A Closed Chemobrionic System as a Biochemical Delivery Platform

Angelis, Georgios I.; Zayed, Dimitris Nabil; Karioti, Anastasia; Lazari, Diamanto; Kanata, Ειrini; Sklaviadis, Theodoros; Pampalakis, Georgios

doi:10.1002/chem.201903255

Cited by 10 publications

(14 citation statements)

References 19 publications

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“…The ability of chemical gardens to encapsulate and release therapeutic cargos only adds to the potential usability of these materials in the field of regenerative medicine and tissue engineering [36–38] . Incorporating growth factors and proteins such as vascular endothelial growth factor (VEGF), [39–41] bone morphogenic protein‐2 (BMP‐2), [41,42] and bone morphogenic protein‐7 (BMP‐7), also known as recombinant human osteogenic protein‐1 (OP‐1), [43] could improve the bone regeneration process further.…”

Section: Resultsmentioning

confidence: 99%

Exploring the Formation of Calcium Orthophosphate‐Pyrophosphate Chemical Gardens

et al. 2021

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Chemical gardens are characterised by the self‐assembly of mineralised abiotic architectures. Utilising the fundamental building blocks of bone mineral, namely calcium and orthophosphate ions, chemical gardens that recapitulate microstructural and compositional features of hard tissue can be grown. Interplay between orthophosphate and pyrophosphate species is highly relevant to natural mineral deposition processes, though this has yet to be explored in the context of generating biologically relevant chemical gardens. Here, tubular calcium orthophosphate‐pyrophosphate chemical gardens were grown from the interface between calcium loaded hydrogels ([Ca2+]=1 M) layered with different orthophosphate‐pyrophosphate solutions ([Pi]+[PPi]=0.7 M). We determine the effect of solution pyrophosphate content on chemical garden morphology and growth rate. Extracted structures were analysed by means of powder X‐ray diffraction (XRD), Raman spectroscopy, scanning electron microscopy (SEM) and X‐ray fluorescence spectroscopy (XRF), revealing orthophosphate‐pyrophosphate solution dependent differences in precipitated mineral crystallinity, composition and microstructure, respectively. Lastly, the potential application of the structures is discussed in the context of tissue engineering and regenerative medicine.

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Section: Resultsmentioning

confidence: 99%

Exploring the Formation of Calcium Orthophosphate‐Pyrophosphate Chemical Gardens

et al. 2021

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“…This can open a great opportunity to create nanostructures for bio-materials that have high biocompatibility with living cells and tissues. Chemical gardens may also be worth considering with regard to selective adsorption-desorption processes of interest, for example, for the slow release of drugs [1].…”

Section: Self-assembled Materials Architectures and Their Possible Technological Applicationsmentioning

confidence: 99%

Chemobrionics: From Self-Assembled Material Architectures to the Origin of Life

et al. 2020

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Self-organizing precipitation processes, such as chemical gardens forming biomimetic micro- and nanotubular forms, have the potential to show us new fundamental science to explore, quantify, and understand nonequilibrium physicochemical systems, and shed light on the conditions for life's emergence. The physics and chemistry of these phenomena, due to the assembly of material architectures under a flux of ions, and their exploitation in applications, have recently been termed chemobrionics. Advances in understanding in this area require a combination of expertise in physics, chemistry, mathematical modeling, biology, and nanoengineering, as well as in complex systems and nonlinear and materials sciences, giving rise to this new synergistic discipline of chemobrionics.

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“…However, it is now well‐established that chemical gardens have applications in cement chemistry, in metal corrosion, and in the formation of hydrothermal vents [1] . Other more modern applications include the production of energy as fuel cells, [6] as photosynthesis cells [7] and as new biochemical delivery systems [8] . Finally, the study of chemical gardens is important in the origin of life research [1] and certain chemobrionic structures have been demonstrated to catalyze the formation of DNA/RNA bases from the prebiotic molecule formamide [9] …”

Section: Figurementioning

confidence: 99%

“…[1] Other more modern applications include the production of energy as fuel cells, [6] as photosynthesis cells [7] and as new biochemical delivery systems. [8] Finally, the study of chemical gardens is important in the origin of life research [1] and certain chemobrionic structures have been demonstrated to catalyze the formation of DNA/RNA bases from the prebiotic molecule formamide. [9] Formation of chemical gardens based on gold salts was first described by Glauber in 1646 in his book Furni Novi Philosophici, and were yellow colored plant-like structures.…”

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confidence: 99%

The Generation and Study of a Gold‐Based Chemobrionic Plant‐Like Structure

2020

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The generation of chemical gardens based on tetrachloroauric acid and silicate is presented. The structures were studied with SEM, XRD and micro‐Raman spectroscopy and a new mechanism that participates in their development was revealed. Specifically, the structures were decorated with metallic Au that is derived during the process of plant‐like growth. Probably, the instability of gold salts and hydroxides on silica templates accounts for their reduction to metallic Au.

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A Closed Chemobrionic System as a Biochemical Delivery Platform

Cited by 10 publications

References 19 publications

Exploring the Formation of Calcium Orthophosphate‐Pyrophosphate Chemical Gardens

Exploring the Formation of Calcium Orthophosphate‐Pyrophosphate Chemical Gardens

Chemobrionics: From Self-Assembled Material Architectures to the Origin of Life

The Generation and Study of a Gold‐Based Chemobrionic Plant‐Like Structure

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