A clinical and computational study on anti-obesity effects of hydroxycitric acid

Tomar, Manu; Rao, Raghavendra Prahlad; Dorairaj, Palaniyamma; Koshta, Abhishek; Suresh, Sowbhagya; Rafiq, Mohamed; Kumawat, Rajesh Kumar; Paramesh, Rangesh; Babu, Uma S.; Venkatesh, Kareenhalli V.

doi:10.1039/c9ra01345h

Cited by 32 publications

(20 citation statements)

References 37 publications

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“…206 Importantly, several ACLY inhibitors including ETC-1002 (Phase 2/3 clinical trials) and hydroxycitrate (randomised control trials) have shown high efficacy in lowering low-density lipoprotein-cholesterol and good tolerability in patients with cardiovascular disease and type 2 diabetes (Table 1), thus indicating that ACLY inhibition could represent a well-tolerated therapeutic strategy. [207][208][209][210][211] There is considerable interest in ACLY as a target for anticancer drugs; however, clinical trial studies in this context are far more limited when compared with dyslipidaemia cases. Nevertheless, there is a plethora of preclinical evidence to support the integral role of ACLY in tumorigenesis and the potential clinical benefits for its selective inhibition.…”

Section: Therapeutically Exploiting Fatty Acid Metabolism In Cancermentioning

confidence: 99%

Reprogramming of fatty acid metabolism in cancer

2019

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A common feature of cancer cells is their ability to rewire their metabolism to sustain the production of ATP and macromolecules needed for cell growth, division and survival. In particular, the importance of altered fatty acid metabolism in cancer has received renewed interest as, aside their principal role as structural components of the membrane matrix, they are important secondary messengers, and can also serve as fuel sources for energy production. In this review, we will examine the mechanisms through which cancer cells rewire their fatty acid metabolism with a focus on four main areas of research. (1) The role of de novo synthesis and exogenous uptake in the cellular pool of fatty acids. (2) The mechanisms through which molecular heterogeneity and oncogenic signal transduction pathways, such as PI3K-AKT-mTOR signalling, regulate fatty acid metabolism. (3) The role of fatty acids as essential mediators of cancer progression and metastasis, through remodelling of the tumour microenvironment. (4) Therapeutic strategies and considerations for successfully targeting fatty acid metabolism in cancer. Further research focusing on the complex interplay between oncogenic signalling and dysregulated fatty acid metabolism holds great promise to uncover novel metabolic vulnerabilities and improve the efficacy of targeted therapies.

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Section: Therapeutically Exploiting Fatty Acid Metabolism In Cancermentioning

confidence: 99%

Reprogramming of fatty acid metabolism in cancer

2019

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“…The major organic acid in the fruit rind of Garcinia is hydroxycitric acid (HCA), a proven natural antiobese agent (Onakpoya et al, 2011). Tomar et al (2019) reported the anti-obesity effects of HCA with the help of clinical data and metabolic model analysis. They found that HCA treatment reduced body weight gain and fat accumulation in obese subjects.…”

Section: Introductionmentioning

confidence: 99%

Impact of different drying methods on nutritional quality of Garcinia cowa and Garcinia pedunculata fruits

Sagolsem¹,

Rathi²,

Baishya³

2021

JEB

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Aim: The present study was undertaken to establish a suitable drying process for Garcinia cowa and Garcinia pedunculata fruits for maximum retention of their nutritional qualities. Methodology: Slices of three different thickness with 0.3, 0.6, 0.9 cm of G. cowa and G. pedunculata fruits were dried by sun drying, solar drying and by cabinet drying at three different temperatures (50°C, 70°C and 90°C). Results: The mean crude fat and ash content were higher in G. cowa than G. pedunculata while later was found rich in crude protein and Fe contents. Total phenol content ranged between 881.31-888.65 and 719.00-736.74 mg gallic acid equivalent 100 g-1, total flavonoid content between 89.21-90.06 and 51.00-52.54 mg quercetin equivalent 100 g-1 and mean HCA contents ranged between 3.13-3.92% and 1.84-1.99% for G. cowa and G. pedunculata, respectively. The methanolic extracts exhibited significant antioxidant activity. With lower IC50 values, G. cowa had higher antioxidant activity than G. pedunculata. Interpretation: Oven drying at 50°C and 0.9 cm slice thickness for drying resulted in better retention of total phenolic and flavonoid contents with better antioxidant activities.

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“…Study results showed that there was significant reduction in the body weight, serum triglycerides, HDL, and LDL levels. The hydroxy citric acid treatment may reduce the body weight gain and fat deposits in obese patients [67]. The enzymatic activities and proteins levels of the citrate synthase were reduced in obese patients in another study of human omental adipose tissue [68].…”

Section: Role Of Citrate In Fatty Liver Diseasementioning

confidence: 97%

Role of Sodium dependent SLC13 transporter and its inhibitors in various metabolic disorders

Akhtar

Khan

Kumar

et al. 2022

Preprint

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The sodium dependent SLC13 family transporters comprise of the five genes SLC13A1, SLC13A2 (NaDC1), SLC13A3 (NaDC3), SLC13A4 and SLC13A5 (NaCT). Among them the three NaDC1, NaDC3 and NaCT are sodium dependent transporters such as di-carboxylates (succinate, malate, α-ketoglutarate) and tricarboxylates (citrate). The mouse and the human NaCT structures have still not been crystallized, the information to the structures is taken from the related bacterial transporter of VcINDY. Citrate in the cytosol works as precursor for the fatty acid synthesis, cholesterol, and low-density lipoproteins. The excess citrate from the matrix is translocated to the cytosol for fatty acid synthesis through these receptors and thus controls the energy balance by downregulating the glycolysis, tricarboxylic acid (TCA), and fatty acid breakdown. These transporters play an important role in regulating various metabolic diseases including cancer, diabetes, obesity, fatty liver diseases and CNS disorders. These di and tricarboxylate transporters are emerging as new targets for metabolic disorders such as obesity and diabetes. The mutation in the function of the NaCT causes several neurological diseases including neonatal epilepsy and impaired brain development whereas mutation of the citrate present in the liver may provide positive effect. Therefore, continued efforts from the earlier work on citrate transporter are required for the development of citrate inhibitors. In this review the structure, function, and regulation of the NaCT receptors are discussed. The review also highlights citrate role in diagnosing diseases such as cancer, diabetes, fatty liver, and diabetes. The therapeutic perspective of synthetic inhibitors against NaCT receptors are succinctly summarized.

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A clinical and computational study on anti-obesity effects of hydroxycitric acid

Abstract: Hydroxycitric acid (HCA), a major active ingredient of Garcinia cambogia extracts, is known to suppress body weight gain and fat synthesis in animals and humans.

Cited by 32 publications

References 37 publications

Reprogramming of fatty acid metabolism in cancer

Reprogramming of fatty acid metabolism in cancer

Impact of different drying methods on nutritional quality of Garcinia cowa and Garcinia pedunculata fruits

Role of Sodium dependent SLC13 transporter and its inhibitors in various metabolic disorders

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