A clinicopathologic study of gynecologic organ involvement at radical cystectomy for bladder cancer

Salem, Hosni; El-Mazny, Akmal

doi:10.1016/j.ijgo.2011.05.026

Cited by 26 publications

(13 citation statements)

References 19 publications

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“…Relative to prostatic involvement by urinary bladder urothelial carcinoma, direct invasion of the vagina or uterus (i.e. without urethral involvement) is rare, occurring in approximately 3–6% of females undergoing radical cystectomy . In addition to direct invasion by urinary bladder carcinoma, the female gynaecological tract may be involved by urothelial carcinoma either via pagetoid or metastatic spread and, although this would not be considered stage pT4a, is associated with poor outcomes .…”

Section: Stage Pt4 Carcinomamentioning

confidence: 99%

“…without urethral involvement) is rare, occurring in approximately 3-6% of females undergoing radical cystectomy. [137][138][139][140][141] In addition to direct invasion by urinary bladder carcinoma, the female gynaecological tract may be involved by urothelial carcinoma either via pagetoid or metastatic spread and, although this would not be considered stage pT4a, is associated with poor outcomes. 142 Anatomical differences in staging also result ultimately in differences in outcomes following radical cystectomy.…”

Section: N V a S I O N O F T H E F E M A L E G Y N A E C O L O G I mentioning

confidence: 99%

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Staging of bladder cancer

et al. 2018

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Urothelial carcinoma of the urinary bladder is a heterogeneous disease with multiple possible treatment modalities and a wide spectrum of clinical outcome. Treatment decisions and prognostic expectations hinge on accurate and precise staging, and the recently published American Joint Committee on Cancer (AJCC) Staging Manual, 8th edition, should be the basis for staging of urinary bladder tumours. It is unfortunate that the International Union Against Cancer (UICC) 8th edition failed to incorporate new data which is considered in the AJCC 8th edition. Thus, the AJCC 8th edition is the focus of this review. Several critical changes and clarifications are made by the AJCC 8th edition relative to the 7th edition. Although the most obvious changes in the 8th edition are in the N (i.e. perivesical lymph node involvement now classified as N1) and M (i.e. M1 is subdivided into M1a and M1b) categories, several points are clarified in the T category (e.g. substaging of pT1 should be attempted). Further optimisation, however, is required. No particular method of substaging pT1 is formally recommended. In this review, these modifications are discussed, as well as points, which require further study and optimisation.

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Section: Stage Pt4 Carcinomamentioning

confidence: 99%

Section: N V a S I O N O F T H E F E M A L E G Y N A E C O L O G I mentioning

confidence: 99%

Staging of bladder cancer

et al. 2018

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“…They concluded that preservation of internal genitalia should be considered in selected cases after careful preoperative assessment. 6 In a larger study from Egypt, pathological findings of gynecologic organs obtained at female RC (n=609) were reported and gynecologic organ involvement was detected in 2.6% of the cases. No primary genital cancers were identified.…”

Section: Discussionmentioning

confidence: 99%

Genitalia Preserving Robotic Radical Cystectomy with Intracorporeal Studer Pouch Formation in the Female: Experience in 5 Cases

Köseoğlu¹,

Kılıç²,

Özkan³

et al. 2021

RSRR

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We present operative, postoperative, oncologic and functional outcomes of genital tract sparing robot-assisted laparoscopic radical cystectomy, bilateral extended pelvic lymph node (LN) dissection and intracorporeal Studer pouch construction on five female patients with bladder cancer. One of the cases had concomitant nephroureterectomy performed due to a non-functioning kidney. Median patient age, mean operation time, median estimated blood loss and mean duration of hospital stay were 59 (39–78), 462 ± 25, 400 (50–970), 8.8 ± 2.5, respectively. Pathologic stages were pTis (n=1), pT1 (n=1), pT3 (n=1), pT4a (n=1) and pT4b (n=1). Mean LN yield was 32.4 ± 8.9. Positive surgical margins were detected in 2 patients with pT4 diseases. Only minor complications developed that were resolved with medical treatment. Two patients had no, 1 patient had mild, and 2 patients had moderate daytime incontinence. One patient had good, 3 patients had fair, and 1 had poor night-time incontinence. This complex robotic surgery can be performed safely with acceptable short-term surgical, oncological and functional outcomes.

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“…Ten percent of the patients had urethral involvement (all had TCC). During late follow up of 50 patients (included two cases with uterine preservation, and in all cases, at least one ovary was preserved), no single ovarian or uterine recurrence was reported [14,15].…”

Section: Definition and Rationale Of Genital-sparing Radical Cystectomentioning

confidence: 99%

Genital Organs-Sparing Radical Cystectomy in Female Patients with Muscle Invasive Urothelial Carcinoma of the Bladder

Salem¹

2017

Bladder Cancer - Management of NMI and Muscle-Invasive Cancer

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There has been considerable interest in urethral-sparing cystectomy and preservation of the gynecological tract to maintain continence mechanism, sexual function, and reproductive function in young patients who undergo radical cystectomy for muscle-invasive bladder cancer and this new technique gained acceptance in many centers. The issue of oncological safety of a urethra and anterior vaginal wall-sparing cystectomy in selected patients has been addressed by several authors. The chapter will discuss the following items: (

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A clinicopathologic study of gynecologic organ involvement at radical cystectomy for bladder cancer

Abstract: Involvement of female internal genitalia in bladder cancer is uncommon. Thus, preservation of these organs in young women undergoing radical cystectomy should be considered in selected cases after careful preoperative assessment.

Cited by 26 publications

References 19 publications

Staging of bladder cancer

Staging of bladder cancer

Genitalia Preserving Robotic Radical Cystectomy with Intracorporeal Studer Pouch Formation in the Female: Experience in 5 Cases

Genital Organs-Sparing Radical Cystectomy in Female Patients with Muscle Invasive Urothelial Carcinoma of the Bladder

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