A clinical predictive model for live birth in women of advanced age undergoing PGT cycles

Bercovich, Or; Klar, Galia; Shaulov, Talya; Almog, Benny; Kalma, Yael; Rahav, Roni; Azem, Foad; Malcov, Mira; Cohen, Yoni

doi:10.1007/s00404-023-07329-6

Arch Gynecol Obstet

2024

DOI: 10.1007/s00404-023-07329-6

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A clinical predictive model for live birth in women of advanced age undergoing PGT cycles

Or Bercovich,

Galia Klar,

Talya Shaulov

et al.

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2024

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Current research status and clinical applications of noninvasive preimplantation genetic testing: A review

Yang,

Xu,

Zhuang

et al. 2024

Medicine

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Noninvasive preimplantation genetic testing (ni-PGT) is conducted by obtaining genetic information from embryos through the analysis of free DNA released by embryos in spent embryo culture medium or blastocoel fluid. Compared to conventional preimplantation genetic testing relying on trophectoderm biopsy, ni-PGT is characterized by its noninvasiveness. It has demonstrated early advancements in the detection of embryonic chromosomal aneuploidies and the diagnosis of monogenic diseases, showcasing considerable potential for clinical application. However, there are substantial controversies in the literature concerning the reliability of ni-PGT, the source of cell-free DNA, and maternal contamination. This paper elaborates on the principles, research advancements, effectiveness, and limitations of ni-PGT to provide a basis for clinical applications.

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Current research status and clinical applications of noninvasive preimplantation genetic testing: A review

Yang,

Xu,

Zhuang

et al. 2024

Medicine

View full text Add to dashboard Cite

show abstract

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A clinical predictive model for live birth in women of advanced age undergoing PGT cycles

Cited by 1 publication

References 15 publications

Current research status and clinical applications of noninvasive preimplantation genetic testing: A review

Current research status and clinical applications of noninvasive preimplantation genetic testing: A review

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