“…Additional features may include eczematous changes, vesicles, or targetoid lesions d PUPPP predominantly involves the trunk (abdomen) and proximal extremities d Spontaneous complete resolution occurs within weeks d A histologic examination reveals a nonspecific perivascular lymphohistiocytic infiltrate with some edema and eosinophils in the dermis; direct and indirect immunofluorescence studies are routinely negative PUPPP, also known as polymorphic eruption of pregnancy, is one of the most commonly diagnosed pruritic dermatoses of pregnancy, but it has a J AM ACAD DERMATOL VOLUME 62,NUMBER 4 confusing nomenclature because of the diversity of its cutaneous features. 57,58 The disease usually affects women during their first pregnancy, and the skin lesions classically appear in the third trimester (mean onset in the 35th week [range, [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42]), and in extremely rare cases it first appears postpartum or earlier on in the pregnancy. 57,58 The etiology of PUPPP is still unknown; hormonal changes, connective tissue damage, and immunologic mechanisms are likely involved.…”