A clinical and serologic study of 103 children with measles vaccine failure

Cherry, James D.; Feigin, Ralph D.; Shackelford, Penelope G.; Hinthorn, Daniel R.; Schmidt, Rose Rita

doi:10.1016/s0022-3476(73)80070-8

Cited by 79 publications

(25 citation statements)

References 18 publications

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“…In addition, CF antibody titers, rarely present in early measles (personal observation), were detected in over 70% of the acute-phase specimens and were markedly higher in the convalescent-phase specimens of those cases classified as secondary responders. Moreover, illness was milder among secondary responders, consistent with previous reports [Cherry et al, 1973;Krause et al, 1979;Smith et al, 1982;Welliver et al, 19771. These data suggest that IgM detection can be a useful diagnostic tool in measles outbreaks, even where the majority of cases occur in previously vaccinated persons. It remains unclear, however, why IgM antibodies are detected after natural measles infection but not secondary measles vaccination.…”

Section: Discussionsupporting

confidence: 91%

Immunoglobulin M antibody response to measles virus following primary and secondary vaccination and natural virus infection

Erdman

Heath

Watson

et al. 1993

Journal of Medical Virology

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The use of IgM antibody detection for the classification of the primary and secondary measles antibody response in persons following primary and secondary vaccination and natural measles virus infection was examined. Of 32 nonimmune children receiving primary measles vaccination, 31 (97%) developed IgM antibodies, consistent with a primary antibody response. Of 21 previously vaccinated children with low levels of preexisting IgG antibodies who responded to revaccination, none developed detectable IgM antibodies, whereas 33 of 35 (94%) with no detectable preexisting IgG antibodies developed an IgM response. Of a sample of 57 measles cases with a prior history of vaccination, 55 (96%) had detectable IgM antibodies. Of these, 30 (55%) were classified as having a primary antibody response and 25 (45%) a secondary antibody response based on differences in their ratios of IgM to IgG antibodies. Differences in the severity of clinical symptoms between these 2 groups were consistent with this classification scheme. These findings suggest that 1) an IgM response follows primary measles vaccination in the immunologically naive, 2) an IgM response is absent on revaccination of those previously immunized, and 3) an IgM response may follow clinical measles virus infection independent of prior immunization status.

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Section: Discussionsupporting

confidence: 91%

Immunoglobulin M antibody response to measles virus following primary and secondary vaccination and natural virus infection

Erdman

Heath

Watson

et al. 1993

Journal of Medical Virology

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“…The single patient who was vaccinated when older than fifteen months and who had no IgM antibody response had been immunized since the age of 4 years and 10 months. This probably represents a secondary vaccine failure [7,8]. Our study therefore shows that the main cause of vaccine failure is primary failure due to persistent maternal antibodies and cold chain defect.…”

Section: Discussionmentioning

confidence: 60%

“…In secondary vaccine failure, clinically apparent infection develops despite an immune response to vaccination [7][8][9]. However, this elicited response may not be adequate to protect against the subsequent inoculum of wild-type virus, or an initially protective response may wane over time.…”

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confidence: 99%

Measles Vaccine Failure

Abanamy¹,

Khalil²,

Salman³

et al. 1991

Ann Saudi Med

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“…Adaptation of 3 out of the 5 strains of attenuated measles virus to HDC has apparently increased the immunogenicity of these viruses because a fourfold increase in HI antibody was noted in most of the reimmunized children 1 month after revaccination at which time the decrease in titre was nil or negligible. Since the rates of seroconversion and protection induced by the usual attenuated virus vaccines was found to be insufficient (Linnemann et al 1972;Cherry et al 1972Cherry et al . 1973, the idea of revaccinating children with attenuated vaccines was suggested by Immunization Practices Advisory Committee of the United States of America in 1977(CDC, 1977.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of live attenuated measles vaccines prepared in human diploid cells for reimmunization

et al. 1988

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SUMMARYTwo live attenuated measles vaccines developed in baby calf kidney cells, a similar vaccine produced in chick embryo chorioallantoic cells and five vaccines prepared from human diploid cells (HDC) have been studied by subcutaneous injection in groups of susceptible and immune children in three field trials. The results indicated that the vaccine developed in chick embryo cells which caused mild clinical reactions, had induced a lower seroprotection rate in susceptible children and only a low rise in hemagglutination-inhibition (HI) antibody titre in previously immunized children. The serological responses induced by vaccines developed in HDC or in calf kidney cells were satisfactory in both susceptible and immune children. The superiority of HDC grown measles vaccine for revaccination is discussed.

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A clinical and serologic study of 103 children with measles vaccine failure

Cited by 79 publications

References 18 publications

Immunoglobulin M antibody response to measles virus following primary and secondary vaccination and natural virus infection

Immunoglobulin M antibody response to measles virus following primary and secondary vaccination and natural virus infection

Measles Vaccine Failure

Evaluation of live attenuated measles vaccines prepared in human diploid cells for reimmunization

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