A Clinical Study of Adult Japanese Encephalitis in the Chonnam District, Korea, During Summer of 1982 -A Difference between Improved and Expired Cases-

Bom, Hee Seung; Kang, Hyung Koo; Joh, Nam Joong; Kim, Sei Jong; Yoon, Chong Mann; Cho, Kun Kook; Park, Hong Bae

doi:10.3904/kjim.1986.1.1.21

Cited by 3 publications

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“…Whereas, less number of Japanese encephalitis/acute encephalitis syndrome in the adults (49/137, 35.8%) was likely due to the development of immunity, either by sub-clinical infections or by earlier vaccination [Sarkar et al, 2012c]. Similar to earlier studies, high grade fever was the common symptom in all the patients of both the age groups irrespective of their IgM positivity and RT-PCR positivity status [Bom et al, 1986;Kumar et al, 2006]. It has been observed that neck rigidity, convulsion and abnormal behavior were more likely to be present in the pediatricadolescent age group, whereas headache was found to be prominent in the adult age group, as reported by a recent study [Borah et al, 2011].…”

Section: Discussionsupporting

confidence: 80%

Japanese encephalitis associated acute encephalitis syndrome cases in West Bengal, India: A sero‐molecular evaluation in relation to clinico‐pathological spectrum

Sarkar

Datta

Pathak

et al. 2015

Journal of Medical Virology

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Japanese encephalitis (JE) is a major public health problem in Asia and worldwide and it is responsible mainly for viral acute encephalitis syndrome (AES). The sole etiologic agent of JE is Japanese encephalitis virus (JEV). Although JE/AES cases have been regarded traditionally as a disease of children, a growing number of patients with JE/AES cases are also seen in the adult age group every year in the state of West Bengal, India in spite of vaccination. Therefore, a systematic study was performed to differentiate and characterize the clinico-pathological parameters and viral diversity among the patients of different age groups. Viral diversity was also evaluated from the JE/AES cases, depending on their disease severity. A total of 441 JE/AES cases were included in this study. By MAC-ELISA, 111 samples were found JEV IgM positive and among the IgM negative cases, 26 samples were found RT-PCR positive against JEV infection. Neck rigidity, abnormal behavior, convulsion, protein in CSF, WBC in CSF, and aspartate transaminase in blood differed significantly among the patients of pediatric-adolescent and adult group in both IgM positive and RT-PCR positive cases. Viral diversity was increased significantly in the pediatric-adolescent group compared to adult patients. Interestingly, with the rise in disease severity the viral diversity was found to be increased among the patients, irrespective of their age distribution. Based on clinico-pathological parameters and analysis of viral diversity, it can be concluded that viral diversity which occurs naturally is likely to affect disease severity, especially in the patients of pediatric-adolescent group.

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Section: Discussionsupporting

confidence: 80%

Japanese encephalitis associated acute encephalitis syndrome cases in West Bengal, India: A sero‐molecular evaluation in relation to clinico‐pathological spectrum

Sarkar

Datta

Pathak

et al. 2015

Journal of Medical Virology

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“…[18][19][20] Fever was the most common feature in adult and pediatric in the present as well as earlier studies. 21,9 Neck rigidity, convulsion, seizure and abnormal behavior were more likely to be present in children (P < 0.05), whereas both headache and myalgia were prominent in adult. In various studies, seizures and convulsion have been reported in only 10-15% of adult compared to 62.2-80% of children.…”

Section: Discussionmentioning

confidence: 99%

“…In various studies, seizures and convulsion have been reported in only 10-15% of adult compared to 62.2-80% of children. 10,11,17,[21][22][23] But in one comparative study between adult and pediatric reported seizure to occur more in adult (62.2%) than children (56.7%). 17 The abnormalities in liver and renal function in both adult and pediatric patients in the present study in accord with the information gathered in published papers.…”

Section: Discussionmentioning

confidence: 99%

A comparison of clinical features of Japanese encephalitis virus infection in the adult and pediatric age group with Acute Encephalitis Syndrome

Borah

Dutta

Khan

et al. 2011

Journal of Clinical Virology

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“…Despite large variations observed in JE CFRs across time and space, currently there is no available country-specific CFR estimates for accurate mortality burden estimation. Reported JE CFRs were as low as 0% in Thailand in 1972[ 30 ], in Korea in 1982[ 31 ], in Japan in 1994[ 32 ], in India in 2004[ 33 ], and in Myanmar in 2013[ 34 ]. Reported JE CFRs were as high as 100% in Korea and India (estimates ranging from 1962–2006 [ 8 , 31 , 33 , 35 – 37 ]).…”

Section: Introductionmentioning

confidence: 99%

“…Reported JE CFRs were as low as 0% in Thailand in 1972[ 30 ], in Korea in 1982[ 31 ], in Japan in 1994[ 32 ], in India in 2004[ 33 ], and in Myanmar in 2013[ 34 ]. Reported JE CFRs were as high as 100% in Korea and India (estimates ranging from 1962–2006 [ 8 , 31 , 33 , 35 – 37 ]).…”

Section: Introductionmentioning

confidence: 99%

Estimates of Japanese Encephalitis mortality and morbidity: A systematic review and modeling analysis

et al. 2022

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Background Japanese Encephalitis (JE) is known for its high case fatality ratio (CFR) and long-term neurological sequelae. Over the years, efforts in JE treatment and control might change the JE fatality risk. However, previous estimates were from 10 years ago, using data from cases in the 10 years before this. Estimating JE disease severity is challenging because data come from countries with different JE surveillance systems, diagnostic methods, and study designs. Without precise and timely JE disease severity estimates, there is continued uncertainty about the JE disease burden and the effect of JE vaccination. Methodology We performed a systematic review to collate age-stratified JE fatality and morbidity data. We used a stepwise model selection with BIC as the selection criteria to identify JE CFR drivers. We used stacked regression, to predict country-specific JE CFR from 1961 to 2030. JE morbidity estimates were grouped from similar study designs to estimate the proportion of JE survivors with long-term neurological sequelae. Principal findings We included 82 and 50 peer-reviewed journal articles published as of March 06 2021 for JE fatality and morbidity with 22 articles in both analyses. Results suggested overall JE CFR estimates of 26% (95% CI 22, 30) in 1961–1979, 20% (95% CI 17, 24) in 1980–1999, 14% (95% CI 11, 17) in 2000–2018, and 14% (95% CI 11, 17) in 2019–2030. Holding other variables constant, we found that JE fatality risk decreased over time (OR: 0.965; 95% CI: 0.947–0.983). Younger JE cases had a slightly higher JE fatality risk (OR: 1.012; 95% CI: 1.003–1.021). The odds of JE fatality in countries with JE vaccination is 0.802 (90% CI: 0.653–0.994; 95% CI: 0.62–1.033) times lower than the odds in countries without JE vaccination. Ten percentage increase in the percentage of rural population to the total population was associated with 15.35% (95% CI: 7.71, 22.57) decrease in JE fatality odds. Ten percentage increase in population growth rate is associated with 3.71% (90% CI: 0.23, 7.18; 95% CI: -0.4, 8.15) increase in JE fatality odds. Adjusting for the effect of year, rural population percent, age of JE cases, and population growth rate, we estimated that there was a higher odds of JE fatality in India compared to China. (OR: 5.46, 95% CI: 3.61–8.31). Using the prediction model we found that, in 2000–2018, Brunei, Pakistan, and Timor-Leste were predicted to have the highest JE CFR of 20%. Bangladesh, Guam, Pakistan, Philippines, and Vietnam had projected JE CFR over 20% for after 2018, whereas the projected JE CFRs were below 10% in China, Indonesia, Cambodia, Myanmar, Malaysia, and Thailand. For disability, we estimated that 36% (min-max 0–85) JE patients recovered fully at hospital discharge. One year after hospital discharge, 46% (min-max 0%-97%) JE survivors were estimated to live normally but 49% (min-max 3% - 86%)till had neurological sequelae. Conclusion JE CFR estimates were lower than 20% after 2000. Our study provides an updated estimation of CFR and proportion of JE cases with long-term neurological sequelae that could help to refine cost-benefit assessment for JE control and elimination programs.

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A Clinical Study of Adult Japanese Encephalitis in the Chonnam District, Korea, During Summer of 1982 -A Difference between Improved and Expired Cases-

Cited by 3 publications

References 0 publications

Japanese encephalitis associated acute encephalitis syndrome cases in West Bengal, India: A sero‐molecular evaluation in relation to clinico‐pathological spectrum

Japanese encephalitis associated acute encephalitis syndrome cases in West Bengal, India: A sero‐molecular evaluation in relation to clinico‐pathological spectrum

A comparison of clinical features of Japanese encephalitis virus infection in the adult and pediatric age group with Acute Encephalitis Syndrome

Estimates of Japanese Encephalitis mortality and morbidity: A systematic review and modeling analysis

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