A Clinicopathological Study of Leiomyoma Variants of the Uterus

Kumar, Bindu Vijay; Manakkattu, Shiny Padinjarayil; PuthenParampath, Sathi; Ajitha, B. K.

doi:10.1007/s40944-019-0349-3

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…In a study by Manjula K [6] et al, of the total 12,285 surgical specimens received for histopathological examination in the department during the study period, 1,832 were hysterectomies and 13 were myomectomy specimens [6,7] . In a study by Bindu Vijaya Kumar [8] et al, hysterectomy was done in 58.9%, and myomectomy were performed in 41.4% [9] . In a study by Budihal [10] et al, among 12,285 surgical specimens received for histopathological examination during the study period, 1914 were hysterectomies, 25 were myomectomies, 3 were debulking specimens and one was polypectomy specimen [10,11] .…”

Section: Discussionmentioning

confidence: 99%

Uterine mesenchymal tumors: One year institutional experience in a tertiary care centre in South India

Marla¹,

Bharathi²,

Cs³

2020

Int. J. Clin. Diagn. Pathol.

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Background Uterine mesenchymal tumors have been conventionally classified into two broad categories; Smooth Muscle Tumors (SMT) and Endometrial Stromal Tumors (EST). Most common being Smooth muscle tumors, its accurate categorization by light microscopic examination is important and at times can be challenging. Here we discuss Institutional experience of Uterine mesenchymal tumors for 1 year in a tertiary care centre in South India. Aim To determine the various histomorphological types of Uterine Mesenchymal Tumors and to study its correlation with Clinico-Pathological findings. Materials and Methods It is a descriptive record based study. Study was carried out in a tertiary care centre in South India. All the consecutive hysterectomy and myomectomy cases received in the department of Pathology were studied. Cases from women aged between 20-80 years, received from January 2019 to December 2019 and diagnosed as mesenchymal tumors of the uterus were retrieved and reviewed. Results In our study period of 12 months, a total of 246 cases were noted. There were 212 Hysterectomy specimens and 34 Myomectomy specimens. Average size of the lesions was 4.9 cm and average age at presentation was 45yrs. Benign tumors were more common compared to malignant tumors. Out of total number of 246 cases, 243 were Leiomyoma and its variants. Typical leiomyoma were 179 cases and variants included Leiomyoma with hyaline change 34 cases, which was commonest followed by adenomyoma 11 cases, cellular leiomyoma 8 cases, leiomyoma with myxoid change 4 cases, lipoleiomyoma 2 cases, atypical leiomyoma 2 cases and leiomyoma with red degeneration and leiomyoma with amianthoid fibers 1 case each. Among malignant tumors 1 case was Leiomyosarcoma (LMS) and 2 were Endometrial Stromal Sarcoma (ESS). Conclusion It is important to differentiate benign and malignant mesenchymal tumors due to differences in their clinical outcome. Most common being Smooth muscle tumors, its accurate categorization by light microscopic examination is important and at times can be challenging. Role of surgical pathologist in making this distinction, especially in difficult cases cannot be underestimated. Although Immunohistochemical stains are helpful in establishing the final diagnosis, the morphologic features are superior to all the other ancillary techniques for this group of neoplasms. Recent application of molecular techniques has identified numerous lesions with distinctive genetic abnormalities and clinicopathological characteristics.

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Section: Discussionmentioning

confidence: 99%

Uterine mesenchymal tumors: One year institutional experience in a tertiary care centre in South India

Marla¹,

Bharathi²,

Cs³

2020

Int. J. Clin. Diagn. Pathol.

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A Clinicopathological Study of Uterine Leiomyoma in Women Above 30 Years in a Tertiary Care Hospital of Assam

Ahmed¹,

Dowerah²,

Das³

2022

IJAR

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Background: Leiomyoma of uterus is the most common benign neoplasm in women. The clinical presentation differs from patients to patients. Due to the complex interactions between steroid hormones, growth hormones and mutations in the myometrium, leiomyoma undergoes degenerative changes and coexists with varied benign and malignant lesions of the endomyometrium and cervix. Aims And Objectives: a) To study the incidence of leiomyoma in hysterectomy specimens. b) To study the histopathological variants and secondary changes in leiomyoma. c) To study the associated histopathological changes in the endomyometrium and cervix. Material And Methods: The present study is conducted in the Department of Pathology, Fakhruddin Ali Ahmed Medical College, Barpeta from July, 2019 to December, 2020. A total of 140 hysterectomy specimens with or without salpingo-oophorectomy of women above 30 years were received. 77 cases diagnosed as leiomyoma on histopathological examination were included in the study and relevant clinical data were analyzed. Result: Uterine leiomyomas occurred mostly in women aged 31-40 years (50.65%). Menorrhagia (58.44%) and dysmenorrhea (32.47%) were the chief clinical manifestations. Most common location was intramural (68.83%). Secondary changes were observed in 20.78% cases of uterine leiomyoma with hyalinization as commonest histopathological nding. Leiomyoma variants was seen in 3.90 % and all of them were cellular leiomyoma. Associated endometrial hyperplasia without atypia (67.53%) and chronic cervicitis (71.42%) was the dominating endometrial and cervical pathology respectively. 33.77% cases had dual pathology of leiomyoma and adenomyosis. Conclusion: A detail and meticulous analysis of the indications for hysterectomy alongwith histopathological ndings play a signicant role in patient management and surveillance.

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A Clinicopathological Study of Leiomyoma Variants of the Uterus

Cited by 2 publications

References 16 publications

Uterine mesenchymal tumors: One year institutional experience in a tertiary care centre in South India

Uterine mesenchymal tumors: One year institutional experience in a tertiary care centre in South India

A Clinicopathological Study of Uterine Leiomyoma in Women Above 30 Years in a Tertiary Care Hospital of Assam

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