The central lines placement are associated with infectious, mechanic and thrombotic complications [2,3]. The associated infections represent serious consequences in morbidity, mortality and hospitalization cost for the patients and their families [4,5]. The objective of this study was to clarify the incidence, risk factors and more frequents pathogens for bacteremia and secondary infections associated with central lines in the medical or surgical patients in the Hospital Angeles Metropolitano in México between 2014 and 2017.