A clinical appraisal of the plasma concentration and endogenous clearance of creatinine

Doolan, Paul D.; Alpen, Edward L.; Theil, Gerit

doi:10.1016/0002-9343(62)90183-3

Cited by 356 publications

(152 citation statements)

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“…This can be explained by the fact that CCL cr exceeds the true GFR by 19% because of tubular secretion. 5 In their study, Froissart et al showed that there was a very good global agreement between measured GFR and both eGFR MDRD and eGFR mC-G . On average, eGFR MDRD was only 1.0 ml/ min per 1.73 m² less than measured GFR; eGFR mC-G was only 1.9 ml/min per 1.73 m² greater than measured GFR.…”

Section: Discussionmentioning

confidence: 93%

“…8 Moreover, CL cr overestimates the GFR due to tubular creatinine secretion. 5 To compensate for these previous limitations, investigators have devised equations that predict GFR based on SCr, gender, body size, race and age. The most widely used equations are the C-G equation, which produces GFR values in ml/min, and the MDRD equation, which produces GFR values in ml/min per 1.73 m².…”

Section: Discussionmentioning

confidence: 99%

“…4 If the effect of secretion is ignored, then all of the filtered creatinine will be excreted and this will reflect the GFR. Thus the GFR and CL cr will be equal: [UCr x V]/SCr, 5 where UCr is urine creatinine, V is the 24-hour urine volume and SCr is the serum creatinine. However, CL cr tends to exceed the true GFR due to tubular secretion.…”

mentioning

confidence: 99%

“…5 It should therefore be adjusted to body surface area (BSA) so as to obtain the corrected creatinine clearance (CCL cr ) in ml/min/1.73 m² by the following equation: 6 The normal value of CCL cr is 95 ± 20 ml/min per 1.73 m² in women and 120 ± 25 ml/min per 1.73 m 2 in men. 5 SCr varies inversely with GFR and is used to assess stable kidney function, as a rise in SCr represents a reduction in GFR. However, in acute renal failure, GFR is markedly reduced and there is no time for creatinine to accumulate.…”

mentioning

confidence: 99%

“…The CL cr was calculated by the following equation: 5 The CL cr was then adjusted to BSA to get CCL cr in ml/min per 1.73 m² by the following formula, where BSA equals the square root ([height in cm x weight in Kg]/3600): 8,16 Depending on a patient's gender, age and SCr, C-G was used to obtain the predicted CL cr , which was abbreviated as eGFR C-G , as in the following formula: 10 The eGFR C-G (ml/min) was adjusted to BSA (modified C-G) to obtain eGFR mC-G (ml/min per 1.73 m²): eGFR mC-G = eGFR C-G x 1.73/BSA.…”

mentioning

confidence: 99%

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Assessment of Glomerular Filtration Rates by Cockcroft-Gault and Modification of Diet in Renal Disease Equations in a Cohort of Omani Patients

Al-Osali¹,

Al-Qassabi²,

Al-Harthi³

2014

SQUMJ

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abstract:Objectives: Glomerular filtration rate (GFR) is the best index of renal function and is frequently assessed by corrected creatinine clearance (CCL cr ). The limitations of CCL cr have inspired researchers to derive easy formulas to estimate GFR, with Cockcroft-Gault (C-G) and the modification of diet in renal disease (MDRD) being the most widely used. This study aimed to evaluate the validity of these equations by finding the relation between CCL cr and estimated GFR (eGFR) by C-G, modified C-G and MDRD equations. Methods: From 2007 to 2011, 158 subjects were analysed for serum creatinine and CCL cr at Bowsher Polyclinic, Muscat, Oman. The C-G equation was used to obtain eGFR C-G which was adjusted to body surface area (BSA) to obtain eGFR mC-G , and the MDRD equation was used to obtain eGFR MDRD . The eGFR MDRD , eGFR mC-G and eGFR C-G were then compared to CCL cr . Results: The eGFR MDRD , eGFR mC-G and eGFR C-G significantly correlated with CCL cr , with a slightly stronger correlation with eGFR MDRD (r = 0.701, 0.658 and 0.605, respectively). A receiver operating characteristic curve analysis showed that the diagnostic accuracy of eGFR MDRD for diagnosing chronic kidney disease (CKD) was higher than that of eGFR mC-G , which in turn was higher than that of eGFR C-G (area under the curve was 0.846, 0.831, and 0.791; cut-off limits were 61.9, 58.3 and 59.5, respectively). Conclusion: C-G and MDRD equations can be an alternative to the CCL cr test for assessing GFR, thus avoiding the need for the cumbersome and expensive GFR test. The MDRD formula had greater validity than the C-G equation and the C-G equation validity was improved by an adjustment to BSA.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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