A Clinical Evaluation of a New Anticholinergic Drug, Pro-Banthine

Schwartz, I. Richard; Lehman, Edward; Ostrove, R.; Seibel, Jan

doi:10.1016/s0016-5085(19)36242-0

Cited by 17 publications

(3 citation statements)

References 7 publications

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“…Propantheline decreases the motility of the gastrointestinal tract (Schwartz, Lehman, Ostrove & Seibel, 1953), while metoclopramide stimulates gastrointestinal activity and increases rate of transit (Eisner, 1968;Margieson, Sorby & Williams, 1966;James & Hume, 1968). It is likely that their effects upon absorption of digoxin from formulations of large particle size are secondary to altered rate of transit of digoxin through the intestine, which must affect the time available for dissolution of digoxin particles in intestinal fluids.…”

Section: Discussionmentioning

confidence: 99%

The influence of digoxin particle size on absorption of digoxin and the effect of propantheline and metoclopramide.

Johnson¹,

O’Grady²,

Bye³

1978

Brit J Clinical Pharma

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1 The influence of particle size on absorption of digoxin was studied in ten healthy volunteers who received 0.5 mg digoxin as two standard Lanoxin tablets, or tablets containing micronized digoxin or large particle size digoxin. Tablets were given 30 min after 15 mg propantheline, 10 mg metoclopramine or a placebo tablet, and following an overnight fast. 2 The overall mean cumulative 4 day urinary excretion of digoxin was significantly lower (P less than 0.01) after large particle size digoxin than after standard or micronized digoxin. Mean cumulative urinary excretion following large particle size digoxin was reduced when administered after metoclopramide and increased after propantheline, the difference between these two treatments being significant (P less than 0.05). There was a significantly lower (P less than 0.05) overall mean cumulative excretion following standard by comparison with micronized digoxin. However, by comparison with placebo, neither metoclopramide nor propantheline significantly altered mean cumulative excretion after standard or micronized digoxin. Propantheline and metoclopramide affect absorption of digoxin from formulations of large particle size and slow dissolution rate only.

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Section: Discussionmentioning

confidence: 99%

The influence of digoxin particle size on absorption of digoxin and the effect of propantheline and metoclopramide.

Johnson¹,

O’Grady²,

Bye³

1978

Brit J Clinical Pharma

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“…Antimuscarinic drugs such as atropine (Hilton & Lewis, 1955;Kay & Smith, 1956), propantheline (Kraines, 1957;Schwartz et al, 1953) and mepenzolate (Kleckner, 1957;Kraines, 1957) have been shown to reduce gastric emptying and salivary flow rates. Pirenzepine (a pyridobenzodiazepine compound) is an antimuscarinic drug used in the treatment of peptic ulceration.…”

Section: Introductionmentioning

confidence: 99%

The effect of pirenzepine on gastric emptying and salivary flow rate: constraints on the use of saliva paracetamol concentrations for the determination of paracetamol pharmacokinetics.

Kamali

Edwards

Rawlins

1992

Brit J Clinical Pharma

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1 The effects of pirenzepine on gastric emptying, salivary flow and saliva paracetamol concentrations were investigated in healthy volunteers. 2 Pirenzepine significantly reduced the area under the saliva flow-time curves (7.29 + 3.30 g min-' h without pirenzepine; 4.19 + 2.59 g min-' h with pirenzepine, P < 0.01).Pirenzepine had no significant effect on plasma paracetamol Cma (17.5 ± 7.8 pug mr1 without pirenzepine; 12.6 ± 7.7 ,ug ml-' with pirenzepine), plasma tmax (0.2 h (0.2-0.8 h) without pirenzepine; (0.2 h 0.2-0.8 h) with pirenzepine) and plasma AUC(0,6 h) (32.3 ± 7.2 pg ml-' h without pirenzepine; 30.3 ± 6.5 ,ug ml-' h with pirenzepine).3 Mean ratios of saliva:plasma paracetamol AUC (1.06 ± 0.24 without pirenzepine;1.84 ± 0.48 with pirenzepine, P < 0.001) and saliva:plasma paracetamol Cmax (1.7 ± 1.0 without pirenzepine; 6.5 ± 2.7 with pirenzepine, P < 0.01) were significantly increased by pirenzepine pretreatment, but there was a poor correlation between the percentage change in the area under the saliva flow-time curve and the percentage change in saliva paracetamol AUC (r = 0.47, P = 0.21). 4 The findings suggest that a) pirenzepine is a more selective antagonist of the muscarinic receptors in salivary glands than those in gastric smooth muscle and b) caution is required when using saliva paracetamol concentrations to determine the pharmacokinetics of the drug in the presence of other agents which may influence salivary flow rate.

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“…Clinically, Barowsky (3) observed no side‐effects in any of 25 patients receiving the drug, even though it was administered over long periods of time. In a study of 156 patients, Schwartz and his co‐workers (4) noted only mild, occasional side‐effects from the prolonged administration of Pro‐Banthūne; these side‐effects (dryness of the mouth, blurring of vision and hesitancy of urination) seldom interfered with continuous administration and were reduced notably with adjustment of the dosage.…”

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confidence: 99%

Clinical Study With a New Hydrocholeretic Drug and a New Hydrocholeretic‐antispasmodic Combination

Settel

1959

J American Geriatrics Society

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Biliary-tract disorders today are common clinical occurrences, and they can be expected to become even more common in the near future. As Rizzo (1) points out, life expectancy is increasing, and the incidence of biliary disease increases with each decade of life. For this reason, attention has turned toward the more effective management of these disorders.Current medical management often includes the administration of 1) a hydrocholeretic to effect an increased flow of a clear, fluid bile; and 2) antispasmodic medication to reduce hypertonicity of the sphincter of Oddi and relieve the associated smooth muscle spasm.This report evaluates the clinical effectiveness of florantyrone (Zanehol'")', a new abstergent-hydrocholeretic, and a combination-(tablet) of this drug and the antispasmodic agent, Pro-Banthlne", in the treatment of various biliary disorders. Zanchol is a single, synthetic substance chemically described as /'-oxo-/'-(8-fluoranthene) butyric acid. Pro-Banthlne is a single, synthetic substance with the descriptive formula ,B-diisopropylaminoethyl xanthene-9-carboxylate methobromide.Extensive pharmacologic studies (2) on animals indicate that florantyrone is virtually nontoxic. Clinically, Barowsky (3) observed no side-effects in any of 25 patients receiving the drug, even though it was administered over long periods of time. In a study of 156 patients, Schwartz and his co-workers (4) noted only mild, occasional side-effects from the prolonged administration of Pro-Banthlne; these side-effects (dryness of the mouth, blurring of vision and hesitancy of urination) seldom interfered with continuous administration and were reduced notably with adjustment of the dosage. METHODThe 36 patients in the present study were divided into 4 diagnostic groups: 19 patients with chronic cholecystitis and cholangitis, 9 with biliary dyskinesia, 5 with the postcholecystectomy syndrome, and 3 with biliary constipation. They were further divided into a middle-aged group (20 patients aged 35--60 years) and a geriatric group (16 patients aged 61-86 years).Biliary-tract disease had been present, with or without associated hepatic dysfunction, for periods ranging from three months to twenty-five years. Roentgenologic evidence of biliary-tract disease was present in more than two-thirds of the 36 patients.Florantyrone was administered as 250-mg. tablets of Zanchol in a dosage of 1 tablet three or four times daily. This dosage was doubled when a greater response was desired. When

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A Clinical Evaluation of a New Anticholinergic Drug, Pro-Banthine

Cited by 17 publications

References 7 publications

The influence of digoxin particle size on absorption of digoxin and the effect of propantheline and metoclopramide.

The influence of digoxin particle size on absorption of digoxin and the effect of propantheline and metoclopramide.

The effect of pirenzepine on gastric emptying and salivary flow rate: constraints on the use of saliva paracetamol concentrations for the determination of paracetamol pharmacokinetics.

Clinical Study With a New Hydrocholeretic Drug and a New Hydrocholeretic‐antispasmodic Combination

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