A clinical study of pulmonary manifestations in systemic lupus erythematosus with special reference to CT findings

Kakati, Sanjeeb; Doley, B; Dihingia, Prasanta; Pegu, UR; S, Pal; Deka, U J

doi:10.1016/s0973-3698(10)60056-8

Cited by 18 publications

(12 citation statements)

References 12 publications

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“…Plain film chest X-rays (CXRs) have traditionally been used to assess for lung involvement in JSLE, but studies show they detect abnormalities at around half the rate of PFTs with DLCO 20 21. PFTs commonly measured include FVC, FEV1 and FEV1/FVC ratio.…”

Section: Juvenile Systemic Lupus Erythematosusmentioning

confidence: 99%

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Respiratory complications of the rheumatological diseases in childhood

2016

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Pleuropulmonary manifestations of rheumatological diseases are rare in children but pose a significant risk to overall morbidity and mortality. We have reviewed the literature to provide an overview of the respiratory complications of the commonest rheumatological diseases to occur in children (juvenile systemic lupus erythematosus, scleroderma, juvenile dermatomyositis, mixed connective tissue disease, granulomatosis with polyangitis and juvenile idiopathic arthritis). Pulmonary function testing in these patients can be used to refine the differential diagnosis and establish disease severity, but also has a role in ongoing monitoring for respiratory complications. Early detection of pulmonary involvement allows for prompt and targeted therapies to achieve the best outcome for the child. This is best achieved with joint specialist paediatric rheumatology and respiratory reviews in a multidisciplinary setting.

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Section: Juvenile Systemic Lupus Erythematosusmentioning

confidence: 99%

“…PFTs commonly measured include FVC, FEV1 and FEV1/FVC ratio. A restrictive pattern in JSLE is the most commonly seen abnormality 20. DLCO is decreased in obstructive airways disease, pulmonary vascular disease and, importantly, ILD.…”

Section: Juvenile Systemic Lupus Erythematosusmentioning

confidence: 99%

Respiratory complications of the rheumatological diseases in childhood

2016

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“…There are only few studies investigating pulmonary function of asymptomatic in respect to respiratory system, patients treated for SLE [3,10,11]. As it was mentioned before, the respiratory system is the area where autoantibodies and / or immune complexes may cause damage.…”

Section: Discussionmentioning

confidence: 99%

Selected growth factors and diffusing capacity of the lung for carbon monoxide in patients with systemic lupus erythematosus

et al. 2009

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The purpose of the study was to evaluate serum concentrations of selected growth factors and the diffusing capacity of the lung for carbon monoxide (DLCO) in 21 females treated for SLE. The control group consisted of 24 healthy women. Based on high-resolution computed tomography (HRCT), patients were allocated to a subgroup of 11 subjects (HRCT-negative) and a subgroup of 10 with pulmonary abnormalities (HRCT-positive). In HRCT-negative patients a significantly higher level of TNF-α as compared to the control was observed and positive correlation between TNF-α and bFGF was revealed in this subroup and in the total group of patients. DLCO was below the predicted value in 13 patients. No correlations between DLCO and growth factors concentrations were observed. DLCO reduction in asymptomatic, in respect to the respiratory system, SLE patients suggests a need for longterm monitoring of this parameter. The role of TNF-α in these patients requires further investigations.

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“…Pleurisy or pleural effusion is the most common pulmonary manifestations of SLE [2,3]. Interstitial lung disease (ILD), pulmonary embolism, pulmonary vasculitis and hypertension, bronchiolitis obliterans with or without organizing pneumonia (BOOP), shrinking lung syndrome, opportunistic pulmonary infections and toxicity due to immunosuppressive drugs are the other pulmonary complications of SLE [4,5]. ILD is not so common for SLE and even much rarer to be the initial manifestation of SLE.…”

Section: Introductionmentioning

confidence: 99%

Interstitial Lung Disease as Presenting Feature of SLE

Mondal¹,

Ete²,

Sinha³

et al. 2014

JCR

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Abstract:Interstitial lung disease (ILD) has been considered as an unusual pulmonary manifestation of systemic lupus erythematosus. Patients of ILD usually present with progressive dry cough and exertional dyspnea. ILD is usually seen in long standing SLE patients and follows a chronic course. ILD as the initial manifestation of SLE is very rare. Our middle aged female patient presented with pulmonary symptoms, renal impairment and arthralgia. She was finally diagnosed as having SLE by relevant autoantibody profile and renal biopsy along with HRCT proven ILD.

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A clinical study of pulmonary manifestations in systemic lupus erythematosus with special reference to CT findings

Cited by 18 publications

References 12 publications

Respiratory complications of the rheumatological diseases in childhood

Respiratory complications of the rheumatological diseases in childhood

Selected growth factors and diffusing capacity of the lung for carbon monoxide in patients with systemic lupus erythematosus

Interstitial Lung Disease as Presenting Feature of SLE

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