A Clean and Efficient Conversion of Aldehydes into the Corresponding Nitriles Using Ionic Supported Triphenylphosphine and CBr4

Two Ways of Preparing Benzonitriles Using BrCCl3–PPh3 as the Reagent

“…Recently, this reaction methodology has been augmented with the use of the 3-butyl-1,2-dimethyl-1H-imidazozoliundiphenyl phosphinebenzenesulfonate-CBr 4 reagent. 24 We found that the reagent system BrCCl 3 -PPh 3 -Et 3 N works well for the dehydration of benzaldoximes to benzonitriles (Table 3). While Appel et al 23 had used 1,2-dichloroethane and Kim et al 25 had reported on the use of acetonitrile for the system CCl 4 -PPh 3 , we again used CH 2 Cl 2 as solvent in the reactions, mostly because of the simplicity of the subsequent reaction work-up.…”