A clinicopathological analysis of primary cutaneous lymphomas: A 6-year observational study at a tertiary care center of south India

Khader, Anza; Manakkad, ShinyPadinjarayil; Shaan, Mohammed; Pillai, SaritaSasidharan; Riyaz, Najeeba; Manikoth, PBinitha; Muhammed, Kunnummal; Balakrishnan, Sunitha

doi:10.4103/0019-5154.193665

Cited by 15 publications

(9 citation statements)

References 30 publications

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“…Male preponderance was noted with the mean age being 61.9 years. In a six-year study of 35 cases of cutaneous T cell lymphomas by Khader et al .,[ 18 ] the authors report similar male preponderance and a mean age of onset of 52.66 years. Majority of cases in their study were of T cell Lymphoma (94.3%).…”

Section: Discussionmentioning

confidence: 76%

A Clinicopathological Study of Skin Tumors from a Tertiary Care Centre in North India

Goel¹,

Kaur

Garg

et al. 2021

Indian Dermatology Online Journal

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Background: There is a huge spectrum of skin tumors which can be confused clinically with malignancies, particularly when they are pigmented or inflamed, and histopathological examination of a biopsy specimen is required to establish a definitive diagnosis and to facilitate appropriate intervention and follow up. Aim: To evaluate all skin tumors and categorize them according to their origin. Methods: The present study was conducted over a period of 4 years (July 1, 2013 to June 31, 2017) comprising of 1.5 years prospective and 2.5 years retrospective analysis in the departments of Dermatology and Pathology, at a tertiary hospital in North India. All specimens of skin tumors were analyzed grossly and microscopically. Immunohistochemistry was done wherever possible. Results: A total of 232 skin tumors were seen; of which 123 cases were benign (53.0%) and 109 cases were malignant (47.0%). The mean age of patients with benign and malignant skin tumors was 40.3 ± 19.9 and 60.8 ± 14.8 years, respectively. The most common site was face (n = 106; 45.7%) followed by limbs (n = 44; 19.0%). The male:female ratio of benign and malignant tumors was 1.01:1 and 1.31:1, respectively. Among the benign tumors, keratinocytic tumors were the commonest (n = 57; 46.3%) followed by the melanocytic tumors (n = 37; 30.1%) and appendageal tumors (n = 29; 23.6%). The most common malignant skin tumors were the keratinocytic tumors (n = 87; 79.8%) followed by 12 cases (11%) of hematolymphoid tumors and five cases (4.6%) each of melanocytic and appendageal tumors. Limitations: The lack of clinical and dermatoscopic correlation and inclusion of retrospective data are the limitations of this study. Conclusions: Skin tumors affect people of all ages. The benign tumors are seen in the younger age group as compared to malignant tumors. Face is the most common site and keratinocytic tumors are the most common skin tumors in both benign and malignant categories.

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Section: Discussionmentioning

confidence: 76%

A Clinicopathological Study of Skin Tumors from a Tertiary Care Centre in North India

Goel¹,

Kaur

Garg

et al. 2021

Indian Dermatology Online Journal

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“…A similar study from South India by Khader et al . [ 14 ] among 35 cases also showed various types of lesions in CTCL. In our study, we found predominantly superficial dermal involvement in 13/21 (61.9%) of cases of CTCL.…”

Section: Discussionmentioning

confidence: 98%

“…A similar study from South India by Khader et al . [ 14 ] showed a male-to-female ratio of 2.5:1, and the age ranged from 30–91 years with a median age of 53 years.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological spectrum of cutaneous lymphomas and distinction of early mycosis fungoides from its mimics—A retro-prospective descriptive study from Southern India

Durgadevi

Srinivas

Chandrashekar

et al. 2022

Indian Dermatol Online J

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Background: Cutaneous lymphomas (CLs) could be either primary (PCL) or secondary; the former comprises cutaneous T-cell lymphomas (CTCLs) and cutaneous B-cell lymphomas (CBCLs). Mycosis fungoides (MF) is the most common PCL. Diagnosis of early MF and distinguishing it from benign inflammatory mimics is challenging. This study aims to assess the clinicopathological spectrum of CL and to characterize early MF from its mimics using clinical characteristics, histopathological features, and ancillary techniques. Materials and Methods: This retro-prospective descriptive study was conducted in a tertiary-care institute, for over 5 years. Clinically as well as histopathologically suspected and biopsy-proven CL and their mimics were included. Cases were reviewed and subgrouped based on clinical and histopathological parameters and immunohistochemistry (IHC). Data were analyzed using descriptive statistics and a Chi-square test at a 5% level of significance. Results: Among PCL, CTCL comprised 84% (21/25) and CBCL was 16% (4/25); the most common CTCL was MF at 81% (17/21). Histologically, atypia of dermal infiltrate (100%), epidermotropism (91.7%), basal alignment of lymphocytes (91.7%), clear haloed cells (91.7%), wiry collagen (66.7%), grandiosity sign (50%), eccrine infiltration (66.7%), and follicular infiltration (50%) were significantly associated with early MF. Spongiosis (84.6%), pigment incontinence (84.6%), exocytosis (76.9%), and parakeratosis (76.9%) were significantly associated with inflammatory mimics. There was no significant difference in the downregulation pattern of CD7 ( P = 0.206) between early MF and its mimics. The four cases of CBCL in our study were plasmablastic lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, and lymphoblastic lymphoma. Conclusion: MF was the most common PCL. Histological parameters showed a significant difference, whereas IHC did not show any significant difference between early MF and its mimics.

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“…We found that type of lesions were mycosis fungoides in 42, adult T-cell lymphoma/leukemia in 30 and peripheral T-cell lymphoma in 10 patients. Khader et al [9] conducted a study among 35 cases, 33 (94.3%) were T-cell, and 2 (5.7%) were B-cell lymphomas. The mean age was 52.66, and the male to female ratio was 2.…”

Section: Discussionmentioning

confidence: 99%

Assessment of cases of primary cutaneous lymphomas- A clinical study

Agarwal¹,

Srivastava²,

Tandon³

2021

Int. J. Dermatol. Venereology Leprosy Sci.

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Background: Primary cutaneous lymphomas represent the second most common group of extranodal non-Hodgkin lymphoma after primary gastrointestinal lymphomas. The present study was conducted to assess cases of primary cutaneous lymphomas. Materials and methods: 82 cases of primary cutaneous lymphomas both genders were recruited. Duration of illness, presence of pruritus, family history, and occupational history was recorded. Results: Out of 82 patients, males were 48 and females were 34. Type of lesions were mycosis fungoides in 42, adult T-cell lymphoma/leukemia in 30 and peripheral T-cell lymphoma in 10 patients. Type of lesions were macules in 16, papules in 20, plaques in 22, macules & papules in 10, papules & plaques in 4, pustules and nodules in 6, plaques and nodules in 4 cases. The difference was significant (P< 0.05). Conclusion: Type of lesions were mycosis fungoides, adult T-cell lymphoma/leukemia and peripheral T-cell lymphoma in 10 patients. Type of lesions were macules, papules, plaques, macules & papules.

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A clinicopathological analysis of primary cutaneous lymphomas: A 6-year observational study at a tertiary care center of south India

Cited by 15 publications

References 30 publications

A Clinicopathological Study of Skin Tumors from a Tertiary Care Centre in North India

A Clinicopathological Study of Skin Tumors from a Tertiary Care Centre in North India

Clinicopathological spectrum of cutaneous lymphomas and distinction of early mycosis fungoides from its mimics—A retro-prospective descriptive study from Southern India

Assessment of cases of primary cutaneous lymphomas- A clinical study

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