90710-1

Cited by 778 publications

(165 citation statements)

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“…The first histological classification was published in 1968 [9], which was essentially a qualitative classification of liver biopsy. The authors coined the terminology ''chronic persistent and chronic aggressive hepatitis.''…”

Section: Consensus Statementsmentioning

confidence: 99%

Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL)

et al. 2008

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Section: Consensus Statementsmentioning

confidence: 99%

Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL)

et al. 2008

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“…However, in the trial and research setting, evaluation of biopsies is carried out using semiquantitative scoring systems that produce shorthand values for various categories of inflammation (grade) and fibrosis and architectural disruption (stage). The Ishak or ''revised Knodell'' system attempts to correct the criticism of numerical discontinuity by reintroducing the number 2 [52][53][54]. In other words, the Knodell system classified fibrosis into stages 0, ''no fibrosis;'' 1, ''portal fibrosis;'' 3, ''bridging fibrosis;'' 4 ''cirrhosis'' with the absence of stage 2, which describes ''portal fibrosis with septae outside the portal area.''…”

Section: Morphological Evaluation Of Liver Fibrosis: Current Methods mentioning

confidence: 99%

Asian-Pacific Association for the Study of the Liver (APASL) consensus guidelines on invasive and non-invasive assessment of hepatic fibrosis: a 2016 update

et al. 2016

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“…In Zürich, we concocted what became the standardized classification for the next 30 years 36 and went straight to the World Congress of Gastroenterology in Prague, Czechoslovakia, to present the new classification, and to the subsequent meeting of the International Association for the Study of the Liver (IASL) in Karlovy Vary. This was where Sheila Sherlock, then president of IASL, baptized our group "the Gnomes of Zürich", whom she claimed to be as influential in hepatological semantics as the real Gnomes of Zü-rich (the bankers) are in the world's financial affairs.…”

Section: Chronic Hepatitismentioning

confidence: 99%

The amazing universe of hepatic microstructure†

Desmet

2009

Hepatology

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An informal review is presented by the author of his 50 years of involvement in practice and research in hepatopathology. Some background for the author's attitude and meandering pathway into his professional career serves as introduction to a short discussion of the main topics of his interest and expertise. Histogenesis of liver cancer was the theme of early work for a Ph.D. thesis, the results of which were lost into oblivion due to local rules and circumstances, but were rescued three decades later. His conclusions about the cells of origin of liver cancer remain concordant with the newer concepts in the field after nearly half a century. Studies in the field of chronic hepatitis became a long saga, involving the first classification of this syndrome by "the Gnomes" in 1968, histochemical investigations of viral antigens, lymphocyte subsets and adhesion molecules, and a quarter century later, the creation of a new classification presently in use. Cholestasis was a broadening field in diagnostic entities and involved the study of liver lesions, comprising pathways of bile regurgitation (including reversed secretory polarity of hepatocytes) and so-called ductular reaction. The latter topic has a high importance for the various roles it plays in modulating liver tissue of chronic cholestasis into biliary cirrhosis, and as the territory of hepatic progenitor cells, crucial for liver regeneration in adverse conditions and in development of liver cancer. Study of the embryology of intrahepatic bile ducts helped to clarify the strange appearance of the ducts in "ductal plate configuration" in several conditions, including some forms of biliary atresia with poor prognosis and all varieties of fibrocystic bile duct diseases with "ductal plate malformation" as the basic morphologic lesion. (HEPATOLOGY 2009;50: 333-344.)

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A Classification of Chronic Hepatitis

Cited by 778 publications

References 0 publications

Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL)

Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL)

Asian-Pacific Association for the Study of the Liver (APASL) consensus guidelines on invasive and non-invasive assessment of hepatic fibrosis: a 2016 update

The amazing universe of hepatic microstructure†

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