A Clinico-Pathological Correlation Study of Leprosy in a Tertiary Care Teaching Institute in Northwest Punjab, India

Badhan, Raveneet; Kundal, Ramesh Kumar; Raj, Rakesh Tilak; Bahl, Rakesh Kumar; Bal, Manjeet Singh

doi:10.12691/ajmsm-2-5-4

Cited by 8 publications

(13 citation statements)

References 12 publications

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“…In the present study, majority of the patients were of PB type (32 cases; 51.61%) and the rest were of MB type (30 cases; 48.38%) on tissue sections. Similar observations were made by Badhan R et al [7] while study done by Giridhar et al 11 showed majority of patients were of MB type (55 cases; 56.13%). The bacterial index on SSS was calculated in 52 cases, out of which 17 cases (32.69%) were positive for acid fast bacilli [ Table 4].…”

Section: Discussionsupporting

confidence: 85%

“…Histopathologically, the most commonly encountered type of leprosy was IL (21 cases; 33.90%), followed by LL (16 cases; 25.80%) and the least common type was the BB (1 cases; 1.61%).Similar observations were made by Singh J et al [5] and Arunagirinathan M et al, [6] while BT was the most common type in the study done by Badhan R et al [7] and Rizvi A A et al [8] The high percentage of IL noted histopathologically in our study could have been due to immunological differences in host responses, duration of the lesion, nature and depth of the biopsy, quality of the sections and number of acid fast stained sections examined. Selection of the site of biopsy also plays an important role since clinically different lesion biopsied from same patient can show different type of histopathology.…”

Section: Discussionsupporting

confidence: 80%

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Histomorphological Study of Leprosy with Clinical Correlation in Kumaon Region

Yadav

Kumar

Joshi

et al. 2019

ijmsci

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Background: Leprosy is a leading cause of permanent physical disability. Approx 60% of global burden of leprosy is represented by India. Histopathological examination is still considered gold standard for accurate categorization of leprosy so that timely treatment can be started. Objectives: To categorize and correlate types of leprosy clinically and histomorphologically in Kumaon region. Methods: The present cross-sectional study of 62 cases was conducted in the Department of Pathology & Skin and V.D in a tertiary care centre of Kumaon region from August 2016 to April 2018. The cases were clinically examined and categorized according to Ridley-Jopling classification. Skin Biopsy and Slit-Skin Smear (SSS) were taken for accurate histomorphogical categorization of leprosy and assessment of bacterial index, followed by clinico-histomorphological correlation. Statistical analysis was done in term of chi-square test. Kappa test was used as agreement test for clinical versus histological classification of different type of leprosy. Results: A total of 62 clinically diagnosed leprosy cases evaluated histopathologically. Clinically, lepromatous leprosy (LL) was the most common type of leprosy (38.70%), followed by borderline tuberculoid (30.64%). On histopathological examination, indeterminate leprosy (IL) (21 cases; 33.90%) was the most common followed by lepromatous leprosy (16 cases; 25.80%). Overall clinico-histopathological correlation was seen in 36 cases (58. 06%) with maximum correlation seen in indeterminate leprosy (100%) and tuberculoid leprosy (TT) (100%). Conclusion: This study concludes that correlation of clinical and histopathological features along with bacterial index is more useful for accurate typing of leprosy than considering any of the single parameter alone so that early and appropriate treatment could be started.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 80%

Histomorphological Study of Leprosy with Clinical Correlation in Kumaon Region

Yadav

Kumar

Joshi

et al. 2019

ijmsci

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“…Most of the studies showed the peak incidence in 21 to 30 years and 21 to 40 years. Hence the minimum number of cases observed in the present study was in the 1st decade and it is in full agreement with Fauziahkurdi et al, 15 Tekwani D and Joshi R et al 11 In the present study our observation for distribution of leprosy cases in both sexes is in concordance with other studies like, Fakeha Firdous DP et al, 16 Kumar A et al, 17 Badhan R et al, 18 Mehta. B et al, 19 Premanshu Bhushan et al, 20 Veena Shivamurthy et al 21 In the present study our observations shows that 57/80 i.e.…”

Section: Subject Characteristicssupporting

confidence: 93%

Study of Morphological Patterns of Leprosy in a Rural Setup

Gulhane¹,

Hiwale²,

Bhake³

et al. 2020

jemds

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BACKGROUND Leprosy is a chronic disease of ancient world and is still afflicting patients in many parts of world mainly Asia and Africa. Leprosy is one of the most dreaded diseases of humankind. We wanted to study the various microscopic patterns and subtypes of Leprosy. We also wanted to study the Bacterial Index in the region of Sawangi, Meghe. METHODS 80 skin biopsies after adequate fixation in 10% of formalin, were routinely processed and were stained with H and E, Fite-Faraco stain and Modified Rapid Acid-Fast Bacilli (MRAFB staining) method, were studied microscopically and bacterial index was calculated. RESULTS A total of 80 skin biopsies were obtained from patients of department of dermatology over a period of two years from 2017 to 2019. Among them Lepromatous leprosy were 43 cases, Tuberculoid leprosy were 23 cases, Borderline lepromatous leprosy were 09 cases, Borderline tuberculoid leprosy were 03 cases, histoid leprosy were 01 case and ENL were 01 case. With an age range of 6-85 years, majority were in 31-40 years of age group, with male to female ratio of 2.47:1. LL was the most common type of leprosy (53.75%). CONCLUSIONS Accurate diagnosis of leprosy purely on clinical grounds is extremely difficult. Hence, there can be false positive and false negative diagnosis. Since histopathology is confirmatory, with application of Fite-Faraco and MRAFB staining it can also evaluate the bacterial load. Hence in all suspected cases of leprosy, histopathology along with Fite-Faraco and MRAFB staining should compulsorily be done.

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“…Histological diagnosis was established in 92.3 % cases in the present study by two pathologists, which is similar to other studies in literature. [17] The overall clinicopathological correlation in our study was 66.7% i.e. there was complete agreement between clinical and histopathological diagnosis in 40 cases.…”

Section: Discussionsupporting

confidence: 64%

Clinical and histological profile of leprosy patients at rural based tertiary care centre in post elimination era

Bindal¹,

Kalra²,

Garg³

et al. 2018

APALM

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Background: Despite India having achieved the national leprosy elimination goal of prevalence rate less than one case per 10000, the disease is still prevalent. Its diverse presentation depending on immune status of host warrants a clinico-histological correlation for diagnosis and start of proper therapy. Aim:The present study was done with the aim to describe the spectrum of clinical and histological profile of leprosy patients especially in doubtful and difficult cases especially where the clinical diagnosis is not sufficient and, then, to correlate clinical and histological profile.Methods: This study is a hospital based prospective study conducted on sixty newly diagnosed cases of leprosy. Skin biopsy was taken in each case and processed routinely. All the cases were stained with hematoxylin and eosin and modified Ziehl-Neelsen stain. Ridley-Jopling classification was used for diagnosis and typing of cases. Results:In the present study consisting of 60 newly diagnosed leprosy patients, majority of the cases i.e. 18 (30%) were in age group of 21-30 years with male: female ratio of 1.6:1. The most common type of skin lesion was plaque (50%), followed by hypo-pigmented macule (33.3%). The clinico-pathological concordance was maximum in Tuberculoid (TT) (100%) followed by Lepromatous (LL) (80%), Borderline lepromatous (BL) (72.7%), Borderline tuberculoid (BT) (50%) and Mid-borderline (BB) (33.3%). Conclusion:The overall clinicopathological concordance in present study is good (66.7%). Thus, the correlation of clinical and histological features along with bacillary index is far more useful for accurate typing and therapy in leprosy patients.

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A Clinico-Pathological Correlation Study of Leprosy in a Tertiary Care Teaching Institute in Northwest Punjab, India

Cited by 8 publications

References 12 publications

Histomorphological Study of Leprosy with Clinical Correlation in Kumaon Region

Histomorphological Study of Leprosy with Clinical Correlation in Kumaon Region

Study of Morphological Patterns of Leprosy in a Rural Setup

Clinical and histological profile of leprosy patients at rural based tertiary care centre in post elimination era

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