A Clinicopathologic Study of 21 Cases of Pancreatic Cystadenocarcinoma

Abstract

Cystadenocarcinomas are rare tumors of the'pancreas. They are half as common as their benign counterpart-the cystadenoma. A The first case reported in the American literature was by Lichtenstein in 1934.9 He described a 44-year-old woman who at autopsy had a large papillary cystadenocarcinoma of the pancreatic tail with metastatic liver nodules and peritoneal seeds. Many isolated reports and several reviews appeared during the subsequent three decades after this initial report. Kennard in 19417 reviewed the world literature and added one case of papillary cystadenocarcinoma. At that time, most tumors either were biopsied only or were treated with internal or external drainage procedures or marsupialization. Sawyer and associates in 195212 found reports of only 29 cases of cystadenocarcinoma and added another to the literature. Most reports concerned clarifying the incidence of the tumors and assessing the malignant potential. Information on the natural history, pathogenesis, and prognosis was not forthcoming because no one institution had a

Mucinous Nonneoplastic Cyst of the Pancreas: A Novel Nonneoplastic Cystic Change?

“…The MCN of the pancreas, as classified by Compagno and Oertel (12) and described by many other authors (13)(14)(15)(16)(17)(18), presents as a well circumscribed unilocular or multilocular cystic tumor, which, in Ͼ90% of the cases, is localized in the body and tail of the pancreas of women (18) No other cystic lesions and neoplasms of the pancreas (1) cause problems in the differential diagnosis of MNCs. Thus MNCs can easily be distinguished from intraductal papillary-mucinous neoplasms by their lack of communication with the duct system (21); from solid pseudopapillary neoplasms by their lack of female predominance, pseudocystic degeneration, and cellular features (22)(23)(24); from serous cystic tumors by their lack of serous differentiation (25); from paraampullary duodenal wall cysts by their location in the duodenal wall and submucosa (2,26); and from the recently described acinar cystic transformation (5) and cystic endocrine tumors (27) by their lack of acinar or endocrine cell differentiation, respectively.…”

Karyotypic abnormalities in tumours of the pancreas

“…The diagnosis of case 10, in which a solitary deletion of the long arm of chromosome 10 was found, was mucinous cystadenocarcinoma, a less malignant cancer than ductal adenocarcinoma (Compagno & Oertel, 1979;Hodgkinson et al, 1978). This patient also had nesidioblastosis, a supposedly paraneoplastic disorder of endocrine pancreatic cells that proliferate reactively in close contact with and complicating disease processes of the exocrine pancreas, e.g., pancreatic carcinomas (Eusebi et al, 1981;Kloppel & Heintz, 1984;Permert et al, 1991).…”

Cystic lesions and neoplasms of the pancreas

“…Among the curable pancreatic tumors are the lesions and neoplasms with a cystic appearance. Until the end of the 1970s, the spectrum of cystic diseases of the pancreas was relatively narrow and consisted mainly of serous and mucinous neoplasms [2][3][4]. In the 1980s, the development and widespread use of new imaging techniques led to the discovery and delineation of new categories of cystic tumors, such as solid and pseudopapillary neoplasms (also known as solid and cystic tumors) [5] and intraductal papillary-mucinous neoplasms (also known as mucinous tumors, mucinous ductal ectasia or intraductal papillary and mucin-hypersecreting tumors) [6].…”