A close positive correlation between malodor and sweating as a marker for the treatment of axillary bromhidrosis with botulinum toxin A

He, Jinguang; Wang, Tao; Dong, Jie

doi:10.3109/09546634.2011.594869

Cited by 25 publications

(14 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For many people, the malodor of bromhidrosis is a social handicap, interfering greatly with one's quality of life (Lee et al, 2006). Surgical ablation of apocrine glands offers the most effective way to permanently eliminate or reduce axillary malodor and hyperhidrosis (He, Wang, & Dong, 2012).…”

Section: Discussionmentioning

confidence: 99%

A refined surgical treatment modality for bromhidrosis: Subcutaneous scissor with micropore

Dai

2017

Dermatologic Therapy

View full text Add to dashboard Cite

Axillary bromhidrosis has a strong negative effect on one's social life. A high success rate and few complications are criteria for a surgical treatment. The objective of this study was to evaluate a new surgical treatment modality for bromhidrosis: subcutaneous scissor with micropore. Twenty patients with bromhidrosis were treated. Patients were placed in a supine position with their treated arms abducted to 110°. After injection of 60 mL of tumescent solution into each axilla, one small incision was made at the middle axillary of the hair-bearing area. The whole hair-bearing skin was undermined at the level of the superficial fat to obtain adequate skin eversion. The flaps were everted to offer full exposure of the apocrine glands, and meticulous excision of each gland was performed. Both sides were punctured with scalpel. The micropore was used for drainage, and whose width was just 3 mm. Finally, the incisions were re-approximated, and bulky compressive dressings were applied to the area for 72 hours. Of the 40 axillae (20 patients), 34 (85.0%) showed excellent results, and six (15.0%) had good results. Malodor was significantly decreased. There were no serious complications. This technique can produce excellent results with a lower complication rate than most other surgical modalities and can be performed without costly equipment.

show abstract

Section: Discussionmentioning

confidence: 99%

A refined surgical treatment modality for bromhidrosis: Subcutaneous scissor with micropore

Dai

2017

Dermatologic Therapy

View full text Add to dashboard Cite

show abstract

“…Thirteen patients from the experimental arm achieved an at least 50% reduction in VAS score, compared with none of the placebo patients. BTX-A patients showed a significant reduction in sleep scores between baseline and week 2, which remained unchanged until 16th week (He et al, 2012).…”

Section: Post-herpetic Neuralgiamentioning

confidence: 91%

Botulinum toxin: Non cosmetic and off-label dermatological uses

Alghamdi

Alghanemy

Joharji

et al. 2015

Journal of Dermatology & Dermatologic Surgery

View full text Add to dashboard Cite

Botulinum toxin (BT-A) is a neurotoxin which is produced by the Gram-positive anaerobic bacterium Clostridium botulinum. The efficacy of Botulinum toxin in treating hyperhidrosis and the glabellar lines is well known and FDA approved.Because BT-A inhibits the release of acetylcholine and many other neurotransmitters such as norepinephrine and substance P at the level of nerve ending, this toxin has been used to treat a lot of dermatological disorders which are thought to be triggered by these neurotransmitters.In this article we are discussing the medical off-label uses of BT-A in dermatology.ª 2014 Production and hosting by Elsevier B.V. on behalf of King Saud University.

show abstract

“…Axillary bromhidrosis is a condition in which body odor is induced by the interaction between apocrine gland secretions and bacteria [110] . In 2012, He et al [110] enrolled 67 patients with axillary bromhidrosis. Each axilla was injected with 50 U of BoNT-A, and the follow-up was done every month.…”

Section: Chromhidrosis and Bromhidrosismentioning

confidence: 99%

Botulinum Toxin Off-Label Use in Dermatology: A Review

Campanati

Martina

Giuliodori

et al. 2017

Skin Appendage Disord

View full text Add to dashboard Cite

focal hyperhidrosis, aesthetic medicine and neurological conditions with a strong efficacy and safety profile [1][2][3][4][5][6][7] . The enormous therapeutic potential of this drug contributed to a number of broad applications, especially in dermatological diseases. A large number of these indications are still lacking shared, approved protocols for dilution, doses, and timing of follow-up and retreatment. Also the injection techniques are still debated, depending on the operator's experience, angle of injection and depth. We have previously published a novel injection approach consisting in a needle adaptor that ensures a uniform administration of the toxin [3] . The aim of this review was to collect and analyze the published data concerning the most relevant off-label indications of BoNT-A. MethodsA PubMed search from 1950 to July 2016 was performed to identify any reports on the use of botulinum toxin in off-label indications concerning dermatology. We detected these articles using the terms "botulinum toxin dermatology," "botulinum toxin treatment," "botulinum toxin off-label," and meshed with a secondary search of studies pertaining to each indication. Only studies in English were reviewed. All studies that met the criteria were included and summarized in this review. KeywordsBotulinum toxin · Off-label therapy · Keloids · Hidradenitis suppurativa · Folds dermatitis Abstract Background: Botulinum toxin is a neurotoxin produced by the bacterium Clostridium botulinum which causes a flaccid muscle paralysis. It is currently used for aesthetic treatments and in the focal hyperhidrosis. Recently, botulinum toxin has also been used experimentally in many other dermatological conditions with good results. Objective: To review and analyze the possible botulinum toxin off-label applications published. Methods: A retrospective review of the published data was conducted. Conclusions: this potent drug can lead to several off-label indications of interest for dermatologists. Further clinical trials are still needed to better understand the real efficacy and safety of these applications and to standardize injection and dose protocols.

show abstract

A close positive correlation between malodor and sweating as a marker for the treatment of axillary bromhidrosis with botulinum toxin A

Abstract: BTX-A ameliorates malodor mainly by the inhibition of eccrine and apoeccrine sweating but no apocrine sweating. A close positive correlation between malodor and sweating is the indication for BTX-A treatment.

Cited by 25 publications

References 24 publications

A refined surgical treatment modality for bromhidrosis: Subcutaneous scissor with micropore

A refined surgical treatment modality for bromhidrosis: Subcutaneous scissor with micropore

Botulinum toxin: Non cosmetic and off-label dermatological uses

Botulinum Toxin Off-Label Use in Dermatology: A Review

Contact Info

Product

Resources

About