A Closed-Circuit Rebreather for the Characterization of Denitrogenation

Hugon, Julien; Rostain, Jean-Claude; Gardette, B

doi:10.3357/asem.2811.2010

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…With a simple apparatus and a high oxygen flow, a large percentage of the nitrogen stored in the body can be expelled within 1 hour. 64 If such a device is not available, a non-rebreathing face mask with one-way expiratory valves that is attached to high oxygen flows should facilitate denitrogenation. 65,66 There is no single well defined threshold below which oxygen toxicity will not occur.…”

Section: Options For Treatmentmentioning

confidence: 99%

Atherosclerosis: Viewing the Problem from a Different Perspective Including Possible Treatment Options

Goldberg

2011

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This paper proposes that atherosclerosis is initiated by a signaling event that deposits calcium hydroxyapatite (Ca-HAP). This event is preceded by a loss of mechanical structure in the arterial wall. After Ca-HAP has been deposited, it is unlikely that it will be reabsorbed because the solubility product constant (K sp ) is very small, and the large stores of Ca ) ions, and it is proposed that anions associated with cholesterol ester hydrolysis and, in very small quantities, the enolate of 7-ketocholesterol could also displace the OH − of Ca-HAP, forming an ionic bond. The free energy of hydration of Ca-HAP at 310 K is most likely negative, and the ionic radii of the anions associated with the hydrolysis of cholesterol ester are compatible with the substitution. Furthermore, examination of the pathology of atherosclerotic lesions by Raman and NMR spectroscopy and confocal microscopy supports deposition of Ca-HAP associated with cholesterol. Investigating the affinity of intermediates of cholesterol hydrolysis for Ca-HAP compared to lipoproteins such as HDL, LDL, and VLDL using isothermic titration calorimetry could add proof of this concept and may lead to the development of a new class of medications targeted at the deposition of cholesterol within Ca-HAP. Treatment of acute ischemic events as a consequence of atherosclerosis with denitrogenation and oxygenation is discussed.

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Section: Options For Treatmentmentioning

confidence: 99%

Atherosclerosis: Viewing the Problem from a Different Perspective Including Possible Treatment Options

Goldberg

2011

Lipid�Insights

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Elevation of spectral components of electrodermal activity precedes central nervous system oxygen toxicity symptoms in divers

Posada–Quintero,

Derrick,

Ellis

et al. 2024

Commun Med

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Correcting for tissue nitrogen excretion in multiple breath washout measurements

et al. 2017

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Nitrogen excreted from body tissues impacts the calculation of multiple breath nitrogen washout (MBWN2) outcomes. The aim of this study was to determine the effect of tissue N2 on MBWN2 outcomes in both healthy subjects and patients with CF and to assess whether it is possible to correct for tissue N2. The contribution of tissue N2 to MBWN2 outcomes was estimated by comparing MBWN2-derived functional residual capacity (FRCN2) to FRC measured by body plethysmography (FRCpleth) and by comparing MBW outcome measures derived from MBWN2 and sulfur hexafluoride MBW (MBWSF6). Compared to plethysmography and MBWSF6, MBWN2 overestimated FRC and lung clearance index (LCI). Application of mathematical tissue N2 corrections reduced FRCN2 values closer to FRCpleth in health and reduced LCIN2 in both health and CF, but did not explain all of the differences observed between N2-dependent and -independent techniques. Use of earlier washout cut-offs could reduce the influence of tissue N2. Applying tissue N2 corrections to LCIN2 measurements did not significantly affect the interpretation of treatment effects reported in a previously published interventional trial. While tissue N2 excretion likely has an impact on MBWN2 outcomes, better understanding of the nature of this phenomenon is required before routine correction can be implemented into current MBWN2 protocols.

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A Closed-Circuit Rebreather for the Characterization of Denitrogenation

Abstract: From a preliminary analysis, the proposed denitrogenation procedure proved to be adequate compared to other methods. An investigation of the method demonstrated that the system accuracy can be improved. A validation phase using more subjects may support the use of this new technology.

Cited by 3 publications

References 5 publications

Atherosclerosis: Viewing the Problem from a Different Perspective Including Possible Treatment Options

Atherosclerosis: Viewing the Problem from a Different Perspective Including Possible Treatment Options

Elevation of spectral components of electrodermal activity precedes central nervous system oxygen toxicity symptoms in divers

Correcting for tissue nitrogen excretion in multiple breath washout measurements

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