A Clinical Case of Unilateral Ovarian Dysgerminoma and Pyometra in a Bitch

Antonov, Anton; Fasulkov, Ivan; Simeonov, R.

doi:10.14432/j.macvetrev.2014.04.013

Cited by 5 publications

(11 citation statements)

References 16 publications

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“…Some patients presented cystic endometrium hyperplasia, pyometra and consistent oestrus. These signs are related with hormones over-production (Greenlee and Patnaik 1985;Jackson et al 1985;Rolim et al 2010;Novotny et al 2011;Antonov et al 2014). Our case study describes ovarian dysgerminoma associated metastasis in the spleen of a bitch.…”

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confidence: 64%

Splenic metastasis in a bitch affected by an ovarian dysgerminoma - a case report

et al. 2018

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Dysgerminomas are infrequent neoplasms resulting from undifferentiated germinal cells, mainly observed in the bitch. Our case describes for the first time a dysgerminoma related splenic metastasis in a bitch. A 14-year-old crossbred bitch was admitted at our facility with a 3-month history of irregular oestrous cycle, vulvar swelling, haemorrhagic vaginal discharge, lethargy and anorexia. Cytological examination showed the presence of superficial epithelial cells of the vaginal mucosa with a high degree of cornification. Vaginoscopy showed the typical pale and crenulated mucosal folds (oestrus). Haematological analysis indicated moderate anaemia and leukocytosis, and increased level of oestrogen. Ultrasound examination showed a mass located caudally to the kidney in the region of the right ovary. Abdominal and thoracic radiographs confirmed the findings and did not reveal metastases. Suspecting an ovarian tumour, we decided to perform a complete ovariohysterectomy. Once located, the right ovary presented an increased volume, irregular shape and reddish colour. Samples collected during the procedure were stained with haematoxylin and eosin and observed under optical microscope. The cells were characterized by a scant cytoplasm, a large vesicle type nucleus with coarsely granular chromatin and distinct cell borders. The neoplastic cells were remarkably similar to those of a testicular seminoma, allowing for the diagnosis of ovarian dysgerminoma. Two years after the ovariohysterectomy, the owner reported history of increased volume of the abdomen and lethargy. A second surgery was performed during which an irregular splenic mass was found. The morphological diagnosis was “splenic metastasis of dysgerminoma”. To the authors' knowledge, dysgerminoma related splenic metastasis was never described in the bitch before.

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Splenic metastasis in a bitch affected by an ovarian dysgerminoma - a case report

et al. 2018

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“…When ovarian neoplasia is suspected, measuring hormone levels could give useful information about the biologic nature of the tumor. At the moment reports of hormonal production by dysgerminomas are too few both in human and veterinary medicine (ANTONOV et al, 2014).…”

Section: Sollier and Caquiasmentioning

confidence: 99%

“…In the case of the ovarian dysgerminoma reported herein, diagnosis of ovarian tumor was reached based on the history of estrous cycles and ultrasonography, which is the technique of choice to detect ovarian cysts or tumors (DIEZ BRU et al, 1998). Also, ultrasound allows for the detection of uterine anomalies, ascites and lymphadenophaties (KLEIN, 2007;NOVOTNY et al;2011;ANTONOV et al 2014). When there is effusion, abdominocentesis and thoracocentesis should be performed (MCENTEE, 2002), and a cytological analysis requested.…”

Section: Sollier and Caquiasmentioning

confidence: 99%

“…Neoplastic cells in dysgerminomas are positive for vimentin, and alkaline phosphatase, and negative for CD3, CD79a, cytokeratin, alpha-fetoprotein, inhibin-a and S-100 (PARK et al, 2009). Ovariohysterectomy is the treatment of choice (ANTONOV et al, 2014). A careful examination of all serosal surfaces, including omentum and diaphragm, and the excision or biopsy of any other lesion suspected to be metastatic should be done to assess the patient risk (MCENTEE, 2002).…”

Section: Sollier and Caquiasmentioning

confidence: 99%

“…The prognosis for all tumors appears to be the same, in spite of the histopathologic results. The prognosis is good when the tumor is completely resected and poor when there is evidence of metastasis (NOVOTNY et al, 2011;ANTONOV et al, 2014).…”

Section: Sollier and Caquiasmentioning

confidence: 99%

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Canine ovarian dysgerminoma

Podestá

Caquias

2020

Cienc. Rural

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This research aimed to describe a clinical case of ovarian dysgerminoma in a bitch, by showing clinical, ultrasound, surgical and pathological findings. The research also sought to emphasize the importance of establishing an early and definitive diagnosis through histopathology, establishing appropriate protocols for each patient. Ovarian tumors have a low incidence in dogs and cats. Dysgerminomas are a type of ovarian germ cell tumor. They develop in dogs of variable age, that may present clinical signs of hormonal imbalance such as persistent estrus, or pyometra. Prognosis is good in animals that undergo surgery and show no evidence of metastasis. This article presents a clinical case of a 6-year-old English Bulldog with persistent estrus for 2 months, and slightly depressed mental state. Ultrasound revealed the presence of a mass on the left ovary and uterine content. Ovariohysterectomy was performed and the mass was submitted to histopathological exam, which diagnosed an ovarian dysgerminoma.RESUMO: Neste trabalho descrevem-se caso clínico, achados de ultrassom, cirúrgicos e patológicos de disgerminoma ovárico em cadela. Os tumores ováricos têm baixa incidência em cães e gatos. Nesta categoria estão os tumores das células germinativas, a partir das quais se desenvolvem os disgerminomas. Acomete cadelas de idades variáveis, que podem apresentar sinais clínicos indiciando alterações hormonais, como cio persistente, ou piometra. O prognóstico em animais tratados cirurgicamente, sem evidência de metástase, é bom. Esta pesquisa relata um caso clínico em cadela, raça Bulldog Inglês, de 6 anos de idade, com presença de cio persistente por dois meses. O ultrassom revelou a presença de massa ao nível do ovário esquerdo e escasso conteúdo uterino. Foi realizada ovariohisterectomia e a peça cirúrgica foi enviada para anatomia patológica, que diagnosticou disgerminoma ovarico. Após a resolução do caso, ressalta-se a importancia do diagnóstico clinico e histopatológico precoce para estabelecer protocolos de tratamento adequados. Palavras-chave: neoplasias ovaricas, disgerminoma, tumor canino. CLINIC AND SURGERY

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Bilateral Dysgerminoma in a Senile Bitch Associated With Nodular Lymphoid Hyperplasia in Spleen and Pyometra: a Case Report

COLUMBARA¹,

VICENTE²,

SILVA³

et al. 2022

Ars Vet

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Ovarian neoplasms affect a low percentage of female dogs, and these tumors are classified according to their cellular origin and are considered rare. Dysgerminoma is a tumor derived from undifferentiated primordial ovarian germinal epithelium cells. In the male, this neoplasm is diagnosed as seminoma. Thus, dysgerminoma is not linked to the production of ovarian hormones such as estrogen and progesterone, which play a fundamental role in the establishment of pyometra. At Araujo Veterinary Hospital (HVA), a 15-year-old female Pinscher was admitted with mucopurulent vaginal discharge, abdominal enlargement, anorexia, polydipsia, and prostration clinical signs indicative of pyometra, radiographic and ultrasound examinations were requested, as well as a blood collection for hemogram and serum biochemistry. Ultrasound examination revealed uterine enlargement and hypoechoic content, in addition to bilateral ovarian cysts, measuring 7 cm in the right ovary and 3 cm in the left. The blood count revealed normal values in the erythrogram and the leukogram showed monocytosis and lymphopenia, in addition to macroplatelets. Biochemical examination revealed increased GGT values of 10 U/L. Ovariohysterectomy was performed and, in the trans-surgical period, nodules in the spleen were observed. So, the ovaries and a fragment of the lymphoid organ, were fixed and sent to the histopathology laboratory after surgical resection. Histopathology revealed ovarian dysgerminoma and lymphoid nodular hyperplasia. Ten days after the surgical procedure, the dog returned to the HVA for clinical evaluation and suture removal. However, three days after the return, the patient presented a convulsive condition evolving to death.

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A Clinical Case of Unilateral Ovarian Dysgerminoma and Pyometra in a Bitch

Cited by 5 publications

References 16 publications

Splenic metastasis in a bitch affected by an ovarian dysgerminoma - a case report

Splenic metastasis in a bitch affected by an ovarian dysgerminoma - a case report

Canine ovarian dysgerminoma

Bilateral Dysgerminoma in a Senile Bitch Associated With Nodular Lymphoid Hyperplasia in Spleen and Pyometra: a Case Report

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