A clinicopathological study of malignant odontogenic tumours

Abstract

Malignant odontogenic tumours are considered rare central odontogenic lesions. Awareness of their existence, rapid diagnosis and successful treatment using surgery, radiation and/or chemotherapy is critical to patient survival.

Epidemiology, prognostic factors, and management of malignant odontogenic tumors: an analysis of 295 cases

“…MOTs have been found to be difficult to specifically diagnose because of the variations in pathogenesis, histopathologic features, and biologic behavior, and the overall rarity of these diseases. 23 This study, to our knowledge, is the first to report survival data for both OS and DSS of MOTs, with a 5-year survival rate of 54% and 67%, respectively. Previous studies of specific odontogenic tumors have reported 5-year survival rates for OS alone to be 72.9% for ameloblastic carcinoma, 73% for odontogenic ghost cell carcinoma, and 30% for primary intraosseous carcinoma 30%.…”

“…This age at diagnosis, male predilection, and high frequency of presentation in the mandible is consistent with cases reported in the previous MOT literature. 7,10,23 Increased age at diagnosis was found to be associated with worse OS and DSS in univariate analysis and multivariate analysis of the overall cohort and stage I/II patients. Advanced age may decrease the rate of survival as a result of an age-dependent T-lymphocyte depletion, a higher propensity to development of metastatic disease, differences in management based on age, or an intolerance to the cytotoxic effects of chemotherapy.…”

“…2,7,8,23 Because of this rarity, large population data with long-term follow-up of MOTs are limited. This has resulted in controversy surrounding the prognostic factors, management, and treatment modalities of MOTs.…”

“…This is especially an issue with MOTs because it can be difficult to differentiate an MOT from its benign counterpart and confirm that it has an odontogenic origin. 7,23 The other limitation of the SEER database is that it lacks information on the extent of surgical resection, margin status, patient comorbidities, and administration of chemotherapy. Despite these limitations, the SEER database has proven in previous studies to improve the overall knowledge of rare head and neck malignancies and has provided, to our knowledge, the largest population-based study with long-term follow-up of patients diagnosed with MOT.…”

Clear cell odontogenic carcinoma: report of 7 new cases and systematic review of the current knowledge

“…38,40,[72][73][74][75][76] Subsequently, the studies reporting inconsistent histologic diagnosis or those from which the clinicopathologic data retrieval was difficult were excluded. [58][59][60][61][62][63][64][65][66][67][68][69][70][71][73][74][75][76] Data on sociodemographic characteristics, clinical features, treatment, follow-up, and outcomes were collected and plotted for each study. Ultimately, this review resulted in 87 well-documented cases of CCOC retrieved from 53 articles.…”