A clinicopathologic review of oesophageal carcinoma in Lagos

Abdulkareem, F B; Onyekwere, Charles; Awolola, N A; Banjo, A A F

doi:10.4314/nqjhm.v18i2.44979

Cited by 6 publications

(8 citation statements)

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“…This report is in keeping with the most of surveys conducted on patients with oesophageal cancers in our region and beyond [2,3] . The vast majority of reports of similar varicoid lesions also are of the squamous type [1,5,7] .…”

Section: Discussionsupporting

confidence: 88%

“…At initial presentation, the two most common symptoms of oesophageal cancer in our region are dysphagia and progressive weight loss, as reported in many other parts of the world [2,3] . Dysphagia usually results from advanced lesions that have led to substantial compromise in the caliber of the oesophageal lumen [3,4] .…”

Section: Discussionmentioning

confidence: 53%

“…This is, however, easier said than carried out in resource-limited settings in light of the many challenges associated with endoscopy practice [2] , but it is certainly not impossible, as this case report opines.…”

Section: Resultsmentioning

confidence: 91%

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An uncommon pattern of oesophageal cancer presentation

Oluyemi

Adeyomoye²

2015

CRIM

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Introduction: Common morphological patterns of oesophageal cancer presentation include stricture formation, mucosal ulceration, or the presence of exophytic fungating masses, nodules, and fistulae. The varicoid type is, however, rare. Case presentation:The index case is a 74-year-old lady who had no classical complaints that are often associated with oesophageal cancer and had the varicoid type discovered on endoscopy screening. Conclusion:The purpose of this case report is to document such a pattern for the first time in the authors' environment and to highlight the utility of endoscopy in early detection of malignancy when commonly identified signs and symptoms are absent.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 53%

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An uncommon pattern of oesophageal cancer presentation

Oluyemi

Adeyomoye²

2015

CRIM

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“…Of the 48 studies on epidemiology of EC, 13 (27.1%) were conducted in South Africa[23-35], 8 (16.7%) in Kenya[36-43], 4 (8.3%) in Uganda[44-47], 3 each in Zimbabwe (6.3%)[48-50], Malawi (6.3%)[51-53], Sudan (6.3%)[54-56] and Nigeria (6.3%)[57-59], 2 each in Tanzania (4.2%)[60,61] and Zambia (4.2%)[62,63], 1 each in Egypt (2.1%)[64], Mozambique (2.1%)[65], Senegal (2.1%)[66] and Botswana (2.1%)[67], and 3 (6.3%) studies were multi-country[22,68,69].…”

Section: Resultsmentioning

confidence: 99%

Systematic review of esophageal cancer in Africa: Epidemiology, risk factors, management and outcomes

Asombang¹,

Chishinga²,

Nkhoma³

et al. 2019

WJG

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BACKGROUND Esophageal cancer (EC) is associated with a poor prognosis, particularly so in Africa where an alarmingly high mortality to incidence ratio prevails for this disease. AIM To provide further understanding of EC in the context of the unique cultural and genetic diversity, and socio-economic challenges faced on the African continent. METHODS We performed a systematic review of studies from Africa to obtain data on epidemiology, risk factors, management and outcomes of EC. A non-systematic review was used to obtain incidence data from the International Agency for Research on Cancer, and the Cancer in Sub-Saharan reports. We searched EMBASE, PubMed, Web of Science, and Cochrane Central from inception to March 2019 and reviewed the list of articles retrieved. Random effects meta-analyses were used to assess heterogeneity between studies and to obtain odds ratio (OR) of the associations between EC and risk factors; and incidence rate ratios for EC between sexes with their respective 95% confidence intervals (CI). RESULTS The incidence of EC is higher in males than females, except in North Africa where it is similar for both sexes. The highest age-standardized rate is from Malawi (30.3 and 19.4 cases/year/100000 population for males and females, respectively) followed by Kenya (28.7 cases/year/100000 population for both sexes). The incidence of EC rises sharply after the age of 40 years and reaches a peak at 75 years old. Meta-analysis shows a strong association with tobacco (OR 3.15, 95%CI: 2.83-3.50). There was significant heterogeneity between studies on alcohol consumption (OR 2.28, 95%CI: 1.94-2.65) and on low socioeconomic status (OR 139, 95%CI: 1.25-1.54) as risk factors, but these could also contribute to increasing the incidence of EC. The best treatment outcomes were with esophagectomy with survival rates of 76.6% at 3 years, and chemo-radiotherapy with an overall combined survival time of 267.50 d. CONCLUSION Africa has high incidence and mortality rates of EC, with preventable and non-modifiable risk factors. Men in this setting are at increased risk due to their higher prevalence of tobacco and alcohol consumption. Management requires a multidisciplinary approach, and survival is significantly improved in the setting of esophagectomy and chemoradiation therapy.

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“…Les plus hautes incidences sont retrouvées en Asie, de la région allant du Nord de la Chine au littoral iranien de la mer Caspienne. C'est une pathologie globalement rare en Afrique, sauf dans la région du Transkei qui semble être son épicentre sur le continent [4][5][6][7]. Le carcinome épidermoïde est la forme histologique prédominante à travers le monde.…”

Section: Introductionunclassified

Cancer de l’œsophage au Sénégal: revue d’une série de 72 cas

Diop

Ndoye

Ndiaye

et al. 2009

J Afr Hepato Gastroenterol

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But : Le cancer de l'oesophage, du fait de son mauvais pronostic, est une tumeur digestive redoutée. Le but de ce travail était d'apprécier les caractéristiques épidé-miologiques, anatomocliniques et le devenir d'une série de patients. Malades et méthodes : Il s'agissait d'une analyse rétrospec-tive de 72 dossiers de patients pris en charge par la même équipe, suivis de janvier 2004 à décembre 2007. Résultats : Le carcinome épidermoïde représentait 94,4 % des cancers de l'oesophage durant cette période. L'âge moyen des patients était de 48 ans avec des extrêmes de 16 et 86 ans. Le diagnostic était tardif avec un délai moyen d'évolution de la symptomatologie clinique de six mois. L'état général était altéré avec un index de performance OMS supérieur à 2 chez 48,6 % des malades. L'alcoolotabagisme, facteur de risque toxique exogène principal, n'était retrouvé que dans 16,6 % des cas. L'achalasie et le syndrome de Plummer-Vinson, facteurs de risque spécifiques du carcinome épidermoïde, étaient présents dans 5,6 % des cas. Le reflux gastro-oesophagien, facteur de risque indirect de l'adénocarcinome, était retrouvé dans 9,7 % des cas. La maladie était avancée avec prés de 64 % de stades III et IV selon la classification TNM (UICC 2002). Le taux de résécabilité était de 27,8 %. Aucun de nos patients n'avait bénéficié de traitement néoadjuvant. La survie globale à deux ans était estimée à 2,8 %. Conclusion : Le pronostic péjoratif semblait être majoré par le diagnostic tardif dans notre série. Une amélioration de la survie passerait par une détection précoce. Un transit baryté devant toute odynophagie, suivi d'un examen endoscopique au besoin, est à notre portée. Le mécanisme de la carcinogenèse virale par papillomavirus humain 16 et 18, évoqué mais pas totalement élucidé, est une voie de recherche pour diminuer l'incidence du cancer de l'oesophage chez les populations exposées à ces virus. Mots clés OEsophage · Carcinome épidermoïde · AdénocarcinomeAbstract Aim: The cancer of the oesophagus because of its poor prognosis is a terrifying digestive tumour. The goal of this work was to appreciate the epidemiologic characteristics, anatomo-clinics and to become it of a series of patients. Patients and methods: It was about a retrospective analysis of 72 records of patients in the same team, followed between January 2004 and December 2007. Results: Squamous cell carcinoma accounted for 94.4% of cancers of the oesophagus during this period. The average age of the patients was 48 years with extremes of 16 and 86 years. The diagnosis was late with six months average time of the clinical symptomatology evolution. The general state was faded with an index of performance WHO superior to 2 at 48.6% of the patients. The high alcohol consumption and smoking, principal exogenic toxic factors risk was found only in 16.6% of the cases. Achalasia and PlummerVinson syndrome, squamous cell carcinoma specific factors of risk, were present in 5.6% of the cases. Gastrointestinal oesophageal reflux disease, indirect risk factor of adenocarcino...

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A clinicopathologic review of oesophageal carcinoma in Lagos

Cited by 6 publications

References 0 publications

An uncommon pattern of oesophageal cancer presentation

An uncommon pattern of oesophageal cancer presentation

Systematic review of esophageal cancer in Africa: Epidemiology, risk factors, management and outcomes

Cancer de l’œsophage au Sénégal: revue d’une série de 72 cas

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