A Clinicopathologic Analysis of 109 Cases with Emphasis on Distinguishing Pathologic Features, Site of Origin, Prognosis, and Relationship to “Pseudomyxoma Peritonei”

Mucinous epithelial neoplasms of the appendix and pseudomyxoma peritonei

“…They also described an intermediate category for tumors that were mostly DPAM but with focal areas of welldifferentiated adenocarcinoma. 65 Initially, these patients appeared to have an intermediate prognosis, but additional follow-up showed that they behaved like PMCA. 76 In contrast, a study of 101 patients with PMP by Bradley et al 77 found that patients with DPAM and intermediate grade peritoneal mucinous tumors had similar outcome, and that they fared better than those with high-grade peritoneal tumors.…”

“…Other organs may be affected such as small or large bowel, liver, or ovary. 10,65 Non-mucinous appendiceal adenocarcinomas show a range of morphologic features of the invasive component. The tumors may resemble colonic adenocarcinomas with malignant glands lined by columnar cells with central dirty necrosis (Figure 11).…”

Clinicopathologic and molecular analysis of disseminated appendiceal mucinous neoplasms: identification of factors predicting survival and proposed criteria for a three-tiered assessment of tumor grade

“…[1][2][3][4][5] Several studies have demonstrated that disseminated appendiceal mucinous neoplasms exhibit a wide spectrum of clinical behavior, ranging from neoplasms which are relatively slow-growing but with considerable risk for recurrence and eventual death and those neoplasms that are highly aggressive with increased likelihood of early death. [6][7][8][9][10][11] There are multiple clinical factors that influence survival in patients with disseminated mucinous appendiceal neoplasms, but pathologic grade has repeatedly been shown to be an independent prognostic factor. [6][7][8][9]11,12 Proposed terminology for lowgrade tumors has included disseminated peritoneal adenomucinosis, 11 low-grade mucinous carcinoma peritonei, 7 low-grade mucinous neoplasm, 8,9 and well-differentiated mucinous adenocarcinoma.…”

Application of Advanced Multimodality Care to Pseudomyxoma Peritonei Patient: Report of First Patient Treated at a Tertiary Center

“…Other sites include ovary and pancreas. Most cases of cystic ovarian mucinous tumors associated with pseudomyxoma peritonei are associated with metastases from an appendiceal tumor [6]. In women, cells become entrapped within the corpus hemorrhagicum and consequently, it is the detection of an ovarian cyst that often brings about the diagnosis of pseudomyxoma peritonei.…”

“…PMP syndrome has been histologically classified into three categories: disseminated peritoneal adenomucinosis (DPAM), peritoneal mucinous carcinomatosis (PMCA), and PMCA with intermediate or discordant features (PMCA-I/D) which predominantly have features of DPAM but also have focal areas of carcinoma [6]. There is a significant survival difference between DPAM and the intermediate type or mucinous adenocarcinomas and thus for the greatest benefit of treatment the noninvasive histology is the most important thing [4].…”