A clinical and electrophysiologic survey of childhood guillain-barré syndrome

Hung, Po-Cheng; Chang, Wen-Neng; Huang, Laura; Huang, Song‐Chei; Chang, Ying-Chao; Chang, Chin-Jung; Chang, Chen-Sheng; Wang, Kuo-Wei; Cheng, Ben-Chung; Chang, Hsueh‐Wen; Lu, Cheng-Hsien

doi:10.1016/s0887-8994(03)00403-x

Cited by 44 publications

(61 citation statements)

References 33 publications

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“…This study is the first study in Upper Egypt. The occurrence of GBS in children increases with age and it is quite rare in children younger than 2 years-old [Hung et al 2004]; this is in agreement with our series as only one patient was under 2 years (1.5 years).…”

Section: Discussionsupporting

confidence: 92%

A comparison between plasmapheresis and intravenous immunoglobulin in children with Guillain–Barré syndrome in Upper Egypt

Saad

Mohamad

Elhamed

et al. 2015

Ther Adv Neurol Disord

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Objective: The aim of our study is to assess the clinico-electrophysiological profile of children with Guillain-Barré syndrome (GBS) in Upper Egypt and to compare the efficacy of plasmapheresis versus other treatment modalities. Patients and methods:This was a retrospective study of children from January 2010 to October 2014 diagnosed as GBS. It included 62 cases. Results: Acute inflammatory demyelinating polyradiculoneuropathy (AIDP) was the most prevalent type of GBS in our locality. As regards the treatment, 32 cases received plasmapheresis while 30 patients received intravenous immunoglobulin. We found a significant decrease in the duration of hospitalization and a significant increase in the number of children with complete recovery in cases treated with plasmapheresis. Conclusion: GBS is not uncommon in children of Upper Egypt, with AIDP the most prevalent type. Plasmapheresis is the best treatment modalities for GBS as it reduces the duration of hospital stay and hastens the recovery of those children.

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Section: Discussionsupporting

confidence: 92%

A comparison between plasmapheresis and intravenous immunoglobulin in children with Guillain–Barré syndrome in Upper Egypt

Saad

Mohamad

Elhamed

et al. 2015

Ther Adv Neurol Disord

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“…[7] Since the first report of GBS in childhood by Mannier-Vinard in 1925, showing an incidence of 0.24–1.26 per 100,000 children under 15 years of age,[9] the age-specific incidence was 1.26 in 100,000 in the 1–4 years age group and 0.24 in 100,000 in the 5–9 years age group. [12] GBS has a worldwide distribution and affects all races and all ages, including the newborn.…”

Section: Discussionmentioning

confidence: 99%

“…These are acute inflammatory demyelinating polyradiculoneuropathy (AIDP); axonal forms of GBS, which include acute motor-sensory axonal neuropathy (AMSAN) and acute motor axonal neuropathy (AMAN); and Miller Fisher syndrome (MFS). [78]…”

Section: Introductionmentioning

confidence: 99%

Clinical features and prognosis with Guillain-Barré syndrome

Akbayram

Doğan

Akgün

et al. 2011

Ann Indian Acad Neurol

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Background:Guillain-Barré syndrome (GBS) is an acute inflammatory polyneuropathy commonly characterized by rapidly progressive, symmetric weakness and areflexia.Materials and Methods:We retrospectively assessed the clinical manifestations, results of electrodiagnostic tests, functional status and prognosis of 36 children diagnosed with GBS.Results:Based on clinical and electrophysiological findings, the patients were classified as having acute inflammatory demyelinating polyradiculoneuropathy (AIDP) (n = 25), acute motor axonal neuropathy (AMAN) (n = 10) and acute motor-sensory axonal neuropathy (AMSAN) (n = 1). Twenty (55.5%) patients were males and 16 (44.5%) patients were females. The mean age of the 36 patients was 68.1 ± 45.01 months (range, 6–180 months). Five (13.8%) patients were younger than 2 years. The most common initial symptoms were limb weakness, which was documented in 34 (94.4%) patients. In our study, 18 patients (51.4%) showed albuminocytological dissociation (raised protein concentration without pleocytosis) on cerebrospinal fluid (CSF) examination. Three patients (8.3%) required mechanical ventilation therapy during hospitalization. Unfortunately, three (8.3%) patients died; one patient had AIDP and two patients had axonal involvement (one case was AMAN and another case was AMSAN). When we compared the cases of residual sequel/dead and cases of complete recovery for neural involvement type including AIDP, AMAN and AMSAN, we did not find a statistically significant difference between the groups (P > 0.05).Conclusion:Our findings showed that cases of GBS was not uncommon in children younger than 2 years of age, and CSF protein level might be found high in the first week of the disease in about one half of the patients, with a higher rate of morbidity and mortality in patients with axonal involvement than in those with AIDP.

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“…18 Proximal muscle weakness was more prominent than distal. At the height of the disease the majority of the patient were bed ridden and many of them had quadriparesis.…”

Section: Resultsmentioning

confidence: 99%