A clinical study for the evaluation of pharmacokinetic interaction between daclatasvir and fluoxetine

Oraby, Mohamed; Khorshed, Ahmed A.; Abdulrahman, E.M.; Ali, Ramadan; Elsutohy, Mohamed M.

doi:10.1016/j.jpba.2019.03.065

Cited by 10 publications

(2 citation statements)

References 26 publications

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“…For this purpose practically is utilizing liver biopsy, concretly gold standard method.In adition, imaging modalities with or without noninvasive biomarkers also are practically important. [10][11][12] In HCV infection, a proper treatment is important in order to treat specifically each ill person. [13,14] From another perspective, oxidative stress is reported as an important part of HCV which produce liver alterations.…”

Section: Introductionmentioning

confidence: 99%

Laboratory techniques for hepatic diseases diagnosis

Chesca,

Medetova,

Abdulina

et al. 2023

Preprint

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The study aimed to manage and to analyse the results of the laboratory tests, routinallypractice for hepatitis C diagnosis, using blood tests. Statistical analysis of this study results, was performed using the laboratory informatic system. The results of the study are substantial and intricate reffering to comparision between two methods concretlly ELISA method (Enzyme-Linked Immunosorbent Assay) and chemiluminescence methods and their results. Good to know our opinion that RT-PCR technique, it is considered proper for the diagnosis of HCV ( Hepatitis C virus).

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Section: Introductionmentioning

confidence: 99%

Laboratory techniques for hepatic diseases diagnosis

Chesca,

Medetova,

Abdulina

et al. 2023

Preprint

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“…[ 2,3 ] Few analytical methods have been reported that determine the cited drug through spectroscopic techniques. The reported spectroscopic techniques for quantification of daclatasvir dihydrochloride are spectrophotometric, [ 4–7 ] spectrofluorimetric, [ 8–10 ] and Fourier transform infrared (FTIR) [ 11 ] methods. The reported spectrophotometric methods [ 6 ] measure the formed binary complex between daclatasvir dihydrochloride and bromothymol blue, bromocresol green, or bromophenol blue after extraction with a hazardous organic solvent (dichloroethane) or measure the native absorbance of daclatasvir dihydrochloride in methanol.…”

Section: Introductionmentioning

confidence: 99%

Applying different spectroscopic techniques for the selective determination of daclatasvir using merbromin as a probe: Applications on pharmaceutical analysis

Almahri

Abdel‐Lateef

2021

Luminescence

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In this study, rapid resonance Rayleigh scattering (RRS), spectrophotometric, and spectrofluorimetric methods were performed for facile quantitation of daclatasvir dihydrochloride without interference from sofosbuvir (a co‐formulated anti‐hepatitis C virus drug). The proposed approaches were based on forming a binary complex between daclatasvir dihydrochloride and merbromin reagent at pH 4.1. The binary complex was measured spectrophotometrically at λmax = 544 nm. The spectrofluorimetric approach relied on the quenching effect of daclatasvir dihydrochloride on the fluorescence strength of merbromin at λEmission = 545 nm. The RRS approach depended on augmentation in the merbromin RRS spectrum at 363 nm upon addition of daclatasvir dihydrochloride. The presented methodologies were linear over the concentration ranges 2.5−15.0, 0.2−1.6 and 0.15−3.0 μg ml−1 with detection limits of 0.45, 0.046, and 0.036 μg ml−1 for the spectrophotometric approach, the spectrofluorometric approach, and RRS approach, respectively. Current approaches were validated in compliance with International Council for Harmonisation guidelines and utilized practically to estimate daclatasvir dihydrochloride either in binary mixtures with sofosbuvir or in its commercial tablet dosage form with good results. Moreover, the test for content uniformity was applied successfully on commercial tablets using the current spectroscopic approaches.

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