A Closed Xenon Anesthesia Delivery System

Dingley, John; Findlay, George; Foëx, Bernard A; Mecklenburgh, J. S.; Esmail, M.; Little, R. A.

doi:10.1097/00000542-200101000-00034

Cited by 21 publications

(16 citation statements)

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“…Currently, Xe is prepared on an industrial scale as a byproduct of liquid oxygen and nitrogen production by fractional distillation of liquefied air. Increased Xe gas production, coupled with improved Xe-recovery methods such as the Felix Dual™ closed-circuit respirator (Air Liquide Medical Systems, France), have the potential to lower the price of Xe enough to make it marketable as a clinical anesthetic (Dingley et al, 2001; Sanders, 2003; Stoppe et al, 2013). …”

Section: Introductionmentioning

confidence: 99%

Xenon–Protein Interactions: Characterization by X-Ray Crystallography and Hyper-CEST NMR

Roose

Zemerov

Dmochowski

2018

Methods in Enzymology

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The physiological activity of xenon has long been recognized, though the exact nature of its interactions with biomolecules remains poorly understood. Xe is an inert noble gas, but can act as a general anesthetic, most likely by binding internal hydrophobic cavities within proteins. Understanding Xe-protein interactions, therefore, can provide crucial insight regarding the mechanism of Xe anesthesia and potentially other general anesthetic agents. Historically, Xe-protein interactions have been studied primarily through X-ray crystallography and nuclear magnetic resonance (NMR). In this chapter, we first describe our methods for preparing Xe derivatives of protein crystals and identifying Xe-binding sites. Second, we detail our procedure for Xe hyper-CEST NMR spectroscopy, a versatile NMR technique well suited for characterizing the weak, transient nature of Xe-protein interactions.

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Section: Introductionmentioning

confidence: 99%

Xenon–Protein Interactions: Characterization by X-Ray Crystallography and Hyper-CEST NMR

Roose

Zemerov

Dmochowski

2018

Methods in Enzymology

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“…Em modelo animal, utilizando sistema fechado automatizado, demonstrou-se que o volume de xenônio utilizado para a realização de duas horas de anestesia foi de 7,9 litros; enquanto que para quatro horas de administração o volume consumido foi de 13,11 litros. Mais da metade do xenônio utilizado em duas horas de administração foi gasto nos primeiros trinta minutos 42 . A quantidade de xenônio necessária para encher o circuito de anestesia depende do volume do circuito e do modo de enchimento 21 .…”

Section: Náuseas E Vômitosunclassified

“…In an animal model using automated closed system, it was shown that the volume of xenon used for 2 hours of anesthesia was 7.9 liters, while for 4 hours the volume was 13.11 liters. More than half the xenon used in 2 hours of administration was used during the first 30 minutes 42 . Xenon amount needed to fill the anesthetic circuit depends on circuit volume and filling mode 21 .…”

Section: Consumption and Costsmentioning

confidence: 99%

Xenônio: farmacologia e uso clínico

Mendes¹,

Gomes²

2003

Rev. Bras. Anestesiol.

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“…Relevant methods of gas analysis that have been used experimentally include mass spectroscopy [21], laser refractometry [22], X‐ray absorption [23], gas chromatography [24], thermal conductivity [25] and ultrasound [26]. Mass spectrometry is perhaps the gold standard but is too expensive and bulky for clinical use.…”

mentioning

confidence: 99%

“…In this study we sought to compare the thermal conductivity and ultrasonic methods as these are likely to be the best contenders for this role. Both the machines investigated have been developed for previous clinical studies [7, 10, 26].…”

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confidence: 99%

Xenon measurement in breathing systems: a comparison of ultrasonic and thermal conductivity methods

et al. 2005

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SummaryXenon is an anaesthetic and possibly neuroprotective gas that is impossible to measure using conventional anaesthetic gas analysers. We compared the performance of two commissioned xenon analysers using ultrasonic and thermal conductivity principles against a reference method of laser refractometry. An experimental gas circuit was constructed and xenon concentrations compared over a range of 0-100% in oxygen. Eighty-two paired measurements were made comparing the experimental methods with laser refractometry. The ultrasonic method displayed good agreement with laser refractometry, with a mean difference of ) 0.74% and two standard deviation limits of agreement of + 1.08% to ) 2.56%. The agreement between laser refractometry and thermal conductivity was poor, the mean difference being ) 5.37%, with two standard deviation limits of agreement of + 0.6% to ) 11.3%. The ultrasonic method for measuring xenon concentrations can be used in breathing circuits. The thermal conductivity instrument may need further development.

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A Closed Xenon Anesthesia Delivery System

Cited by 21 publications

References 0 publications

Xenon–Protein Interactions: Characterization by X-Ray Crystallography and Hyper-CEST NMR

Xenon–Protein Interactions: Characterization by X-Ray Crystallography and Hyper-CEST NMR

Xenônio: farmacologia e uso clínico

Xenon measurement in breathing systems: a comparison of ultrasonic and thermal conductivity methods

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