A Clinicopathologic Study of Ureteropelvic Obstructions

Lich, Robert; Barnes, Malcolm L.

doi:10.1016/s0022-5347(17)66574-1

Cited by 14 publications

(4 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Early descriptions of the UPJ alterations were those of extensive fibrosis and muscular attenuation [1][2][3][4][5][6][7][8]. In our study the changes in the UPJ could not be distinguished by etiology (extrinsic or intrinsic), at least in part due to the fact that some of our cases had extensive perifascicular fibrosis and made the distinction impossible at this apparent late stage.…”

Section: Discussioncontrasting

confidence: 63%

“…Ureteropelvic junction (UPJ) obstruction, either due to "intrinsic" factors (idiopathic) or by compression of aberrant vessels [1][2][3][4][5][6][7][8], is a common cause of ureteral obstruction in childhood. The histological appearance of UPJ obstruction has received varying descriptions ranging from segmental smooth muscle attenuation with predominance of longitudinal fibers to diffuse loss of muscle or muscle disorganization [1][2][3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…The histological appearance of UPJ obstruction has received varying descriptions ranging from segmental smooth muscle attenuation with predominance of longitudinal fibers to diffuse loss of muscle or muscle disorganization [1][2][3][4][5][6][7][8]. The valves that have been noted at the UPJ are thought to result from herniated tissue at the site of the muscular abnormality [3].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ureteropelvic junction obstruction: morphological and clinical studies

Zhang

Peters

Rosen

2000

Pediatric Nephrology

View full text Add to dashboard Cite

This study included 27 patients with ureteropelvic (UPJ) obstruction. Both renal parenchyma and the junctional abnormality were examined and correlated with clinical findings. Renal biopsies were categorized into grades 1-4. Those with normal or minimal findings (grade 1 and 2, respectively) had excellent renal function as assessed by radionuclide studies. Those with grade 4 had severe histological abnormalities associated with poor renal function. Grade 3 renal changes were seen in patients whose renal function varied greatly and did not correlate with the extent of the limited histological abnormalities. Although there was great variation in the renal biopsies, glomerulosclerosis was a consistent finding, associated with extracapillary proliferation and periodic acid-Schiff-positive material (? Tamm-Horsfall protein) in the urinary space of glomeruli in 91% (10/11) of grade 3 or 4 renal biopsies. No extracapillary proliferation was seen in grade 1 renal biopsies. The UPJ obstruction area was consistently inflamed and markedly thickened due to varying degrees of perifascicular fibrosis and muscular hypertrophy. Extensive fibrosis with associated muscular atrophy was the most-severe change in this spectrum.

show abstract

Section: Discussioncontrasting

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ureteropelvic junction obstruction: morphological and clinical studies

Zhang

Peters

Rosen

2000

Pediatric Nephrology

View full text Add to dashboard Cite

show abstract

“…Acquired stenosis -Uretero-pelvic Obstruction Aetiology -Case reports der Peristaltik wird von Uson et al, hingewiesen (8). Auch Mukosafalten wurden als Ablaufhindernis beschrieben (5). Solange keine eindeutigen Ursachen einer erworbenen Harnleiterenge (Tumorkompression, Stein) nachgewiesen sind, gilt die subpelvine Stenose als angeborene, lebenslang bestehende Erkrankung (2).…”

Section: Key-wordsunclassified