A clinico‐pathological approach to the classification of human demodicosis

Akilov, Oleg E.; Butov, Yuri S.; Mumcuoglu, Kosta Y.

doi:10.1111/j.1610-0387.2005.05725.x

Cited by 46 publications

(13 citation statements)

References 26 publications

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“…They also found higher prevalences of D. folliculorum infestation in the forehead and nose region than on the cheeks and chin region. This finding concurs with those of Akilov et al24, who concluded D. folliculorum is more likely to cause demodicosis in the facial T-zone. These results indicated that the development of sebum secretion and the dilation of follicle in the T-zone are attributable to the proliferation of D. folliculorum , and that this increases the detection rate of SSSB.…”

Section: Discussionsupporting

confidence: 93%

“…The first is that pityriasis folliculorum is usually caused by the more superficially living D. folliculorum , whereas rosacea type is commonly associated with the deep living D. brevis 24. The second is that measurements are usually performed using severe lesions.…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis of demodicosis was made when compatible clinical manifestations of demodicosis was combined with a high Dd (>5D/cm 2 ) by SSSB620 or DME192324.…”

Section: Methodsmentioning

confidence: 99%

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DemodexMite Density Determinations by Standardized Skin Surface Biopsy and Direct Microscopic Examination and Their Relations with Clinical Types and Distribution Patterns

Yun

Yun²,

Baek

et al. 2017

Ann Dermatol

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BackgroundDemodicosis is a parasitic skin disease caused by Demodex mites, and the determination of mite density per square centimeter is important to diagnose demodicosis. Standardized skin surface biopsy (SSSB) and direct microscopic examination (DME) are commonly used to determine Demodex mites density (Dd). However, no study has previously compared these two methods with respect to clinical types and distribution patterns of demodicosis.ObjectiveThe aim of this study was to compare the value of SSSB and DME findings in reference to the clinical types and distribution patterns of demodicosis.MethodsThe medical records of 35 patients diagnosed with demodicosis between December 2011 and June 2015 were retrospectively reviewed. Demodicosis was classified according to four clinical types (pityriasis folliculorum, rosacea type, acne type, and perioral type) and three distribution patterns (diffuse pattern, U-zone pattern, and T-zone pattern). Two samples, one for SSSB and one for DME, were obtained from a lesion of each patient.ResultsIn all patients, mean Dd and the proportion with a high Dd (>5D/cm2) by DME (14.5±3.3, 80.0%, respectively) were higher than by SSSB (5.5±1.3, 37.1%, respectively; p<0.01, p=0.02, respectively). In terms of clinical types, for rosacea type, mean Dd and proportion with a high Dd by DME (12.4±3.5, 84.6%, respectively) were significantly greater than those determined by SSSB (3.6±1.2, 23.1%; p=0.04, p=0.04, respectively). In terms of distribution pattern, for the diffuse pattern, mean Dd and the proportion with a high Dd by DME (17.5±3.7, 100%, respectively) were significantly higher than those determined by SSSB (6.0±2.7, 26.7%; p<0.01, p<0.01, respectively).ConclusionThe results of our study revealed that DME is a more sensitive method for detecting Demodex than SSSB, especially in patients with diffuse pattern and suspected rosacea type. Further research is needed to confirm this finding.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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DemodexMite Density Determinations by Standardized Skin Surface Biopsy and Direct Microscopic Examination and Their Relations with Clinical Types and Distribution Patterns

Yun

Yun²,

Baek

et al. 2017

Ann Dermatol

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“…Deeper and larger [102,105,113] Pruritus Usually considered more frequent in demodicosis [70,72,74,79,241,242,99] Evolution over time The 2 forms may occur successively in the same patient [10] Often after pityriasis folliculorum More often after ETR than the reverse [8,57,136] Treatment Acaricide Anti-inflammatory, acaricide of benzyl benzoate (with crotamiton) on Demodex density and on clinical symptoms in a real-life study [159,160]. In our practice, we successfully used benzyl benzoate (with crotamiton) cream for more than 20 years; however, the development of ivermectin has provided an effective alternative [172,223,224] with better tolerance and this is now our treatment of choice.…”

Section: More Superficial and Smallermentioning

confidence: 99%

The Pathogenic Role of Demodex Mites in Rosacea: A Potential Therapeutic Target Already in Erythematotelangiectatic Rosacea?

Forton¹

2020

Dermatol Ther (Heidelb)

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Rosacea is an inflammatory continuum, with all characteristics being already present from the onset of the disease, even if not clinically visible. Demodex proliferation also appears to be a continuum process in rosacea, and high Demodex density is beginning to be accepted as an important trigger of the inflammatory cascade and as a marker of rosacea: moreover, papulopustules of rosacea can be treated using acaricides. Immunological studies are providing new hypotheses according to which Demodex may induce tolerogenic dendritic cells and collaborate with VEGF to induce T cell exhaustion favoring its own proliferation. This proliferation may not be clinically visible initially. The interactions among VEGF, Demodex, and immunity need to be explored, and the nosology of rosacea definitions adapted accordingly. The effectiveness of treating any patient who only has visible vascular symptoms with an acaricidal cream needs to be confirmed in prospective controlled clinical trials with long-term follow-up, but it is already important to detect patients with pityriasis folliculorum among those with only vascular symptoms of rosacea in order to treat at least these patients with an acaricidal cream. DIGITAL FEATURES This article is published with digital features to facilitate understanding of the article. You can access the digital features on the article's associated Figshare page. To view digital features for this article go to

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“…Signs and symptoms of the disease are present (erythema, pruritus, etc. ), this clinic course is thought to be induced by D. brevis [19].…”

mentioning

confidence: 99%

Histopathologic Evaluation of Acneiform Eruptions: Practical Algorithmic Proposal for Acne Lesions

Alper¹,

Khurami²

2017

Acne and Acneiform Eruptions

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Acneiform lesions are encountered in different chapters in various dermatology and dermatopathology textbooks. The most common titles used for these disorders are diseases of the hair, diseases of cutaneous appendages, folliculitis, acne, and inflammatory lesions of dermis and epidermis. In this chapter, first of all we will discuss folliculitis, and then acne vulgaris that is a kind of folliculitis will be described. After acne vulgaris, other acneiform eruptions and demodicosis will be studied. At the end, simple algorithmic schemes by assembling clinical, pathological, and microbiological data will be shared.

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A clinico‐pathological approach to the classification of human demodicosis

Cited by 46 publications

References 26 publications

DemodexMite Density Determinations by Standardized Skin Surface Biopsy and Direct Microscopic Examination and Their Relations with Clinical Types and Distribution Patterns

DemodexMite Density Determinations by Standardized Skin Surface Biopsy and Direct Microscopic Examination and Their Relations with Clinical Types and Distribution Patterns

The Pathogenic Role of Demodex Mites in Rosacea: A Potential Therapeutic Target Already in Erythematotelangiectatic Rosacea?

Histopathologic Evaluation of Acneiform Eruptions: Practical Algorithmic Proposal for Acne Lesions

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