A clinical and radiographic evaluation of the efficacy of nanohydroxyapatite (Sybograf^™) versus bioactive calcium phosphosilicate putty (Novabone^®) in the treatment of human periodontal infrabony defects: A randomized clinical trial

Comparing Nanohydroxyapatite Graft and Other Bone Grafts in the Repair of Periodontal Infrabony Lesions: A Systematic Review and Meta-Analysis

“…RCTs were used in all of the included investigations. Except for one study, which used a parallel study design [ 52 ], each experiment used a split-mouth design. Five out of seven studies used synthetic BGs [ 52 , 53 , 54 , 55 , 56 ], whereas one study used autogenous BG [ 57 ] and another study used xenogenic graft [ 58 ].…”

“…Except for one study, which used a parallel study design [ 52 ], each experiment used a split-mouth design. Five out of seven studies used synthetic BGs [ 52 , 53 , 54 , 55 , 56 ], whereas one study used autogenous BG [ 57 ] and another study used xenogenic graft [ 58 ]. The maximum follow-up time varied among the included trials, ranging from 6 months in five trials to 9 and 12 months in the other two, respectively [ 52 ].…”

“…Five out of seven studies used synthetic BGs [ 52 , 53 , 54 , 55 , 56 ], whereas one study used autogenous BG [ 57 ] and another study used xenogenic graft [ 58 ]. The maximum follow-up time varied among the included trials, ranging from 6 months in five trials to 9 and 12 months in the other two, respectively [ 52 ]. Four studies reported using post-operative antibiotics [ 52 , 55 , 57 , 58 ], whereas three studies did not disclose the use of post-operative antibiotics [ 53 , 54 , 56 ].…”

“…The maximum follow-up time varied among the included trials, ranging from 6 months in five trials to 9 and 12 months in the other two, respectively [ 52 ]. Four studies reported using post-operative antibiotics [ 52 , 55 , 57 , 58 ], whereas three studies did not disclose the use of post-operative antibiotics [ 53 , 54 , 56 ].…”

“…Similarly, smokers’ reaction to periodontal therapy is less advantageous than non-smokers’ [ 70 ], and smokers have lower CAL gains for regeneration treatment as compared to non-smokers. The majority of the research followed comparable post-operative procedures; however, antibiotics were prescribed in four trials [ 52 , 55 , 57 , 58 ], and three studies gave no data on any specific post-operative measures [ 53 , 54 , 56 ]. The benefits of post-operative antibiotics have not been evaluated because the bulk of research utilised post-operative antibiotics.…”