A clinical study of Punarnava Mandura in the management of Pandu Roga in old age (geriatric anemia)

Abstract

Background:The incidence of anemia rises with age. The consequences of anemia are many and serious, affecting not only individual's health, but also the development of societies and countries. Pandu Roga can be effectively compared with anemia on the ground of its similar signs and symptoms.Aim:To evaluate the Panduhara and Rasayana effect of Punarnava Mandura in the management of Pandu Roga in old age (geriatric anemia).Materials and Methods:The study was conducted in 50 clinically diagnosed patients of geriatric anemia. Patients were treated with Punarnava Mandura 2 tablets (250 mg each) twice in a day after lunch and dinner with Takra (butter milk) for 90 days. Among 50 registered patients, 40 patients had completed the treatment and 10 patients discontinued the treatment. Results were analyzed using Wilcoxon signed-rank test for subjective parameters and for assessment of objective parameters paired t-test was adopted.Results:At the end of study, drug has shown beneficial effect in patients of anemia by providing highly significant result in chief complaints, associated symptoms, Kshaya of Dhatu and Agni Bala, Deha Bala and Sattwa Bala. It has also improved quality-of-life (QOL) of the patients. Moderate and mild improvement was observed in 30 and 70% of the patients respectively.Conclusion:Punarnava Mandura may work as Rasayana in geriatric anemia by providing highly significant results on clinical features of Pandu Roga, Dehabala, Agni Bala and Sattwa Bala and by improving QOL. of patients of geriatric anemia.

Ayurvedic preparations for the management of Iron Deficiency Anemia: A systematic review

“…[ 15 ] However, Ayurveda has a different view on the role of Punarnavadi Mandura in controlling anemia which is primarily directed toward Agni (Digestive factors). [ 16 ] However, this concept is also indirectly related to the mechanism of absorption of iron in the gastrointestinal tract by the process of Deepana and Pachana . [ 16 17 ] This explanation of the action of Punarnavadi Mandura is not only applicable for the management of anemia among children but also in other age groups in which the mechanism remains the same.…”

A Review of Literature on Punarnavadi Mandura: An Ayurvedic Herbo-Mineral Preparation

“…Furthermore it was observed that this drug is effective in IDA among all age groups; pediatric, geriatrics and adult age groups. 6,12,13 Studies also reveal that this drug is well tolerated among the patients without any side effects and untoward effects compared to allopathic drug in one of the clinical trials. 12 One of the advantages of Ayurvedic preparations is that most of these drugs are administered with some vehicle which improves the efficacy of the parent drug and Punarnavadi Mandura is not an exception to this principle.…”

“…16 However, Ayurveda has a different view on the role of Punarnavadi Mandura in controlling anemia which is primarily directed towards Agni (Digestive fire). 6 But this concept is also indirectly related to the mechanism of absorption of iron in the gastro-intestinal tract by the process of Deepana and Pachana. 6,17 The study that focused on geriatric anemia has offered a probable explanation of the action of Punarnavadi Mandura among geriatric patients suffering from anemia.…”

“…6 But this concept is also indirectly related to the mechanism of absorption of iron in the gastro-intestinal tract by the process of Deepana and Pachana. 6,17 The study that focused on geriatric anemia has offered a probable explanation of the action of Punarnavadi Mandura among geriatric patients suffering from anemia. Triphala, Trikatu, Chitraka, Vidanga and Pippalimula have appetizer, digestive and carminative properties which improves digestive power and ultimately absorption of the drug.…”

“…Punarnavadi Mandura act as an anemia correcting agent possibly by its effect on Srotosa (micro channels) and Agni (digestive fire mechanism) and thereby enhancing digestive capacity owing to Deepana (appetizer), Pachana (digestive) properties. 6 In addition to anemia its role in other clinical conditions has been studied as well 7 Punarnavadi Mandura is being used for many other clinical conditions which include malabsorption syndrome, inflammation, splenic disease, intermittent fever, haemorrhoids, diseases of skin, and helminthiasis/ worm infestation. 5,8 Furthermore Punarnavadi Mandura is currently a part of national health programme in India.…”