Safety analyses in the automotive domain (in particular automated driving) present unprecedented challenges due to its complexity and tight integration with the physical environment. Given the diversity in the types of cars, potentially unlimited number of possible environmental and driving conditions, it is crucial to devise a systematic way of managing variability in hazards, driving and environmental conditions in individual cars, families of cars, and families of families of cars to facilitate analyses efficiently. To this end, we present our ongoing work in a research project that focuses on devising a model-based reasoning framework for systematically managing hazards in the automotive domain and supporting safety analyses (e.g., falsification). CCS CONCEPTS • Computing methodologies → Model verification and validation; • Software and its engineering → Software product lines;