A Clinical Profile of Hepatitis A Patients in Jakarta, Indonesia

Adiwinata, Randy; Kristanto, Andi; Richard, Timoteus; Edbert, Daniel; Angelina, Frida; Eppy, Eppy; Mauleti, Ifael Y.; Lardo, S.; Firmansyah, Iman; Bur, Rika; Ahimsa, Titos; Nelwan, Erni Juwita

doi:10.7454/msk.v21i1.4610

Cited by 1 publication

(3 citation statements)

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“…Hepatitis A has a wide spectrum of clinical manifestations from asymptomatic to fulminant 16 . Chief complaints of abdominal pain, jaundice, and vomiting in the non-prolonged group is the classic manifestations of acute hepatitis A due to intrahepatic inflammation which impairs conjugated bilirubin transportation, leading to the accumulation of bilirubin in the skin and sclera 16 . This finding is similar to a British study that showed leading manifestations of jaundice, abdominal pain, and vomiting in hospitalized children with a median LOS of 1 day (0-7) 17 .…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, our study showed that paediatric hepatitis A patients with dark urine were 81% less likely to have a prolonged duration of stay. Appearance of dark urine is commonly found in the acute phase (within a few days to a week) due to the presence of bilirubin in the urine 15,16 and we hypothesized that patients who presented with this symptom might had been diagnosed with hepatitis sooner, therefore could be treated sooner as well. This might explain why these patients were less likely to have a shorter period of hospitalization.…”

Section: Discussionmentioning

confidence: 99%

“…This might explain why these patients were less likely to have a shorter period of hospitalization. One study stated that prodromal symptoms such as fever, anorexia, nausea, vomiting, abdominal discomfort, malaise, and weakness precede the onset of dark urine 16 . However in our study, no prodromal symptoms were at a significant level in the bivariate analysis.…”

Section: Discussionmentioning

confidence: 99%

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Length of stay and hospitalisation rates in Indonesian patients with paediatric hepatitis A: 2015-2021

Andraina,

Juliansen,

Vanessa

et al. 2023

Sri Lanka J Child Health

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Objective: To describe the trend in hepatitis-A virus (HAV)-related hospitalisations in children and analyse the association of demographic, clinical and laboratory manifestations with length of stay (LOS) of HAV infection.Method: A retrospective study was conducted in Siloam Hospitals Indonesia. Inclusion criteria were hospitalised paediatric hepatitis A patients aged 3-17 years from 2015-2021. Another viral hepatitis was excluded. Total 58 samples were divided into non-prolonged group (LOS<5 days) and prolonged group (LOS≥5 days). Demographic data, clinical manifestations and laboratory parameters were collected and analysed using SPSS. Correlations with p <0.05 were considered significant.Results: Hospitalisation rate pattern showed two peaks in 2016 and in 2019. The monocyte-to-leucocyte ratio (MLR), blood urea nitrogen (BUN), and creatinine were significantly associated with LOS in bivariate analysis. Medians of MLR and BUN were higher in the prolonged group (0.23; 17) than in the non-prolonged group (0.19; 15.98). Median of creatinine was lower in the prolonged group (0.55) than in the non-prolonged group (0.74). Multivariate analysis found that dark urine was less likely to have a prolonged LOS (OR: 0.23; 95% CI 0.06-0.91, p = 0.04).Conclusions: Dark urine was a protective factor for prolonged LOS. Independently, higher BUN and higher MLR were risk factors for prolonged LOS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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