A Clinical Test For Esophagitis

Non-Erosive Reflux Disease (NERD), Symptomatic and Asymptomatic Erosive Reflux Disease (ERD): From Hypersensitive to Hyposensitive Esophagus

“…In 1958, Bernstein and Baker described their classic test where they perfused the lower esophagus with dilute acid and evoked symptoms of ''heartburn'' in patients with GERD but not in healthy controls [4]. This test has been widely used over the years with modifications and has come to be generally called the Bernstein's test or ''acidperfusion'' test.…”

“…The acid perfusion test originally described by Bernstein has been used for a long time to assess esophageal sensitivity [4]. It has also been noted that volume reflux rather than just acid reflux can also generate symptoms.…”

Preoperative symptom evaluation and esophageal acid infusion predict response to laparoscopic Nissen fundoplication in gastroesophageal reflux patients who present with cough

“…In the Bernstein test [5], the patient receives either acid or saline infusion into the esophagus to determine whether the patient's symptoms can be triggered by acid. The technique we use is based on the original description by Bernstein and Baker but enhanced by``N of 1'' methodology reported by Guyatt et al [15].…”

High Prevalence of Heartburn and Low Acid Sensitivity in Patients with Idiopathic Achalasia

“…It is triggered by the presence of acid in the esophagus and can be reproduced by intraesophageal acid perfusion [1]. It has been previously reported that heartburn is a symptom frequently referred by patients with esophageal achalasia [2][3][4][5], although incidence of gastroesophageal reflux is expected to be low in these patients since the lower esophageal sphincter (LES), usually with a high baseline pressure, would maintain the defense barrier and thereby prevent the passage of gastric content to the esophagus.…”