A clinical bulbar assessment scale (<scp>CBAS</scp>) for amyotrophic lateral sclerosis

Ball, Laura J.; Geske, Jenenne; Burton, Elizabeth; Pattee, Gary L.

doi:10.1002/mus.27738

Cited by 3 publications

(1 citation statement)

References 118 publications

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“…Thus, CNS-BFS has been recommended for use in evaluating bulbar dysfunction [ 11 ]. In addition, the CNS-BFS can be applied as an important verification tool in the development of other objective, quantitative evaluation tools, such as the clinical bulbar assessment scale (CBAS) [ 12 ] and the amyotrophic lateral sclerosis-Bulbar dysfunction index (ALS-BDI) [ 13 ]. Like in the CNS-BFSC, the CNS-BFS C also exhibited good sensitivity in our study.…”

Section: Discussionmentioning

confidence: 99%

Validation of the Center for Neurologic Study Bulbar Function Scale–Chinese version in a population with amyotrophic lateral sclerosis

Ye,

Chen,

Murphy

et al. 2024

Orphanet J Rare Dis

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Objective The Center for Neurologic Study Bulbar Function Scale (CNS-BFS) was specifically designed as a self-reported measure of bulbar function. The purpose of this research was to validate the Chinese translation of the CNS-BFSC as an effective measurement for the Chinese population with ALS. Methods A total of 111 ALS patients were included in this study. The CNS-BFSC score, three bulbar function items from the ALSFRS-R, and visual analog scale (VAS) score for speech, swallowing and salivation were assessed in the present study. Forty-six ALS patients were retested on the same scale 5–10 days after the first evaluation. Results The CNS-BFSC sialorrhea, speech and swallowing subscores were separately correlated with the VAS subscores (p < 0.001). The CNS-BFSC total score and sialorrhea and speech scores were significantly correlated with the ALSFRS-R bulbar subscore (p < 0.001). The CNS-BFSC total score and ALSFRS-R bulbar subscale score were highly predictive of a clinician diagnosis of impaired bulbar function (area under the receiver operating characteristic curve, 0.947 and 0.911, respectively; p < 0.001). A cutoff value for the CNS-BFSC total score was selected by maximizing Youden’s index; this cutoff score was 33, with 86.4% sensitivity and 93.3% specificity. The CNS-BFSC total score and the sialorrhea, speech and swallowing subscores had good–retest reliability (p > 0.05). The Cronbach’s α of the CNS-BFSC was 0.972. Conclusion The Chinese version of the CNS-BFSC has acceptable efficacy and reliability for the assessment of bulbar dysfunction in ALS patients.

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Section: Discussionmentioning

confidence: 99%

Validation of the Center for Neurologic Study Bulbar Function Scale–Chinese version in a population with amyotrophic lateral sclerosis

Ye,

Chen,

Murphy

et al. 2024

Orphanet J Rare Dis

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Amyotrophic Lateral Sclerosis–Bulbar Dysfunction Index–Remote: Test–Retest and Interrater Reliability of Candidate Items

Bouvier,

Green,

Tapia

et al. 2023

Am J Speech Lang Pathol

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Purpose: The primary aim of this study was to establish the reliability of candidate items as a step in the development of the Amyotrophic Lateral Sclerosis–Bulbar Dysfunction Index–Remote (ALS-BDI-Remote), a novel tool being developed for the detection and monitoring of bulbar signs and symptoms in remote settings. Method: The set of candidate items included 40 items covering three domains: cranial nerve examination, auditory-perceptual evaluation, and functional assessment. Forty-eight participants diagnosed with ALS and exhibiting a range of bulbar disease severity were included. Data collection for each participant took place on Zoom over three sessions. During Session 1, the participants were instructed to adjust their Zoom settings and to optimize their recording environment (e.g., lighting, background noise). Their cognition and eating were screened to determine their ability to follow instructions and their eligibility to perform the swallowing and chewing tasks. During Session 2, two speech-language pathologists (SLPs) administered the tool consecutively to determine the items' interrater reliability. During Session 3, one of the SLPs readministered the tool within 2 weeks of Session 1 to assess test–retest reliability. The reliability of each item was estimated using weighted kappa and the percentage of agreement. To be considered reliable, the items had to reach a threshold of 0.5 weighted kappa or 80% percentage agreement (if skewed distribution of the scores) for both interrater and test–retest reliability. Results: In total, 33 of the 40 candidate items reached the reliability cutoff for both reliability analyses. All assessment domains included reliable items. Items requiring very good visualization of structures or movements were generally less reliable. Conclusions: This study resulted in the selection of reliable items to be included in the next version of the ALS-BDI-Remote, which will undergo psychometric evaluation (reliability, validity, and responsiveness analyses). Additionally, the results contributed to our understanding of the remote administration of SLP assessments for telehealth applications.

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Validation of the Center for Neurologic Study Bulbar Function Scale–Chinese Version in a Population with Amyotrophic Lateral Sclerosis

Ye,

Chen,

Murphy

et al. 2023

Preprint

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Objective The Center for Neurologic Study Bulbar Function Scale (CNS-BFS) was specifically designed as a self-report measure of bulbar function. The purpose of this research was to validate the Chinese translation of the CNS-BFSC as an effective measurement for the Chinese ALS population. Methods A total of 111 ALS patients were included in this study. The CNS-BFSC, the three bulbar function items from the ALSFRS-R, and visual analog scales (VASs) for speech, swallowing and salivation were assessed in the study. Forty-six ALS patients were retested with the same scales 5–10 days after the first evaluation. Results CNS-BFSC sialorrhea, speech and swallowing subscores were separately correlated with VAS subscores (p < 0.001). The CNS-BFSC total, sialorrhea and speech scores were significantly correlated with the ALSFRS-R bulbar subscore (p < 0.001). The CNS-BFSC total score and ALSFRS-R bulbar subscale were highly predictive of clinician diagnosis of impaired bulbar function (area under the receiver operating characteristic curve, 0.947 and 0.911, respectively; p < 0.001). A cutoff value for the CNS-BFSC total score was selected by maximizing Youden's index; this cutoff score was 33, with 86.4% sensitivity and 93.3% specificity. The CNS-BFSC total score and the sialorrhea, speech and swallowing subscores had good–retest reliability (p > 0.05). The Cronbach’s α of the CNS-BFSC was 0.972. Conclusion The Chinese version of the CNS-BFSC has acceptable efficiency and reliability for the assessment of bulbar dysfunction in ALS patients.

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A clinical bulbar assessment scale (CBAS) for amyotrophic lateral sclerosis

Cited by 3 publications

References 118 publications

Validation of the Center for Neurologic Study Bulbar Function Scale–Chinese version in a population with amyotrophic lateral sclerosis

Validation of the Center for Neurologic Study Bulbar Function Scale–Chinese version in a population with amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis–Bulbar Dysfunction Index–Remote: Test–Retest and Interrater Reliability of Candidate Items

Validation of the Center for Neurologic Study Bulbar Function Scale–Chinese Version in a Population with Amyotrophic Lateral Sclerosis

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