A clinical study of 17 cases of malignant tumors metastatic to the mouth and jaws

Abstract

Metastatic tumors of the oral region are relatively rare and comprise approximately 1 % of malignant oral neoplasms. Their prognosis is generally very poor because of systemic metastases. We clinically studied 17 cases of metastatic tumors of the oral region. Fourteen of the 17 patients were male and 3 were female. The mean age was 56.6 years. Metastases to the mandible were twice as frequent as those to the maxilla. The most common location of the metastatic lesions was the molar region of the jaws. The most common symptom of metastatic lesions was swelling. Paresthesia of the mental nerve was present in 4 patients. The most common site of the primary tumor was the lung, followed by the colon. Histologically, adenocarcinomas had the far highest rate of metastasis to the oral region. If both the primary tumor and generalized metastasis are controlled, the oral tumor must be aggressively treated. However, when the primary tumor was controlled but generalized metastasis was uncontrolled, patients died within 6 months despite oral treatment. Patients with uncontrolled primary tumors died within 7 months despite oral control, except for one patient who survived 13 months.

Metastatic colon carcinoma in the maxilla: Highlighting the importance of perioperative oral management: A case report

“…Consistent with the findings in this case, metastatic tumors in the oral and maxillofacial regions are frequently encountered as multiple metastases and exhibit a high fatality rate ( 22 , 23 ). A comprehensive evaluation of the primary tumor and the presence or absence of metastases is crucial in determining an effective treatment plan.…”

“…The diagnostic criteria for metastatic tumors include the presence of a primary tumor or the absence of other tumor lesions (Tables II and III) (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32). Additionally, The histological similarity between the primary tumor and the metastases 3…”

Metastasis of pulmonary adenocarcinoma to the oral cavity: A case report and literatures review of the last 30 years

“…Several studies have recommended palliative treatment (e.g., surgical treatment, chemotherapy, and radiotherapy) to improve the quality of life (QOL) and to maintain the patient's comfort 7,8 . We found 54 cases of oral metastasis of PCs that were reported from 1991 to 2021 in PubMed and Google scholar 9–45 and reviewed these cases, including our case. Kaplan‐Meier survival analyses were performed to determine whether palliative treatment affected overall survival.…”

“…In our review, 41 of 54 patients received palliative treatments, and surgical treatments were common ( n = 10), followed by chemoradiotherapy ( n = 8) (Table 1). 8–44 There were no significant differences in the survival times between patients with and without palliative treatment at 6.49 and 4.36 months, according to the results of the Kaplan‐Meier test (log rank test: P = 0.437, Figure 4), which suggested that palliative treatment had no effect on survival time. Our patient was able to consume food orally using the upper denture after surgical treatment, showing that even if radical therapy cannot be administered, palliative treatment for maintaining oral function may contribute to the improvement of the QOL.…”

A Case Report of Mandibular Gingival Metastasis From Sigmoid Colon Adenocarcinoma With Phenotypical Transformation Into Neuroendocrine Carcinoma

“…All malignant tumors can metastasize to the oral cavity, but most often the primary tumor involves the lungs, kidneys, liver, and prostate gland in male patients and mammary glands, genitals, and kidneys in female patients [ 5 ]. Metastases in the maxillofacial region and the oral cavity are often multiple and are associated with a high mortality rate [ 9 , 10 ].…”