A clinico-pathological and follow up study of 10 cases of essential type II cryoglobulinaemic neuropathy.

Cavaletti, Guido; Petruccioli, M G; Crespi, Valentino; Pioltelli, Pietro; Marmiroli, P; Tredici, G

doi:10.1136/jnnp.53.10.886

Cited by 35 publications

(21 citation statements)

References 15 publications

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“…3,4 In a 1-year follow-up study of 10 patients with cryoglobulinemic neuropathy, Cavaletti et al reported that no further peripheral nerve damage occurred. 3 In a prospective 6-year follow-up study of 9 consecutive MC patients treated with cyclophosphamide or prednisone, or both, Crespi et al reported a lack of neuropathy progression and concluded that the stability was related to good control of MC. 4 In our patients, MC did not progress during the period of follow-up.…”

Section: Discussionmentioning

confidence: 97%

“…5,7 The prevalence of peripheral neuropathy was recently reported to be 50 -86% in large series of MC patients, 1,5 but there are few published studies regarding evolution and long-term prognosis of neuropathy in MC patients. 3,4 We report a retrospective, cross-sectional study on a series of MC patients, with or without neuropathy at hospitalization, who were followed-up clinically and electrophysiologically to define the evolution and course of nerve involvement with time. …”

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confidence: 99%

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Peripheral neuropathy in hepatitis‐related mixed cryoglobulinemia: Electrophysiologic follow‐up study

et al. 2004

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A retrospective study was performed on 27 patients with hepatitis C (HCV)-related mixed cryoglobulinemia (purpura, arthralgia, hepatitis, glomerulonephritis, peripheral neuropathy) to assess peripheral nerve involvement during follow-up of up to 8 years. All patients had the same degree of organ/system involvement initially and were clinically evaluated at least annually. All 27 patients received steroids; 15 also received recombinant interferon-alpha 2b (rIFN-alpha 2b). At first examination, neurological signs and electrodiagnostic findings consistent with peripheral neuropathy were found in 20 (74%) and in 24 (88.8%) patients, respectively. Neurological evaluation and electrodiagnostic data at 3 and 8 years revealed worsening of neuropathy, whereas the other manifestations of mixed cryoglobulinemia (MC) were stable. At the last examination, clinical and electrodiagnostic signs of neuropathy were found in 25 patients (92.5%), occurring in 1 of 3 patients with normal initial findings, and worsened in 8. A more severe neuropathy was observed in 3 (25%) of the patients treated with prednisone alone and in 6 (40%) of the patients additionally treated with rIFN-alpha 2b. Our data confirm that in patients with HCV-related MC, peripheral nerve involvement is frequent, is progressive, and does not seem to benefit by addition of rIFN-alpha 2b to steroid treatment.

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Section: Discussionmentioning

confidence: 97%

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confidence: 99%

Peripheral neuropathy in hepatitis‐related mixed cryoglobulinemia: Electrophysiologic follow‐up study

et al. 2004

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“…53 In the setting of a peripheral neuropathy, a sural nerve biopsy reveals endoneural vasculitis with vessel wall destruction and with patchy, focal loss of myelinated fibers with axonal degeneneration. [54][55][56] Intravascular deposition of cryoglobulins in the vaso nervorum microcirculation without frank vasculitis can be seen in milder distal neuropathies. 39 When kidneys are involved, a biopsy typically shows membranoproliferative glomerulonephritis with deposition of immunoglobulin and complements in the subendothelium.…”

Section: Pathologymentioning

confidence: 99%

Cold Hard Facts of Cryoglobulinemia

Ghetie¹,

Mehraban²,

Sibley³

2015

Rheumatic Disease Clinics of North America

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“…Sensory asymmetric neuropathy has been seen in cryoglobulinaemia type II,20 and neuropathy may precede skin manifestations of cryoglobulinaemia. Sural nerve biopsies show features of axonal degeneration and abnormalities of endoneurial microvessels ranging from overt vasculitis to thickening of the vessel wall and redundant basal lamina formation.20 21 Recently it has been suggested that precipitation of cryoglobulins within the vascular lumen may cause occlusive microangiopathy. 22 No evidence in support of cryoglobulinaemia was found.…”

Section: Dr Wokkementioning

confidence: 99%