A Clinical, Radiologic, and Immunopathologic Study of Five Periorbital Intraosseous Cavernous Vascular Malformations

Werdich, Xiang Q.; Curtin, Hugh D.; Fay, Aaron

doi:10.1016/j.ajo.2014.07.004

Cited by 13 publications

(11 citation statements)

References 40 publications

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“…Only a few recently published papers analyze osseous vascular lesions as VM arising in the facial skeleton (56). Most reports or series are based on case reports or a small number of cases (57)(58)(59)(60). Indeed, the vast majority of orbital lesions are arising in soft tissues (5).…”

Section: Discussionmentioning

confidence: 99%

“…However, this classification has not yet been generally used (75,76). Only in recent analyses, it is pointed out that facial vascular lesions are often entities that should not be classified as hemangioma, but as VM (52,(56)(57)(58)(59)(60)(61)(62)(63)(64)(65)(66)(67)(68)(69)(70). The radiological criteria of the intraosseous lesions correspond to those that have been used to differentiate hemangiomas (59).…”

Section: Classification Of Vascular Lesionsmentioning

confidence: 99%

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Symptomatic Intraosseous Vascular Malformation of Infraorbital Rim: A Case Report With Literature Survey

et al. 2020

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Background/Aim: Intraosseous orbital hemangiomas or vascular malformations (VM) are rare. This report is intended to complement the experience of diagnosing and treating a rare vascular lesion at this site. Special attention is paid to threedimensional imaging and the morphological distinction between the two entities in this location. Case Report: A 54-year-old female was examined and surgically treated for an exophytic firm mass of the infraorbital, which had become palpable as a hard mass due to growth in size. At first, a bone tumor, for example, an osteoma, was suspected. Intraoperatively, an osseous expansion with distinct fenestrations of the newly grown bone's surface, was detected. The lesion was firmly attaching to the orbital rim. The densely vascularized tumor was well defined to the soft tissues but had grown in continuity from the orbital floor and rim. Vascularized cavities caused the tumor to have a slightly reddish color. The histological examination confirmed the suspicion of the lesion's vascular origin. The lesion's immunohistochemical expression profile approved the final diagnosis of intraosseous VM. Conclusion: The symptoms of intraosseous vascular lesions of the orbit are determined by location and size. Modern imaging techniques facilitate the estimation of tumor-like expansion of lesions. However, the imaging characteristics of intraosseous vascular lesions are very variable. The symptoms of the patient presented herein show that growth phases of a vascular orbital malformation can occur in later stages of life and are initially indistinguishable from a neoplasm. In individual cases, patient care necessitates advanced diagnostic measures to establish the diagnosis and determine surgical therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Classification Of Vascular Lesionsmentioning

confidence: 99%

Symptomatic Intraosseous Vascular Malformation of Infraorbital Rim: A Case Report With Literature Survey

et al. 2020

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“…Two cases (cases 14, 66) were treated by curettage, and recurrence occurred in one of them. In four cases (cases 43, [50,56,57]) no treatment was performed, in two of them excision was performed latter due to the increased size of the lesion. Intraoperative bleeding was minimal in almost all cases; marked bleeding was reported in three cases (cases 5, [27,32]).…”

Section: Resultsmentioning

confidence: 99%

“…Intra-osseous vascular anomalies are uncommon neoplasms accounting for less than 1 % of all osseous neoplasms. In craniofacial region, the highest incidence was reported in parietal bone followed by the mandible [3].…”

Section: Introductionmentioning

confidence: 99%

Computer guided resection and reconstruction of intra-osseous zygomatic hemangioma: Case report and systematic review of literature

Temerek

Ali

Shehab

2020

International Journal of Surgery Case Reports

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HighlightsIntraosseous zygomatic hemangioma is highly prevalent in females compared to males (2.28:1), with mean age of 44.1 ± 1.8 years.The main patient concern in intraosseous zygomatic hemangioma is swelling and facial deformity.Partial resection and curettage are associated with high recurrence rate.Total tumor resection can assure no recurrence proved for over 10 years of follow-up, with minimal intraoperative bleeding occurred in most of the cases.Computer guided surgery for resection and reconstruction of intraosseous zygomatic hemangioma facilitates the surgical procedures.

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“…This finding suggests that these lesions continue to proliferate, if slowly. There is sparse information on Ki67 reactivity in vascular malformations [18,19]. Possibly, in patients with FCCM specifically, the growth of current lesions and development of new lesions in the vertebrae may be ascribable in part to low ongoing proliferative capacity.…”

Section: Discussionmentioning

confidence: 99%

Vertebral Intraosseous Vascular Malformations in a Familial Cerebral Cavernous Malformation Population: Prevalence, Histologic Features, and Associations With CNS Disease

Tandberg

Bocklage

Bartlett

et al. 2020

American Journal of Roentgenology

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OBJECTIVE.-The purpose of this study was to investigate whether MRI-typical and MRIatypical intraosseous vascular malformations are associated with familial cerebral cavernous malformation (FCCM). MATERIALS AND METHODS.-In a retrospective matched case-control study, two radiologists reviewed the spinal imaging, both CT and MRI, of 22 patients with FCCM seen between 2006 and 2017 and of age-and sex-matched control subjects for MRI-typical and MRIatypical intraosseous vascular malformations. Quantitative analysis of lesions identified included vertebral level, size, and number of lesions. Pathologic samples from two lesions were analyzed for histologic and immunohistochemical features. Whether the presence of typical, atypical, and total intraosseous vascular malformations differed between patients and control subjects was tested. For patients with complete spinal imaging, whether intraosseous vascular malformations were associated with age, sex, brain lesion count, and spinal lesion count was also tested. RESULTS.-MRI-atypical intraosseous vertebral malformations were more commonly present in patients with FCCM (p = 0.003). Sixteen lesions were found in nine patients and none in the control group. The numbers of MRI-typical intraosseous vascular malformations were similar between patients and control subjects (p = 0.480). Age was associated with typical intraosseous vascular malformations (p = 0.027), though not with atypical malformations. MRI-atypical malformations were larger (mean diameter double) than MRI-typical malformations (p = 0.023). Histologic analysis of two lesions from different patients with pathologic collapse revealed the same histologic features consistent with combined capillary-venous malformations.

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A Clinical, Radiologic, and Immunopathologic Study of Five Periorbital Intraosseous Cavernous Vascular Malformations

Cited by 13 publications

References 40 publications

Symptomatic Intraosseous Vascular Malformation of Infraorbital Rim: A Case Report With Literature Survey

Symptomatic Intraosseous Vascular Malformation of Infraorbital Rim: A Case Report With Literature Survey

Computer guided resection and reconstruction of intra-osseous zygomatic hemangioma: Case report and systematic review of literature

Vertebral Intraosseous Vascular Malformations in a Familial Cerebral Cavernous Malformation Population: Prevalence, Histologic Features, and Associations With CNS Disease

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