A clinicopathological study of 267 patients with diabetic kidney disease based on the renal pathology society – 2010 classification system

Chandragiri, S; Raju, Sree Bhushan; Surendra, M; Goli, R; Nimmagadda, Sridhar; Uppin, Megha S

doi:10.4103/ijn.ijn_424_17

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…Our patient presented persistent microalbuminuria 1 year later FMF diagnosis, so a renal biopsy was performed that revealed slight and irregular thickening of the lamina densa of some glomerular capillaries. This histopathological finding was compatible with diabetic nephropathy, so treatment with Ramipril was started [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

A case report of a boy suffering from type 1 diabetes mellitus and familial Mediterranean fever

et al. 2021

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Background Type 1 diabetes mellitus could be associated with other autoimmune diseases, such as autoimmune thyroid disease, celiac disease, but the association with Familial Mediterranean Fever is rare, we describe a case of a boy with type 1 Diabetes Mellitus associated with Familial Mediterranean Fever (FMF). Case presentation A 13 year old boy already suffering from Diabetes Mellitus type 1 since the age of 4 years, came to our attention because of periodic fever associated with abdominal pain, chest pain and arthralgia. The fever appeared every 15–30 days with peaks that reached 40 °C and lasted 24–48 h. Laboratory investigation, were normal between febrile episodes, but during the attacks revealed an increase in inflammatory markers. Suspecting Familial Mediterranean Fever molecular analysis of MEFV gene, was performed. The genetic analysis showed homozygous E148Q mutation. So Familial Mediterranean Fever was diagnosed and colchicine treatment was started with good response. Conclusion Familial Mediterranean Fever could be associated with other autoimmune diseases such as Ankylosing Spondylitis, Rheumatoid Arthritis, Polyarteritis Nodosa, Behcet disease, Systemic Lupus, Henoch-Schönlein Purpura, and Hashimoto’s Thyroiditis. Association of type 1 Diabetes Mellitus and Familial Mediterranean Fever has been newly reported in the medical literature, this is the third association of these two diseases described in the medical literature so far.

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Section: Discussionmentioning

confidence: 99%

A case report of a boy suffering from type 1 diabetes mellitus and familial Mediterranean fever

et al. 2021

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Characterizing predictors of non-diabetic kidney disease (NDKD) in diabetic patients

et al. 2021

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The renal apical sodium‐dependent bile acid transporter expression rescue attenuates renal damage in diabetic nephropathy via farnesoid X receptor activation

Li,

Pang,

Guo

et al. 2024

Nephrology

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AimBile acids (BA) function as signalling molecules regulating glucose‐lipid homeostasis and energy expenditure. However, the expression of the apical sodium‐dependent bile acid transporter (ASBT) in the kidney, responsible for renal BA reabsorption, is downregulated in patients with diabetic kidney disease (DKD). Using the db/db mouse model of DKD, this study aimed to investigate the effects of rescuing ASBT expression via adeno‐associated virus‐mediated delivery of ASBT (AAVASBT) on kidney protection.MethodsSix‐week‐old male db/db mice received an intraparenchymal injection of AAVASBT at a dose of 1 × 1011 viral genomes (vg)/animal and were subsequently fed a chow diet for 2 weeks. Male db/m mice served as controls. For drug treatment, daily intraperitoneal (i.p.) injections of the farnesoid X receptor (FXR) antagonist guggulsterone (GS, 10 mg/kg) were administered one day after initiating the experiment.ResultsAAVASBT treatment rescued renal ASBT expression and reduced the urinary BA output in db/db mice. AAVASBT treatment activated kidney mitochondrial biogenesis and ameliorated renal impairment associated with diabetes by activating FXR. In addition, the injection of FXR antagonist GS in DKD mice would reverse these beneficial effects by AAVASBT treatment.ConclusionOur work indicated that restoring renal ASBT expression slowed the course of DKD via activating FXR. FXR activation stimulates mitochondrial biogenesis while reducing renal oxidative stress and lipid build up, indicating FXR activation's crucial role in preventing DKD. These findings further suggest that the maintenance of renal BA reabsorption could be a viable treatment for DKD.

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A clinicopathological study of 267 patients with diabetic kidney disease based on the renal pathology society – 2010 classification system

Cited by 4 publications

References 14 publications

A case report of a boy suffering from type 1 diabetes mellitus and familial Mediterranean fever

A case report of a boy suffering from type 1 diabetes mellitus and familial Mediterranean fever

Characterizing predictors of non-diabetic kidney disease (NDKD) in diabetic patients

The renal apical sodium‐dependent bile acid transporter expression rescue attenuates renal damage in diabetic nephropathy via farnesoid X receptor activation

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