A Clinical Study of 213 Patients with Laryngeal Cancer

Miyata, Hiroshi; Yane, Katsunari; Tsuruta, Yoshihiro; Uemura, Hirokazu

doi:10.3950/jibiinkoka.105.790

Cited by 7 publications

(1 citation statement)

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“…The treatment approach for laryngeal cancer has been firmly established, and a five-year survival rate of more than 70 per cent is expected even for patients with advanced cancer 1 – 3 . However, in laryngeal cancer cases, cervical lymph node metastasis and distant metastasis are more frequently observed in patients with supraglottic than glottic carcinomas, and the former diagnosis is considered to lower patients' treatment prognosis.…”

Section: Introductionmentioning

confidence: 99%

Supraglottic carcinoma treatment results analysed by therapeutic approach

et al. 2009

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This study reviewed 161 patients with supraglottic squamous cell carcinoma who underwent radical therapy at Kurume University Hospital between 1989 and 2003. The five-year survival rate was 89 per cent in patients with stage III disease and 75 per cent in stage IV patients, thus demonstrating favourable results even for patients with advanced cancer. The five-year local control rate and the laryngeal preservation rate were poor in patients with T3 tumours (being 75 per cent for both), but the overall five-year local control rate for all patients was 86 per cent. Laser surgery plus chemo-radiotherapy was the most frequently used treatment. The local control rates and laryngeal preservation rates were poor in patients with tumour infiltration to the glottis and the laryngeal ventricle. In conclusion, the indications for combination laser therapy for supraglottic carcinoma should in future be extended, and the type and number of chemotherapy courses for this cancer should be further clarified.

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Section: Introductionmentioning

confidence: 99%

Supraglottic carcinoma treatment results analysed by therapeutic approach

et al. 2009

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Laryngeale Epitheldysplasie vs. laryngeale intraepitheliale Neoplasie

Dreyer

Glanz

2004

Der Pathologe

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Laryngeal cancer is the most frequent malignancy of the upper respiratory tract. Only the very early treatment of tumors or even of their precursor lesions will be both curative and organ preserving. Microsurgical techniques facilitate early detection and complete removal of limited lesions can be achieved quite frequently, but follow-up data for such lesions are difficult to obtain. The resulting lack of endpoint observations (i.e., malignant transformation, spontaneous involution) hampers the development, testing, and application of grading systems focusing on epithelial alterations, especially changes with only mild nuclear atypia and minimal structural alteration. Such lesions may be entirely benign or may indicate premalignant stages of well-differentiated carcinoma. For diagnosis we recommend a modified Kleinsasser's system to classify premalignant epithelial changes. Only the complete removal of suspicious lesions as far as possible or regular clinical follow-up in cases where complete removal cannot be achieved can prevent the development of advanced stage cancer.

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Clinical Study of Early Laryngeal Cancer

Nagatani

Mori²,

Udaka³

et al. 2007

Nippon Jibiinkoka Gakkai Kaiho

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We retrospectively analyzed 71 consecutive cases of early laryngeal cancer (stage I or II) that had undergone primary treatment in our department between 1999 and 2004. There were 68 males and 3 females, and their ages ranged from 40 to 85 years of age (average; 67.7 years). Eight patients had the supraglottic type, 61 had the glottic type, and 2 had the subglottic type. Chemoradiotherapy was performed as the primary treatment except in the patients with glottic T1a cancer, who received radiotherapy alone. The 5-year survival rates was 91.1% for glottic cancer (T1a: 100%, T1b: 92.3%, T2: 85.8%) and 75.0% for supraglottic cancer. The local control rate of glottic cancer was 79.6% (T1a: 80.0%, T1b: 74.0%, T2: 85.2%), and significantly higher than that of supraglottic cancer (56.2%, p < 0.05). The laryngeal preservation rate was 84.4% in glottic cancer (T1a: 100%, T1b: 76.9%, T2: 77.5%) and 58.3% in supraglottic cancer, and the difference between T1a and T2 glottic cancer was significant (p < 0.05). Local recurrence and cervical lymph node metastasis were seen in 9 patients and 6 patients, respectively. Distant metastasis occurred in 4 patients, all of whom had the glottic type. Four patients died of their disease, and distant metastasis was the major cause of death in 3 of them. These results indicate that additional treatment should be performed in cases in which radiotherapy/chemoradiotherapy is ineffective and that both in the early stages glottic and supraglottic cancers can be successfully treated by radiotherapy/chemoradiotherapy. The results also suggested that the survival of patients with early laryngeal cancer depends on whether they develop distant metastasis. Introduction of adjuvant chemotherapy to improve their prognosis remains to be assessed.

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A Clinical Study of 213 Patients with Laryngeal Cancer

Cited by 7 publications

References 1 publication

Supraglottic carcinoma treatment results analysed by therapeutic approach

Supraglottic carcinoma treatment results analysed by therapeutic approach

Laryngeale Epitheldysplasie vs. laryngeale intraepitheliale Neoplasie

Clinical Study of Early Laryngeal Cancer

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