A clinical trial of autologous adipose-derived regenerative cell transplantation for a postoperative enterocutaneous fistula

Abstract

Transplantation of autologous ADRCs is safe, feasible and advantageous, as it can secure a sufficient cell count without culture or multiple passages, and will likely be effective for a postoperative enterocutaneous fistula.

Concise Review: A Safety Assessment of Adipose-Derived Cell Therapy in Clinical Trials: A Systematic Review of Reported Adverse Events

“…Almost all organ system have been implicated in adipose‐derived cell therapy. The indication for treatment in the included studies was (in order count) soft tissue , gastrointestinal , musculoskeletal , rheumatological , ulcer/ischemic limb , urogenital , cardiac , neurological , immunological , pulmonary , and ophthalmological (Fig. A).…”

“…Almost all organ system have been implicated in adipose-derived cell therapy. The indication for treatment in the included studies was (in order count) soft tissue www.StemCellsTM.com [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35], gastrointestinal [8,[36][37][38][39][40][41][42][43][44][45][46][47][48], musculoskeletal [49][50][51][52][53][54][55][56][57][58], rheumatological [59][60][61][62][63], ulcer/ischemic limb [64][65][66][67], urogen...…”

“…Three of these studies were with ADRC and described proper blinding with the introduction of liposuction and subsequent sham ADRC injection [74][75][76]. Castillo-Cardiel et al 2015 [49] Chang et al 2013 [20] Garcia-Olmo et al 2009 [41] Gentile et al 2012 [23] Gentile et al 2014 [22] Guadalajara et al 2012 [42] Han et al 2009 [66] Henry et al 2016 [76] Herreros et al 2012 [43] Houtgraaf et al 2012 [74] Koh et al 2012 [54] Koh et al 2012 [34] Koh et al 2014 [51] Koh et al 2016 [52] Kølle et al 2013 [24] Li et al 2013 [25] Marino et al 2013 [67] Onesti et al 2016 [60] Pan es et al 2016 [44] Peltoniemi et al 2013 [28] Perin et al 2014 [75] Sterodimas et al 2011 [29] Tanikawa et al 2013 [30]…”

Intra‐articular autologous uncultured adipose‐derived stromal cell transplantation inhibited the progression of cartilage degeneration

“…UADSCs are the nonbuoyant cellular fraction containing several types of stem and regenerative cells, including ADSCs, vessel‐forming cells, such as endothelial and smooth muscle cells, and preadipocytes . In the previous clinical study, UADSC has been reported to be safe, feasible and advantageous, as it can secure a sufficient cell count without culture or multiple passages, compared with ADSC …”

“…18 In the previous clinical study, UADSC has been reported to be safe, feasible and advantageous, as it can secure a sufficient cell count without culture or multiple passages, compared with ADSC. 19 There is insufficient evidence supporting the effectiveness of UADSC for OA despite the general perception regarding their potential for becoming an alternative cell-based treatment modality. Recent studies have reported that the paracrine effect of ADSCs on chondrocytes is the key contributor for the suppressive effects of OA development in a rabbit model.…”