A clinicopathologic study of mediastinal lesions with special emphasis on thymomas

Shamsuddin, Fatima; Khadilkar, Urmila N; Saha, Debarshi; Sreedharan, Sily

doi:10.18203/2320-6012.ijrms20150299

Cited by 5 publications

(5 citation statements)

References 32 publications

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“…In our study mean age was 54.4 years. This is in agreement with the study by Sperling et al [6] .Our study showed slight male preponderance which was in concordance to the findings by Shamshuddin F et al [7] .…”

Section: Discussionsupporting

confidence: 94%

Clinico-Pathological Analysis of Thymic Epithelial TumoursAn Institutional Study

Sethi

Raju

Augustine

et al. 2018

APALM

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Background: Thymic epithelial tumours are anterior mediastinal neoplasms and they exhibit a spectrum of histomorphological features. Methods: In this study we analysed the clinico-pathological spectrum of thymic epithelial tumors at our institution. It is a retrospective and descriptive study done at our Department of Pathology, Amala Institute of Medical Sciences, Thrissur, Kerala over a period of ten years from August 2008 to August 2018. Histological sections of each case were meticulously analysed. Immunohistochemistry was done if needed. Result: In this study 17 cases of thymic epithelial tumors were analysed. A male preponderance of 58.8% was observed. Age ranged from 24 to 73 years with a mean age range of 54.4 years. Most common histological subtype of thymoma was Type B and Type AB. 4 cases were associated with myasthenia gravis. Masaoka Stage I was commonly observed. Conclusion: Thymic epithelial tumors are a unique group of anterior mediastinal neoplasms which also pose a diagnostic challenge. This study highlights the significance of clinico-pathological correlation and staging of thymic neoplasms.

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Section: Discussionsupporting

confidence: 94%

Clinico-Pathological Analysis of Thymic Epithelial TumoursAn Institutional Study

Sethi

Raju

Augustine

et al. 2018

APALM

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“…Globally, no sex predilection was noted for thymoma. Indian studies have shown male preponderance same like in our study [5,8] . Few studies on thymoma have shown female preponderance in indian patients [9] .…”

Section: Discussionsupporting

confidence: 87%

A clinicopathological study of thymic neoplasms: Nine-year experience at a tertiary care hospital in western Maharashtra, India

Sidhu¹,

Kumar²,

Sengupta³

2020

Int. J. Clin. Diagn. Pathol.

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Introduction:The thymuses are quite rare neoplastic lesions arising in anterior mediastinum seen in the adults. The histological spectrum varied from the encapsulated thymoma to the thymic carcinomas. Further subtyping into various groups on the basis of morphology with immunohistological findings have gained the popularity as depicted by the latest WHO classification of thymomas. A few studies have been done to ascertain the characteristics of thymic neoplasms in Indian population. Methodology: 09 years retrospective analysis of the total 17 thymoma cases reported from year 2011 to 2019 were assessed for histomorphological features with clinical findings, age, sex and staging. Results: The commonest subtypes were of B2 and B1 types with type A, AB and B3 being rare. Mostly the cases were of low grade. Myasthenia Gravis was associated with only 02 thymomas. Conclusion:The morphological classification and staging of thymomas should be used in surgical pathology reporting.

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“…The absence of thymic carcinomas in our surgically resected cases may be because these cases present at an advanced stage of the disease when surgical resection may not be a treatment option. Global data have reported no sex predilection for TETs; however, the Indian studies had shown male predominance similar to the observation in the present series101415171823. Only two studies from India demonstrated a female-predominant population1316.…”

Section: Discussionsupporting

confidence: 82%

“…While relating the status of MG, no significant difference was observed in the association of MG in either group of thymomas divided on the basis of their type. These findings were not in concurrence with worldwide database as well as with Indian data reporting higher incidence of MG in the Type B subgroup11724.…”

Section: Discussioncontrasting

confidence: 74%

“…Its incidence in the Indian population has not been defined and in the power analysis carried out by Marchevsky et al 11, only 20 cases of thymomas were included from India. Among the Indian studies with more than 10 cases121314151617181920, Julka et al 18 had the largest sample with 71 cases (all thymomas) from the same centre; however, histomorphological spectrum was not described in this study. Except for studies by Vaideeswar et al 19 and Sundaram et al 20, none of the studies assessed the histomorphology of TET, especially thymic carcinomas.…”

Section: Discussionmentioning

confidence: 68%

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Histotyping of Indian thymomas

Guleria

Parshad

Malik

et al. 2019

Indian Journal of Medical Research

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Background & objectives:Thymomas are rare, but most common anterior mediastinal lesions. The histomorphologic spectrum of thymic epithelial tumours (TETs) in Indian population has not been explored in depth. This study was aimed to assess the histomorphology of TETs in the Indian patients and correlate clinical parameters with pathological features.Methods:It was a retrospective study conducted in a tertiary referral hospital in north India. All morphologically confirmed cases of TETs since 2009 were included. Clinical details and histology slides were reviewed using the Modified Masaoka-Koga staging system and WHO 2015 classification. Clinicopathological correlation and survival analysis were done. A comparative review from other published Indian studies was performed.Results:A total of 219 cases of TETs (138 resections and 81 biopsies) were identified. The most common histomorphologic type was B2, and the most frequent stage was I. Types A/AB were common in older age (P<0.01). Clinically, higher stage tumours were found mostly in men (P<0.01), and these were Type B thymomas (P<0.01). Myasthenia gravis was more common in women (P<0.02) and in lower stages (P<0.05). Survival analysis revealed significant association between recurrence and tumour stage. Although thymic carcinoma was diagnosed on biopsy, no resectable case was identified.Interpretation & conclusions:Our findings showed that the thymomas in Indian patients were most commonly Stage I tumours of B2 and AB histotypes. Resected thymic carcinomas were conspicuously absent in our study. More studies need to be done to establish the frequency and biology of TETs from India.

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A clinicopathologic study of mediastinal lesions with special emphasis on thymomas

Cited by 5 publications

References 32 publications

Clinico-Pathological Analysis of Thymic Epithelial TumoursAn Institutional Study

Clinico-Pathological Analysis of Thymic Epithelial TumoursAn Institutional Study

A clinicopathological study of thymic neoplasms: Nine-year experience at a tertiary care hospital in western Maharashtra, India

Histotyping of Indian thymomas

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