A Clinical Comparison of Remifentanil or Alfentanil in Propofol-Anesthetized Cats Undergoing Ovariohysterectomy

Padilha, Samanta T; Steagall, Paulo V.; Monteiro, Beatriz P.; Kahvegian, M; Ubukata, Rodrigo; Rodrigues, Edilberto O; Rosa, A. L.; Aguiar, Antonio J. A.

doi:10.1016/j.jfms.2011.07.002

Cited by 9 publications

(19 citation statements)

References 19 publications

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“…Its use in cats, as a total intravenous anaesthesia (TIVA), alone or associated with opioids, has been described by various investigators (Ilkiw and Pascoe 2003, Mendes and Selmi 2003, Padilha and others 2011, Boudreau and others 2012). In one study (Liehmann and others 2006), the authors reported propofol-based TIVA as being advantageous over isoflurane in injured cats by virtue of its greater haemodynamic stability (arterial blood pressure was better maintained).…”

Section: Introductionmentioning

confidence: 99%

Evaluation and optimisation of propofol pharmacokinetic parameters in cats for target‐controlled infusion

et al. 2016

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The aim of this study was to develop and evaluate a pharmacokinetic model-driven infusion of propofol in premedicated cats. In a first step, propofol (10 mg/kg) was administered intravenously over 60 seconds to induce anaesthesia for the elective neutering of seven healthy cats, premedicated intramuscularly with 0.3 mg/kg methadone, 0.01 mg/kg medetomidine and 2 mg/kg ketamine. Venous blood samples were collected over 240 minutes, and propofol concentrations were measured via a validated high-performance liquid chromatography assay. Selected pharmacokinetic parameters, determined by a three-compartment open linear model, were entered into a computer-controlled infusion pump (target-controlled infusion-1 (TCI-1)). In a second step, TCI-1 was used to induce and maintain general anaesthesia in nine cats undergoing neutering. Predicted and measured plasma concentrations of propofol were compared at specific time points. In a third step, the pharmacokinetic parameters were modified according to the results from the use of TCI-1 and were evaluated again in six cats. For this TCI-2 group, the median values of median performance error and median absolute performance error were -1.85 per cent and 29.67 per cent, respectively, indicating that it performed adequately. Neither hypotension nor respiratory depression was observed during TCI-1 and TCI-2. Mean anaesthesia time and time to extubation in the TCI-2 group were 73.90 (±20.29) and 8.04 (±5.46) minutes, respectively.

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Section: Introductionmentioning

confidence: 99%

Evaluation and optimisation of propofol pharmacokinetic parameters in cats for target‐controlled infusion

et al. 2016

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“…The prolonged recovery time was to be expected as dogs were given a propofol-opioid infusion for approximately an hour. Prolonged propofol infusions cause significantly delayed anaesthetic recoveries in cats (Padilha et al 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Each drug could partially attenuate the undesirable effects of the other (Ilkiw et al 2003). The safety and stability of this combination have been documented (Vuyk et al 1996;Mendes and Selmi 2003;Auckburally et al 2008;Padilha et al 2011). However, prior work largely evaluated the effect of continuous infusions for procedural sedation and with variable ratios of propofol and alfentanil.…”

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confidence: 99%

The effects of a propofol/alfentanil admixture on total intravenous anaesthesia in dogs undergoing splenectomy

Jia¹,

Zhao²,

Wang³

et al. 2015

Vet. Med. - Czech

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ABSTRACT:The aim of this study was to compare the cardiovascular and respiratory effects and the bispectral scale index (BIS) as well as the recovery period characteristics in response to treatment with a propofol/alfentanil admixture of different concentrations in dogs undergoing splenectomy. We conducted a prospective, randomised, blinded experimental trial. Anaesthesia was induced and maintained by continuous-infusion anaesthesia of propofol and alfentanil or a propofol/alfentanil admixture after premedication with acepromazine (0.03 mg/kg). Dogs were assigned to receive different concentrations of the admixture. Changes in BIS value, heart rate (HR), respiratory rate (f R ), non-invasive arterial blood pressure, pulse oximetry (SpO 2 ), end-tidal carbon dioxide concentrations (ETCO 2 ) and rectal temperature (RT) were recorded at predefined time points during anaesthesia. Data [mean ± standard deviation (SD)] were analysed by analysis of variance (ANOVA) for repeated measures followed by a Dunnett's test and Student's t-test (P < 0.05) and where necessary, the Mann-Whitney U-test. No significant differences were found between groups with respect to age, body mass, SpO 2 , ETCO 2 , f R , systolic, diastolic and mean arterial blood pressure (SAP, DAP and MAP). BIS values were significantly lower in Group 2 when compared to Group 1 at T7, T8, T9. The HR of Group 2 was significantly lower at T2 to T9 when compared to Group 1. The propofol and alfentanil admixture provided satisfactory results in dogs undergoing splenectomy. Thus, an admixture of propofol/alfentanil may be used for total IV anaesthesia in dogs at the infusion rates determined in this study.

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“…The safety and stability of propofol combination have been documented (Auckburally et al, 2008;Padilha et al, 2011). Moreover, drug combinations typically reduce the dose of general anaesthesia or other anaesthetic which may be beneficial in certain situations (Smischney et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Comparative Evaluation of Haemato- Biochemical Profiles in Atropinized Dogs Premedicated with Pentazocine or Meperidine in Propofol Anaesthesia

Anandmay¹,

Sharma²,

Ram³

et al. 2017

Int. J. Livest. Res.

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A Clinical Comparison of Remifentanil or Alfentanil in Propofol-Anesthetized Cats Undergoing Ovariohysterectomy

Cited by 9 publications

References 19 publications

Evaluation and optimisation of propofol pharmacokinetic parameters in cats for target‐controlled infusion

Evaluation and optimisation of propofol pharmacokinetic parameters in cats for target‐controlled infusion

The effects of a propofol/alfentanil admixture on total intravenous anaesthesia in dogs undergoing splenectomy

Comparative Evaluation of Haemato- Biochemical Profiles in Atropinized Dogs Premedicated with Pentazocine or Meperidine in Propofol Anaesthesia

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