A Clinicopathologic Description of Myocarditis

Lieberman, Eric B.; Herskowitz, Ahvie; Rose, Noel R.; Baughman, Kenneth L.

doi:10.1006/clin.1993.1117

Cited by 112 publications

(113 citation statements)

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“…Acute myocarditis is able to be mainly divided into two disease conditions on a basis of clinicopathologic profiles, namely fulminant and non-fulminant myocarditis (16)(17). Briefly, fulminant myocarditis is represented by the distinct onset of cardiac symptoms within 2 weeks following flu-like symptoms accompanied by histologically proven active myocarditis according to Dallas criteria and severe circulatory failure requiring high-dose intravenous catecholamines use (>5.0 γ) or mechanical circulatory assist devise, while non-fulminant myocarditis is by the indistinct onset of cardiac symptoms without those.…”

Section: Cardiac Inflammatory Diseases; Acute Myocarditismentioning

confidence: 99%

“…However, more than 80% of fulminant cases recover completely to an uncomplicated status, with cessation of myocardial inflammation and a generally favorable outcome, provided they are able to overcome poor cardiac condition successfully during acute phase (18). On the other hand, nonfulminant myocarditis without severe circulatory failure is likely to develop to chronic HF derived from dilated cardiomyopathy at chronic phase (16)(17). Therefore, simple biomarkers to predict a requirement of mechanical assist devise use, outcome following its use, or the development to cardiomyopathy in patients with acute myocarditis have been sought.…”

Section: Cardiac Inflammatory Diseases; Acute Myocarditismentioning

confidence: 99%

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Biomarker for Cardiomyopathy-B-Type Natriuretic Peptide

Nishii¹,

Izumi²

2012

Cardiomyopathies - From Basic Research to Clinical Management

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Cardiomyopathy means "heart (cardio) muscle (myo) disease (pathy)". Currently, cardiomyopathies are defined as myocardial disorders in which the heart muscle is structurally and/or functionally abnormal in the absence of a coronary artery disease, hypertension, valvular heart disease or congenital heart disease sufficient to cause the observed myocardial abnormalities. This book provides a comprehensive, state-of-theart review of the current knowledge of cardiomyopathies. Instead of following the classic interdisciplinary division, the entire cardiovascular system is presented as a functional unity, and the contributors explore pathophysiological mechanisms from different perspectives, including genetics, molecular biology, electrophysiology, invasive and non-invasive cardiology, imaging methods and surgery. In order to provide a balanced medical view, this book was edited by a clinical cardiologist.

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Section: Cardiac Inflammatory Diseases; Acute Myocarditismentioning

confidence: 99%

Section: Cardiac Inflammatory Diseases; Acute Myocarditismentioning

confidence: 99%

Biomarker for Cardiomyopathy-B-Type Natriuretic Peptide

Nishii¹,

Izumi²

2012

Cardiomyopathies - From Basic Research to Clinical Management

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“…Acute myocarditis typically presents with a less distinct prodromal illness period, in contrast with fulminant myocarditis, which has a more defined viral prodrome and associated with more severe cardiovascular compromise. Acute myocarditis is also more likely to present in those patients with established ventricular dysfunction, with the potential to progress to dilated cardiomyopathy [2].…”

Section: Introductionmentioning

confidence: 99%

Acute focal Myocarditis with Preserved Ventricular Function Masquerading as Acute ST-elevation Inferior Wall Myocardial Infarction

Shehadeh¹

2015

JCCR

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A 19 year old male with no significant past medical history, presents to the emergency room with sudden onset, severe, retrosternal, chest pain while in school. The patient stated the pain was constant, 6/10 severity, lasting 6 hours prior to presentation, no radiation or alleviating or aggravating factors, and associated with initial shortness of breath at rest and diaphoresis. The patient has no history of any prior episodes of similar presentation. The patient has no known drug allergies, and was not taking any medications. The patient's family history is significant for his mother having a history of Sjogren's and surviving an acute myocardial infarction with cardiac arrest at age 42, who received a drug-eluting stent after the MI. The patient denies any smoking, alcohol, drug use and reports a noncontributory sexual history.On admission, the patient was afebrile, with a blood pressure of 118/72, pulse rate of 78 beats per minute, respiratory rate of 16 breaths per minute, and oxygen saturation of 98% on room air. The physical exam indicated his jugular venous pressure was within normal limits. His heart rate and rhythm were regular, with no murmurs, rubs, or gallops appreciated, and normal S1 and S2 heart sounds. In addition, his lungs were clear to auscultation bilaterally, and the exam of his extremities revealed no appreciable peripheral edema. Chest X-ray revealed a normalsized cardiac border with no infiltrates or effusions.A diagnosis of acute inferior wall ST-elevation myocardial infarction was initially considered due to the ECG findings, which showed upwardly concave ST elevations in leads II, III, and aVF, subtle PR depressions in leads II, III, and aVF, non specific ST elevations in V3-V5, T wave inversions in aVR, aVL, V1, and V2, as well as reciprocal ST depression in aVR and V (Figure 1a).At this time, his initial cardiac enzymes revealed peak values of a troponin I 4.56 ng/ml (upper limit of normal =0.06 ng/ ml), myocardial band fraction was 36 ng/ml (upper limit of normal=6.3 ng/ml), and creatinine kinase 494 IU/L (upper limit of normal=195 IU/L), with a normal basic metabolic profile and complete blood count. After the patient was given nitroglycerin without resolution of his chest pain, he was started on IV heparin, aspirin, clopidogrel, statin, beta-blockers, ace-inhibitors, and low dose intravenous morphine in the emergency room, and reported improvement of the chest pain. Echocardiography performed during the initial admission revealed an ejection fraction of 60% with no regional wall motion abnormalities, no valvular dysfunction, no pericardial effusion, and no diastolic dysfunction. Due to the patient's history of present illness, family AbstractMyocarditis is a pathological inflammatory condition which can result in significant damage to the myocardium and more specifically the myocytes. Acute myocarditis can present similarly to myocardial infarction, and can rise to the top of the differential diagnosis when chest pain, cardiac enzymes, and ECG that suggest myocardial infarction a...

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“…As well, echocardiography did not reveal any regional wall motion abnormalities, which are generally helpful in differentiating cardiac diseases and defi ning the nature of the myocardial dysfunction. Myocarditis is typically characterized by a decreased left ventricular ejection fraction and hypokinesia of the ventricular walls, and may be associated with pericardial effusion and valvular regurgitation 11 . Regarding other diagnoses, we excluded acute viral myocarditis, as the serology results were negative for commonly implicated viruses.…”

mentioning

confidence: 99%

An unusual case of heart failure due to Plasmodium vivax infection with a favorable outcome

Dev

Gadpayle

Sankar

et al. 2014

Rev. Soc. Bras. Med. Trop.

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Although malaria is one of the oldest types of parasitic infection, we have recently witnessed substantial changes in the outcome of malarial infections. Severe Plasmodium vivax infections have recently become more frequent, and are occasionally associated with fatal outcomes. Cardiac arrhythmia and myocardial failure have also been reported, typically in association with Plasmodium falciparum infections. We report a case of myocarditis and heart failure, due to Plasmodium vivax infection, along with the favorable outcome.

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A Clinicopathologic Description of Myocarditis

Cited by 112 publications

References 0 publications

Biomarker for Cardiomyopathy-B-Type Natriuretic Peptide

Biomarker for Cardiomyopathy-B-Type Natriuretic Peptide

Acute focal Myocarditis with Preserved Ventricular Function Masquerading as Acute ST-elevation Inferior Wall Myocardial Infarction

An unusual case of heart failure due to Plasmodium vivax infection with a favorable outcome

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