2000
DOI: 10.1177/026765910001500602
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A clinical evaluation of platelet function, haemolysis and oxygen transfer during cardiopulmonary bypass comparing the Quantum HF-6700 to the HF-5700 hollow fibre membrane oxygenator

Abstract: The continued improvement of oxygenators is an important aspect of patient safety during cardiopulmonary bypass (CPB). The purpose of this study was to compare the Bard William Harvey HF-5700 oxygenator to the upgraded Bard Quantum HF-6700, which has recently been introduced into clinical practice. No clinical evaluation of this device has been published to date. The two oxygenators differ principally in that the Quantum has a smaller priming volume, achieved at the expense of a smaller membrane surface area w… Show more

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Cited by 11 publications
(12 citation statements)
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“…The haptoglobin response during CPB is variable with most studies indicating a decrease in haptoglobin concentrations,(7, 25, 26) while in another study haptoglobin concentrations remained within normal limits at the end of CPB. (27) The haptoglobin response observed in our study may in part be explained by the administration of pre-bypass steroids that can induce haptoglobin synthesis as well as plasma priming of the pump that resulted in higher intraoperative haptoglobin concentrations.…”
Section: Discussionmentioning
confidence: 70%
“…The haptoglobin response during CPB is variable with most studies indicating a decrease in haptoglobin concentrations,(7, 25, 26) while in another study haptoglobin concentrations remained within normal limits at the end of CPB. (27) The haptoglobin response observed in our study may in part be explained by the administration of pre-bypass steroids that can induce haptoglobin synthesis as well as plasma priming of the pump that resulted in higher intraoperative haptoglobin concentrations.…”
Section: Discussionmentioning
confidence: 70%
“…are associated with intravascular hemolysis, and consequently there is the potential risk for the development of pulmonary hypertension, such as schistosomiasis (3,4), and iatrogenic hemolysis from mechanical heart valves (5, 6), left ventricular assist devices, and cardiopulmonary bypass procedures (7)(8)(9)(10)(11). Importantly, there are no case reports of pulmonary hypertension complicating iron deficiency anemia, the most common anemia in the world, suggesting a requirement for intravascular hemolysis for the development of this complication.…”
Section: What This Study Adds To the Fieldmentioning
confidence: 99%
“…In support of the role of haemolysis as an important contributing mechanism in this disorder, pulmonary arterial hypertension is an increasingly recognized complication of other chronic hereditary and acquired haemolytic anaemias including thalassaemia intermedia and major (Aessopos et al , 1995, 2001; Koren et al , 1987; Grisaru et al , 1990; Jootar & Fucharoen, 1990; Du et al , 1997; Finazzo et al , 1998; Derchi et al , 1999; Merault et al , 2000; Zakynthinos et al , 2001; Hahalis et al , 2002; Littera et al , 2002; Taher et al , 2002; Atichartakarn et al , 2003), paroxysmal nocturnal haemoglobinuria (Heller et al , 1992; Uchida et al , 1998), hereditary spherocytosis and stomatocytosis (Verresen et al , 1991; Stewart et al , 1996; Hayag‐Barin et al , 1998; Jais et al , 2003; Murali et al , 2003; Jardine & Laing, 2004), microangiopathic haemolytic anaemias (Stuard et al , 1972; McCarthy & Staats, 1986; Jubelirer, 1991; Suzuki et al , 1997; Labrune et al , 1999; Fischer et al , 2000; Alvarez Navascues & Marin, 2001), pyruvate kinase deficiency (Chou & DeLoughery, 2001), and possibly malaria (Huchzermeyer, 1988; Saissy et al , 2003). Additionally, certain conditions are associated with both intravascular haemolysis and risk of pulmonary hypertension, such as schistosomiasis (Strauss et al , 1986; de Cleva et al , 2003), and iatrogenic haemolysis from mechanical heart valves (Kyllonen et al , 1976; Iwaki et al , 2003), left ventricular assist devices and cardiopulmonary bypass procedures (Takami et al , 1996; Chukwuemeka et al , 2000; Pierangeli et al , 2001; Gerrah et al , 2003; Philippidis et al , 2004).…”
Section: Haemolysismentioning
confidence: 99%