A clinical history of Zincum metallicum: homeopathic pathogenetic trials and case reports

Waisse, Silvia; Jurj, Gheorghe

doi:10.1016/j.homp.2017.01.004

Cited by 5 publications

(6 citation statements)

References 5 publications

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“…Silvia Waisse and Gheorghe Jurj trace the clinical use of Zincum in homeopathy: they located twenty-three reports of homeopathic pathogenetic trials of Zincum metallicum in the 19 th century literature. 8…”

Section: Zincummentioning

confidence: 99%

No smoke without fire

Fisher¹

2017

Homeopathy

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Section: Zincummentioning

confidence: 99%

No smoke without fire

Fisher¹

2017

Homeopathy

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“…The homeopathic medicine Zincum metallicum is used for the treatment of neurological and behavioral symptoms, including: weakening of intellectual functions with brain and nervous exhaustion, loss of vitality, slow comprehension, memory disorder, general tremor and constant movements 23,24 . These alterations can be characterized as stress-related phenomena in different species.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the effects of Zincum metallicum in maternal deprivation-induced behavioral disturbances in female rats

Coelho¹,

Motta²,

Arrifano³

et al. 2021

Int J High Dilution Res

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Background: Clinical studies have shown that adverse events in early life are quite stressful and can lead to the development of psychiatric disorders, such as anxiety, in adolescence and adulthood in humans. Experimental models of maternal deprivation (MD) in rats can be a useful tool for the understanding how these events in the early period of development can lead to behavioral changes in adulthood. Aims: The objective of this study was to evaluate the long-term effects of Zincum metallicum (Zinc met) homeopathic treatment in rats subjected to maternal deprivation (MD) in their early days of life. Methods: Newborn female rats were subjected to MD during 10 days, one hour per day, from PND10 to PND21, and treated from the 10th day of lactation (PND10) up to weaning (PND21). On the PND21 the rats were divided in 4 groups (N=8): a) treated with Zinc met 30c; b) treated with Zinc met 6c; c) treated with 10% hydroalcoholic solution (HS); and “blank control”, rats without any treatment nor experienced deprivation (ND). The medicines were administered in blind trials, identified by codes. The animals were weighed weekly, from weaning until the end of the experiment, and evaluated in the Open Field (OF) and in the Elevated Plus Maze (EPM) devices, to evaluate mobility, emotionality and anxiety, in 3 moments of life: in PND21 (childhood), during puberty (PND 40) and adulthood (PND75). Data were analyzed statistically by ANOVA, followed by the Bonferroni's Multiple Comparison Test, being p?0.05. Results: 1) relative to ND group the Zinc met 6c showed reduced body weight while no differences were observed between the other groups; 2) In the OF, the MD group showed increased rearing behavior at PND 40. The Zinc met 6c group reversed this effect showing similar profile as the ND group. Moreover, Zinc met 6c group showed increase in the immobility time at this age; 3) In the EPM, the MD group showed increased time in closed arms and decreased head dips relative to ND group in PND21 period of observation. Treatment with Zinc met 6c but not with Zinc met 30c was effective to reduce this anxiety-like behavior in PND21. Conclusion: According to the proposed model, Zincum metallicum 6c seems to be able to prevent in anxiety-like behavior induced by maternal deprivation in the childhood, mainly in behavioral models related to anxiety. However, other studies still need to be developed to understand the physio-pathological basis of these effects.

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“…25 For this reason, we chose to elucidate cell mechanisms of two homeopathic medicines used for treatment of chronic infections: Silicea terra (Sil, prepared from pure flint) [26][27][28] and Zincum metallicum (Zinc, metallic zinc), 29 which present in the respective materia medica some features seen in diseases caused by bacteria of the genus Mycobacterium, such as necrotic and persistent lesions and excoriation with persistent scab. 28,30 Several biological and physical-chemical aspects of Zinc were recently elucidated in a multi-center study, [29][30][31][32][33] including effects on macrophage activity in vitro, such as fine modulation of hydrogen peroxide and cytokine synthesis. 20,33 In turn, Sil was associated with increased production of platelet-activating factor by activated macrophages.…”

Section: Introductionmentioning

confidence: 99%

Silicea terra and Zincum metallicum Modulate the Activity of Macrophages Challenged with BCG In Vitro

et al. 2020

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Background The homeopathic medicines Silicea terra (Sil) and Zincum metallicum (Zinc) modulate macrophage activity and were assessed in an experimental study in-vitro for their effects on macrophage–BCG (Bacillus Calmette–Guérin) interaction. Methods RAW 264.7 macrophages were infected with BCG, treated with different potencies of Sil and Zinc (6cH, 30cH and 200cH) or vehicle, and assessed 24 and 48 h later for bacilli internalization, hydrogen peroxide (H2O2) and cytokine production, and lysosomal activity. Results Treatment with vehicle was associated with non-specific inhibition of H2O2 production to the levels exhibited by uninfected macrophages. Sil 200cH induced significant reduction of H2O2 production (p < 0.001) compared with the vehicle and all other treatments, as well as higher lysosomal activity (p ≤ 0.001) and increased IL-10 production (p ≤ 0.05). Such effects were considered specific for this remedy and potency. The number of internalized bacilli was inversely proportional to Zinc potencies, with statistically significant interaction between dilution and treatment (p = 0.003). Such linear-like behavior was not observed for Sil dilutions: peak internalization occurred with the 30cH dilution, accompanied by cellular degeneration, and IL-6 and IL-10 increased (p ≤ 0.05) only in the cells treated with Sil 6cH. Conclusion Sil and Zinc presented different patterns of potency-dependent effect on macrophage activity. Bacterial digestion and a balanced IL-6/IL-10 production were related to Sil 6cH, though reduced oxidative stress with increased lysosomal activity was related to Sil 200cH. Degenerative effects were exclusively related to Sil 30cH, and potency-dependent phagocytosis was related only to Zinc.

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A clinical history of Zincum metallicum: homeopathic pathogenetic trials and case reports

Cited by 5 publications

References 5 publications

No smoke without fire

No smoke without fire

Assessment of the effects of Zincum metallicum in maternal deprivation-induced behavioral disturbances in female rats

Silicea terra and Zincum metallicum Modulate the Activity of Macrophages Challenged with BCG In Vitro

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