A clinical evaluation of skin tags in relation to obesity, type 2 diabetis mellitus, age, and sex

Safoury, Omar Soliman El; Ibrahim, M.M.

doi:10.4103/0019-5154.84765

Cited by 22 publications

(24 citation statements)

References 18 publications

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“…While in study done by Omar et. Al 5 , the mean number of medium size skin tags was significantly higher in diabetic participants than non diabetics (p = 0.003). Skin tags are related to obesity, 9 and a hormonal mechanism has been suggested in obese females especially those with upper body obesity, where there is increased peripheral aromatization of androgens to estrogen.…”

Section: Discussionmentioning

confidence: 99%

“…The study done by Omar et al showed that the prevalence of Skin tags were more among diabetic patients. 5 Similarly, study of Demir et al 7 showed that patients with skin tags were found to have overt DM. They found diabetes in 73.3% of patients.…”

Section: Discussionmentioning

confidence: 99%

“…4 Diabetes Mellitus (DM) is a group of metabolic disease characterized by hyperglycemia resulting from defects in insulin secretion, insulin action or both. 5 We conducted this study to show that like other risk factors, diabetes mellitus may be associated with acrochordons, thereby indicating acrochordons may be one of the skin markers for diabetes mellitus.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Acrochordons and diabetes mellitus: A Case control study

Shrestha¹,

Poudyal

Rajbhandari

2016

Nepal J Dermatol Venereol & Leprol

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Acrochordons and diabetes mellitus: A Case control study

Shrestha¹,

Poudyal

Rajbhandari

2016

Nepal J Dermatol Venereol & Leprol

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“…Część badaczy uważa, że mogą być one użytecznym objawem wskazującym na zwiększone ryzyko rozwoju miażdżycy [7,[9][10][11]. W pracy Shah i wsp.…”

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“…Podobnie jak w poprzednim badaniu frakcja HDL cholesterolu w surowicy była obniżona, a pacjenci mieli wyższe skurczowe i rozkurczowe ciśnienie krwi [13]. W badaniu przeprowadzonym przez Demir i Demir zdiagnozowano cukrzycę aż u 73,3% pacjentów mających włókniaki [14], natomiast El Safoury i Ibrahim stwierdzili związek ich liczby przede wszystkim z otyłością i wiekiem, niezależnie od płci [10]. Potwierdza to badanie Gómez i wsp.…”

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Skin tags as a symptom of metabolic disorders

Owczarczyk‐Saczonek¹,

Placek²

2016

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Przegląd Dermatologiczny 2016/3 STRESZCZENIEWłókniaki miękkie są zaliczane do nowotworów łagodnych. Stwierdza się je głównie na skórze szyi, powiek, w okolicach pachowych i w pachwinach. Mają postać uszypułowanych, miękkich guzków. Ich występowanie wiąże się z otyłością, insulinoopornością, lipidemią aterogenną, czyli cechami zespołu metabolicznego. Są objawem wskazującym na zwiększone ryzyko rozwoju miażdżycy. Za czynniki wyjaśniające ich powstawanie uznaje się stymulację receptorów na keratynocytach i fibroblastach przez leptynę i insulinooporność towarzyszącą otyłości (IGF-1), a także przez androgeny i estrogeny, których gospodarka ulega zaburzeniu w otyłości. Dodatkowo receptory te są pobudzane przez tryptazę uwalnianą z komórek tucznych w wyniku urazów mechanicznych. Prawdopodobnie rolę kofaktorów odgrywają HPV. Piśmiennictwo dermatologiczne nie poświęca zbyt wiele miejsca tej tematyce, dlatego zamiarem autorów jest zwrócenie uwagi specjalistom naszej dziedziny na związek pomiędzy występowaniem włókniaków a rozwojem zaburzeń metabolicznych. ABSTRACTSkin tags are classified as benign lesions. They occur mainly on the skin of the neck, eyelids, armpits, and groin as pedicles and soft nodules. Their occurrence is associated with obesity, insulin resistance, atherogenic lipidemia, and metabolic syndrome, as well as increased risk of atherosclerosis. In the pathogenesis factors which are impaired in obesity, such as leptin, insulin resistance associated with obesity (IGF-1), androgens and estrogens believed to stimulate the receptors on keratinocytes and fibroblasts to grow, may play a role. In addition, these receptors are stimulated by tryptase released from the mast cells by mechanical injuries. Probably HPV plays a role as a cofactor. The dermatological literature does not provide much information about this subject, so the authors draw attention to the link between the presence of skin tags and the development of metabolic disorders. SŁOWA KLUCZOWE:otyłość, insulinooporność, włókniaki.

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Skin Manifestations of Insulin Resistance: From a Biochemical Stance to a Clinical Diagnosis and Management

González-Saldivar

Rodríguez-Gutiérrez

Ocampo‐Candiani

et al. 2016

Dermatol Ther (Heidelb)

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Worldwide, more than 1.9 billion adults are overweight, and around 600 million people suffer from obesity. Similarly, ~382 million individuals live with diabetes, and 40–50% of the global population is labeled at “high risk” (i.e., prediabetes). The impact of these two chronic conditions relies not only on the burden of illnesses per se (i.e., associated increased morbidity and mortality), but also on their increased cost, burden of treatment, and decreased health-related quality of life. For this review a comprehensive search in several databases including PubMed (MEDLINE), Ovid EMBASE, Web of Science, and Scopus was conducted. In both diabetes and obesity, genetic, epigenetic, and environmental factors overlap and are inclusive rather than exclusive. De facto, 70–80% of the patients with obesity and virtually every patient with type 2 diabetes have insulin resistance. Insulin resistance is a well-known pathophysiologic factor in the development of type 2 diabetes, characteristically appearing years before its diagnosis. The gold standard for insulin resistance diagnosis (the euglycemic insulin clamp) is a complex, invasive, costly, and hence unfeasible test to implement in clinical practice. Likewise, laboratory measures and derived indexes [e.g., homeostasis model assessment of insulin resistance (HOMA-IR-)] are indirect, imprecise, and not highly accurate and reproducible tests. However, skin manifestations of insulin resistance (e.g., acrochordons, acanthosis nigricans, androgenetic alopecia, acne, hirsutism) offer a reliable, straightforward, and real-time way to detect insulin resistance. The objective of this review is to aid clinicians in recognizing skin manifestations of insulin resistance. Diagnosing these skin manifestations accurately may cascade positively in the patient’s health by triggering an adequate metabolic evaluation, a timely treatment or referral with the ultimate objective of decreasing diabetes and obesity burden, and improving the health and the quality of care for these patients.

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A clinical evaluation of skin tags in relation to obesity, type 2 diabetis mellitus, age, and sex

Cited by 22 publications

References 18 publications

Acrochordons and diabetes mellitus: A Case control study

Acrochordons and diabetes mellitus: A Case control study

Skin tags as a symptom of metabolic disorders

Skin Manifestations of Insulin Resistance: From a Biochemical Stance to a Clinical Diagnosis and Management

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